| gnomAD | gnomAD is a resource that aggregates and harmonizes exome and genome sequencing data from a wide variety of large-scale sequencing projects. It provides data on millions of variants found in tens of thousands of individuals, offering insights into human genetic diversity. |
| cBioPortal | The cBioPortal for Cancer Genomics is an open-access resource that provides interactive visualization and analysis tools for exploring large-scale cancer genomics data sets. It compiles data from various cancer studies, including mutation, copy number alterations, mRNA and miRNA expression, and more. The portal is designed to assist researchers in understanding the genetic basis of cancer, identifying potential therapeutic targets, and exploring the relationship between genomic alterations and clinical outcomes. |
| COSMIC | The Catalogue of Somatic Mutations in Cancer (COSMIC) is a comprehensive database that catalogs information on somatic mutations in the context of cancer. It compiles data from scientific literature and large-scale sequencing projects, detailing point mutations, gene fusions, copy number changes, and more. COSMIC is an essential resource for researchers seeking to understand the mutational landscape of various cancers, identify recurrent genetic alterations across tumor types, and study the impact of these alterations on cancer |
| ClinVar | ClinVar is a freely accessible, public archive of reports of the relationships among human variations and phenotypes, with supporting evidence. It aggregates information about genomic variation and its impact on health, providing a resource for clinicians and researchers to assess how genetic variants relate to patient conditions. ClinVar includes submissions on genetic variants and their observed health effects, classifications of pathogenicity, and references to scientific publications, making it a vital tool for understanding genetic contributions to disease and for use in precision medicine. |
| Clinical Trials | ClinicalTrials.gov is a database of privately and publicly funded clinical studies conducted around the world. It provides information about the purpose, recruitment status, criteria for participation, and location of clinical trials, as well as results for completed studies. This resource is valuable for patients, healthcare providers, and researchers looking to find details on ongoing or past trials, understand the effectiveness of treatments, and learn about new interventions being tested for various health conditions and diseases. |
| GTEx Portal | The GTEx Portal is a public resource that provides data on gene expression and genetic variation from multiple human tissues. It is valuable for understanding the relationship between genotype and phenotype and for studying the genetic architecture of gene expression. |
| OncoKB | OncoKB is a precision oncology knowledge base that provides detailed information about the genetic alterations associated with cancer, their effects on protein function, and their clinical significance. It includes evidence-based therapeutic implications, such as FDA-approved treatments and investigational therapies linked to specific genetic mutations in cancer. OncoKB serves as a critical resource for oncologists, researchers, and clinical decision-makers, offering up-to-date information on actionable cancer mutations and guiding personalized cancer treatment and research strategies. |
| DepMap | The Dependency Map (DepMap) portal is a comprehensive resource aimed at illuminating the landscape of cancer vulnerabilities. It offers an extensive dataset that includes genetic dependency information, identifying genes and pathways critical for the survival of cancer cells. By integrating CRISPR-Cas9 gene knockout and RNAi data across numerous cancer cell lines, DepMap enables researchers to discover potential therapeutic targets by highlighting genes whose loss leads to cancer cell death. This resource supports the development of targeted cancer therapies by revealing specific dependencies that cancer cells have compared to normal cells, facilitating the advancement of precision oncology. |
| HPA | The Human Protein Atlas (HPA) is a comprehensive database that provides detailed information on the location, expression, and function of human proteins in various tissues and organs. Launched in 2003, it integrates antibody-based imaging, proteomics, transcriptomics, and bioinformatics to map the human proteome. The HPA is an open-access resource beneficial for scientific research, medical diagnostics, and understanding human biology at the cellular level. |
| CellAge | The CellAge database is a curated resource focusing on cell senescence, the irreversible halt in cell division linked to aging and disease. It includes genes associated with senescence, identified through experiments on human cells, and a gene expression signature of senescence. CellAge supports research into the aging process and potential interventions by facilitating systems biology analysis of cellular senescence. |
| Repurposing Data Portal | he Drug Repurposing Hub is a curated and annotated collection of FDA-approved drugs, clinical trial drugs, and pre-clinical tool compounds with a companion information resource. Order library plates to screen yourself or collaborate with the Broad Institute’s Center for the Development of Therapeutics to see if an existing drug may work against your novel target, model system, or indication. |
| The Early Detection Research Network | National Cancer Institute, The Early Detection Research Network - Biomarker Database |