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Research in the Hoffman-Kim Lab focuses on the development and rigorous characterization of 3D neural microtissues and other novel biomimetic platforms. Our 3D neural microtissues contain multiple neural cell types, brain-like stiffness, in vivo-like cell density, capillary-like networks, and mature neuronal firing. We use our biomimetic platforms to mimic in vivo conditions in an in vitro environment, allowing us to explore the cellular mechanisms of important concepts such as axon guidance and endothelial cell proliferation.  

The 3D neural microtissue model of the central nervous system (CNS) enables us to study neurological injuries and screen potential therapeutics in a high throughput and cost effective manner. We are leveraging the tremendous potential of this platform to expand our understanding of neural tissue’s responses to mechanical forces, toxicants, drugs and diseases.

The Hoffman-Kim Lab maintains an active research program with multiple collaborations across Brown University. The laboratory group is well equipped and experienced to succeed in collaborative research, as we are passionate about the complex discussions and actions required to engage in interdisciplinary science.