2023
Proteomic Assessment of Hypoxia-pre-conditioned Human Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Demonstrates Promise in the Treatment of Cardiovascular Disease.
Xu CM, Karbasiafshar C, Teixeira RB, Ahsan N, Corssac GB, Sellke FW, Abid MR. Int. J. Mol. Sci. 2023, 24, 1674. https://doi.org/10.3390/ijms24021674
Reduction in mitochondrial ROS improves oxidative phosphorylation and provides resilience to coronary endothelium in non-reperfused myocardial infarction
Teixeira RB, Pfeiffer M, Zhang P, Shafique E, Rayta B, Karbasiafshar C, Ahsan N, Sellke FW, Abid MR. Basic Res Cardiol. 2023 Jan 13; volume 118, Article number: 3 (2023). doi: 10.1007/s00395-022-00976-x
Canagliflozin Improves Myocardial Perfusion, Fibrosis, and Function in a Swine Model of Chronic Myocardial Ischemia
Sabe, S. A., Xu, C. M., Sabra, M., Harris, D. D., Malhotra, A., Aboulgheit, A., Stanley, M., Abid, M. R., Sellke, F. W. Journal of the American Heart Association. 2023 Jan 3;12(1):e028623. doi: 10.1161/JAHA.122.028623.
2022
Extracellular vesicles modulate inflammatory signaling in chronically ischemic myocardium of swine with metabolic syndrome
Sabe SA, Scrimgeour LA, Karbasiafshar C, Sabra M, Xu CM, Aboulgheit A, Abid MR, Sellke FW. J Thorac Cardiovasc Surg. 2022 Aug 4; S0022-5223(22)00803-0. doi: 10.1016/j.jtcvs.2022.07.016.
Mechanisms and Clinical Implications of Endothelium-dependent Vasomotor Dysfunction in Coronary Microvasculature.
Sabe SA, Feng J, Sellke FW, Abid MR. Am J Physiol Heart Circ Physiol. 2022 Mar 25. doi: 10.1152/ajpheart.00603.2021.
Assessments of Microvascular Function in Organ Systems.
Xu C, Sellke FW, Abid MR. Am J Physiol Heart Circ Physiol. 2022 Mar 25. doi: 10.1152/ajpheart.00589.2021.
Braga KMS, Araujo EG, Sellke FW, Abid MR. Antioxidants (Basel). 2022 Feb 28;11(3):474. doi: 10.3390/antiox11030474
2021
Extracellular vesicles improve diastolic function and substructure in normal and high-fat diet models of chronic myocardial ischemia.
Aboulgheit A, Karbasiafshar C, Sabra M, Zhang Z, Sodha N, Abid MR, Sellke FW.J Thorac Cardiovasc Surg. 2021 Oct 13:S0022-5223(21)01420-3. doi: 10.1016/j.jtcvs.2021.07.062.
Lactobacillus plantarum probiotic induces Nrf2-mediated antioxidant signaling and eNOS expression resulting in improvement of myocardial diastolic function.
Aboulgheit A, Karbasiafshar C, Zhang Z, Sabra M, Shi G, Tucker A, Sodha N, Abid MR, Sellke FW. Am J Physiol Heart Circ Physiol. 2021 Nov 1;321(5):H839-H849. doi: 10.1152/ajpheart.00278.2021.
Optimization of mito-roGFP protocol to measure mitochondrial oxidative status in human coronary artery endothelial cells.
Teixeira RB, Karbasiafshar C, Sabra M, Abid MR. STAR Protocols, 2021 Sep 17; 2 (3), 100753, ISSN 2666-1667, https://doi.org/10.1016/j.xpro.2021.100753.
Clinical Application of Novel Therapies for Coronary Angiogenesis: Overview, Challenges, and Prospects.
Sabra M, Karbasiafshar C, Aboulgheit A, Raj S, Abid MR, Sellke FW. Int J Mol Sci. 2021 Apr 2;22(7):3722.
Mesenchymal stem cell-derived extracellular vesicles in the failing heart: past, present, and future.
Karbasiafshar C, Sellke FW, Abid MR. Am J Physiol Heart Circ Physiol. 2021 May 1;320(5):H1999-H2010.
Mass spectrometry-based proteomic platforms for better understanding of SARS-CoV-2 induced pathogenesis and potential diagnostic approaches.
Ahsan N, Rao RSP, Wilson RS, Punyamurtula U, Salvato F, Petersen M, Ahmed MK, Abid MR, Verburgt JC, Kihara D, Yang Z, Fornelli L, Foster SB, Ramratnam B. Proteomics. 2021 May;21(10):e2000279.
Drug repositioning candidates identified using in-silico quasi-quantum molecular simulation demonstrate reduced COVID-19 mortality in 1.5M patient records.
Alamgir J, Yajima M, Ergas R, Chen X, Hill N, Munir N, Saeed M, Gersing K, Haendel M, Chute CG, Abid MR. medRxiv. 2021 Apr 6:2021.03.22.21254110. doi: 10.1101/2021.03.22.21254110. Preprint.
Effects of High Fat Versus Normal Diet on Extracellular Vesicle-Induced Angiogenesis in a Swine Model of Chronic Myocardial Ischemia.
Aboulgheit A, Potz BA, Scrimgeour LA, Karbasiafshar C, Shi G, Zhang Z, Machan JT, Schorl C, Brodsky AS, Braga K, Pfeiffer M, Gao M, Cummings O, Sodha NR, Abid MR, Sellke FW. J Am Heart Assoc. 2021 Feb 16;10(4):e017437.
2020
The Relationship Between Reactive Oxygen Species and Endothelial Cell Metabolism.
Alhayaza R, Haque E, Karbasiafshar C, Sellke FW, Abid MR. Front Chem. 2020 Nov 26;8:592688.
Delivery of a mitochondria-targeted antioxidant from biocompatible, polymeric nanofibrous scaffolds.
Hamedani Y, Teixeira RB, Karbasiafshar C, Wipf P, Bhowmick S, Abid MR. FEBS Open Bio. 2020 Nov 11;11(1):35–47.
Intravenous injection of extracellular vesicles to treat chronic myocardial ischemia.
. PLoS One. 2020 Sep 11;15(9):e0238879.
Calpain inhibition decreases myocardial fibrosis in chronically ischemic hypercholesterolemic swine.
Brittany A Potz, Ashraf A. Sabe, Sharif A. Sabe, Isabella J. Lawandy, M. Ruhul Abid, Richard T. Clements, Frank W. Sellke. The Journal of Thoracic and Cardiovascular Surgery, 2020, In press.
2019
Oxidant-Dependent and Oxidant-Independent Proangiogenic and Vasomotor Signaling in Coronary Vascular Endothelium.
Aldosari S., Awad M., Gao M.Z., McCormack I.G., Sellke F.W., Abid M.R. In: Chakraborti S., Dhalla N., Dikshit M., Ganguly N. (eds) Modulation of Oxidative Stress in Heart Disease. Springer, Singapore.
Extracellular Vesicles Promote Arteriogenesis in Chronically Ischemic Myocardium in the Setting of Metabolic Syndrome.
Scrimgeour LA, Potz BA, Aboul Gheit A, Shi G, Stanley M, Zhang Z, Sodha NR, Ahsan N, Abid MR, Sellke FW.
J Am Heart Assoc. 2019 Aug 6;8(15):e012617.
A disease burden analysis of garment factory workers in Bangladesh: proposal for annual health screening.
Solinap G, Wawrzynski J, Chowdhury N, Zaman H, Abid T, Hoque TA, Afrooz S, Hamid I, Tanjin R, Tabassum CT, Paramita P, Duda RB, Abid MR.
Int Health. 2019 Jan 1;11(1):42-51.
2018
Genetic Alterations in Oxidant and Anti-Oxidant Enzymes in the Vascular System.
Awad MA, Aldosari SR, Abid MR.
Front Cardiovasc Med. 2018 Aug 9;5:107.
Extracellular Vesicle Injection Improves Myocardial Function and Increases Angiogenesis in a Swine Model of Chronic Ischemia.
Potz BA, Scrimgeour LA, Pavlov VI, Sodha NR, Abid MR, Sellke FW.
J Am Heart Assoc. 2018 Jun 12;7(12).
Subcellular Reactive Oxygen Species (ROS) in Cardiovascular Pathophysiology.
Aldosari S, Awad M, Harrington EO, Sellke FW, Abid MR.
Antioxidants (Basel). 2018 Jan 16;7(1).
2017
Continuous Glucose Monitoring in the Cardiac ICU: Current Use and Future Directions.
Scrimgeour LA, Potz BA, Sellke FW, Abid MR.
Clin Med Res (N Y). 2017 Nov;6(6):173-176. Epub 2017 Nov 24.
Murine Left Anterior Descending (LAD) Coronary Artery Ligation: An Improved and Simplified Model for Myocardial Infarction.
Reichert K, Colantuono B, McCormack I, Rodrigues F, Pavlov V, Abid MR.
J Vis Exp. 2017 Apr 2;(122).
Mitochondrial redox plays a critical role in the paradoxical effects of NAPDH oxidase-derived ROS on coronary endothelium.
Shafique E, Torina A, Reichert K, Colantuono B, Nur N, Zeeshan K, Ravichandran V, Liu Y, Feng J, Zeeshan K, Benjamin LE, Irani K, Harrington EO, Sellke FW, Abid MR.
Cardiovasc Res. 2017 Feb;113(2):234-246.
Calpain inhibition modulates glycogen synthase kinase 3β pathways in ischemic myocardium: A proteomic and mechanistic analysis.
Potz BA, Sabe AA, Elmadhun NY, Clements RT, Abid MR, Sodha NR, Sellke FW.
J Thorac Cardiovasc Surg. 2017 Feb;153(2):342-357.
2016
Role of Calpain in Pathogenesis of Human Disease Processes.
Potz BA, Abid MR, Sellke FW.
J Nat Sci. 2016;2(9).
Endothelial ROS and Impaired Myocardial Oxygen Consumption in Sepsis-induced Cardiac Dysfunction.
Potz BA, Sellke FW, Abid MR.
J Intensive Crit Care. 2016;2(1).
Calpains and Coronary Vascular Disease.
Potz BA, Sabe AA, Abid MR, Sellke FW.
Circ J. 2016;80(1):4-10.
Calpain inhibition improves collateral-dependent perfusion in a hypercholesterolemic swine model of chronic myocardial ischemia.
Sabe AA, Potz BA, Elmadhun NY, Liu Y, Feng J, Abid MR, Abbott JD, Senger DR, Sellke FW.
J Thorac Cardiovasc Surg. 2016 Jan;151(1):245-52.
2015
Antioxidant Therapy: Is it your Gateway to Improved Cardiovascular Health?
Abid MR, Sellke FW.
Pharm Anal Acta. 2015 Jan;6(1).
Calpain inhibition decreases myocardial apoptosis in a swine model of chronic myocardial ischemia.
Potz BA, Sabe AA, Elmadhun NY, Feng J, Liu Y, Mitchell H, Quesenberry P, Abid MR, Sellke FW.
Surgery. 2015 Aug;158(2):445-52.
2014
FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis.
Dharaneeswaran H, Abid MR, Yuan L, Dupuis D, Beeler D, Spokes KC, Janes L, Sciuto T, Kang PM, Jaminet SS, Dvorak A, Grant MA, Regan ER, Aird WC.
Circ Res. 2014 Jul 7;115(2):238-251.
2013
Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK.
Shafique E, Choy WC, Liu Y, Feng J, Cordeiro B, Lyra A, Arafah M, Yassin-Kassab A, Zanetti AV, Clements RT, Bianchi C, Benjamin LE, Sellke FW, Abid MR.
Aging (Albany NY). 2013 Jul;5(7):515-30.
2012
VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd.
Sun Z, Li X, Massena S, Kutschera S, Padhan N, Gualandi L, Sundvold-Gjerstad V, Gustafsson K, Choy WW, Zang G, Quach M, Jansson L, Phillipson M, Abid MR, Spurkland A, Claesson-Welsh L.
J Exp Med. 2012 Jul 2;209(7):1363-77.
2011
Direct sensing of endothelial oxidants by vascular endothelial growth factor receptor-2 and c-Src.
Lee M, Choy WC, Abid MR.
PLoS One. 2011;6(12):e28454.
2010
Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species.
Feng J, Damrauer SM, Lee M, Sellke FW, Ferran C, Abid MR.
Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1703-10.
Intracellular Ca2+ can compensate for the lack of NADPH oxidase-derived ROS in endothelial cells.
Lee M, Spokes KC, Aird WC, Abid MR.
FEBS Lett. 2010 Jul 16;584(14):3131-6.
2008
Hepatocyte growth factor inhibits VEGF-forkhead-dependent gene expression in endothelial cells.
Abid MR, Nadeau RJ, Spokes KC, Minami T, Li D, Shih SC, Aird WC.
Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):2042-8.
GAS6-induced signaling in human endothelial cells is mediated by FOXO1a.
Ganopolsky JG, Abid MR, Aird WC, Blostein MD.
J Thromb Haemost. 2008 Oct;6(10):1804-11.
Thrombin downregulates thrombomodulin expression and activity in primary human endothelial cells.
Séguin C, Abid MR, Spokes KC, Aird WC.
Endothelium. 2008 May-Jun;15(3):143-8.
Priming effect of homocysteine on inducible vascular cell adhesion molecule-1 expression in endothelial cells.
Séguin C, Abid MR, Spokes KC, Schoots IG, Brkovic A, Sirois MG, Aird WC.
Biomed Pharmacother. 2008 Jul-Aug;62(6):395-400.
2007
NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways.
Abid MR, Spokes KC, Shih SC, Aird WC.
J Biol Chem. 2007 Nov 30;282(48):35373-85.
G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence.
Hawkins BJ, Solt LA, Chowdhury I, Kazi AS, Abid MR, Aird WC, May MJ, Foskett JK, Madesh M.
Mol Cell Biol. 2007 Nov;27(21):7582-93.
2006
A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression.
Abid MR, Shih SC, Otu HH, Spokes KC, Okada Y, Curiel DT, Minami T, Aird WC.
J Biol Chem. 2006 Nov 17;281(46):35544-53.
Vascular endocan is preferentially expressed in tumor endothelium.
Abid MR, Yi X, Yano K, Shih SC, Aird WC.
Microvasc Res. 2006 Nov;72(3):136-45.
2005
Preconditioning of primary human endothelial cells with inflammatory mediators alters the “set point” of the cell.
Wada Y, Otu H, Wu S, Abid MR, Okada H, Libermann T, Kodama T, Shih SC, Minami T, Aird WC.
FASEB J. 2005 Nov;19(13):1914-6.
Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia.
Abid MR, Yano K, Guo S, Patel VI, Shrikhande G, Spokes KC, Ferran C, Aird WC.
J Biol Chem. 2005 Aug 19;280(33):29864-73.
Oxidant stress in renal pathophysiology.
Abid MR, Razzaque MS, Taguchi T.
Contrib Nephrol. 2005;148:135-53. Review.
Cisplatin-associated nephrotoxicity and pathological events.
Taguchi T, Nazneen A, Abid MR, Razzaque MS.
Contrib Nephrol. 2005;148:107-21. Review.