The research in our laboratory is directed at understanding the molecular mechanisms controlling the development and activation of both NK cells and non-classical T cells. More specifically, we study the contribution of innate-like cells during the immune response to cancer as well as infections, including murine cytomegalovirus (MCMV). Currently we are focusing on 3 main research thematic areas:

1. Immune responses to viruses – Understanding the innate immune response to cytomegalovirus (CMV). In this project we use animal models to understand the protective role of Natural Killer (NK) cells and non-classical T cells during murine CMV infection
2. Cancer Immunotherapy – We recently identified potential new checkpoint inhibitor targets. We used animal models and genetically modified mice as well as murine tumor models to examine these candidates.
3. NK cells and ILC development – using animal models and genetics, we define the development and differentiation of these important innate subsets.