Publications

2024

González-Cruz, R. D., Wan, Y., Burgess, A., Calvao, D., Renken, W., Vecchio, F., Franck, C., Kesari, H., Hoffman-Kim, D. (2024). Cortical spheroids show strain-dependent cell viability loss and neurite disruption following sustained compression injury. PloS one, 19(8), e0295086. doi: 10.1371/journal.pone.0295086.

Wan, Y., Gonzalez Cruz, R. D., Hoffman-Kim, D., & Kesari, H. (2024). A mechanics theory for the exploration of a high-throughput, sterile 3D in vitro traumatic brain injury model. Biomechanics and Modeling in Mechanobiology. 23. 1-18. doi: 10.1007/s10237-024-01832-8.

2023

McLaughlin, R.M., Top, I., Laguna, A., Hernandez, C., Katz, H., Livi, L. L., Kramer, L., Zambuto, S. G., & Hoffman-Kim, D. (2023). Cortical Spheroid Model for Studying the Effects of Ischemic Brain Injury. In vitro models 2, 25–41. doi: 10.1007/s44164-023-00046-z.

2021

Lizarraga S, Li M, Maguire A, van Dyck L, Wu Q, Ouyang Q, Kavanaugh B, Hoffman-Kim D., et al. (2021). Human Neurons from Christianson Syndrome IPSCs Reveal Mutation-Specific Responses to Rescue Strategies. Science Translational Medicine 13 (580). doi: 10.1126/scitranslmed.aaw0682.

Sevetson, J., Theyel, B., & Hoffman-Kim, D. (2021). Cortical spheroids display oscillatory network dynamics. Lab on a Chip. 21 (23). doi: 10.1039/D1LC00737H

2018

Evans, E. B., Brady, S. W., Tripathi, A., & Hoffman-Kim D. Biomater Res. Schwann cell durotaxis can be guided by physiologically relevant stiffness gradients. (2018). Biomater Res 22, 14. doi: 10.1186/s40824-018-0124-z.

Boutin, M. E., Kramer, L. L., Livi, L. L., Brown, T., Moore, C., & Hoffman-Kim, D. (2018). A three-dimensional neural spheroid model for capillary-like network formation. Journal of neuroscience methods, 299, 55–63. doi: 10.1016/j.jneumeth.2017.01.014.

2016

Sadick, J., Boutin, M., Hoffman-Kim, D., & Darling, E. M. Protein characterization of intracellular target-sorted, formalin-fixed cell subpopulations. Sci Rep, 6, 33999 (2016). doi: 10.1038/srep33999.

López-Fagundo, C., Livi, L. L., Ramchal, T., Darling, E. M., & Hoffman-Kim, D. (2016). A biomimetic synthetic feeder layer supports the proliferation and self-renewal of mouse embryonic stem cells. Acta biomaterialia, 39, 55–64. doi: 10.1016/j.actbio.2016.04.047.

2015

Dingle, Y. T., Boutin, M. E., Chirila, A. M., Livi, L. L., Labriola, N. R., Jakubek, L. M., Morgan, J. R., Darling, E. M., Kauer, J. A., & Hoffman-Kim, D. (2015). Three-Dimensional Neural Spheroid Culture: An In Vitro Model for Cortical Studies. Tissue engineering. Part C, Methods, 21(12), 1274–1283. doi: 10.1089/ten.TEC.2015.0135.

2014

Boutin, M. E., & Hoffman-Kim, D. (2015). Application and assessment of optical clearing methods for imaging of tissue-engineered neural stem cell spheres. Tissue engineering. Part C, Methods, 21(3), 292–302. doi: 10.1089/ten.TEC.2014.0296.

López-Fagundo, C., Bar-Kochba, E., Livi, L. L., Hoffman-Kim, D., & Franck, C. (2014). Three-dimensional traction forces of Schwann cells on compliant substrates. Journal of the Royal Society, Interface, 11(97), 20140247. doi: 10.1098/rsif.2014.0247.

Toyjanova, J., Bar-Kochba, E., López-Fagundo, C., Reichner, J., Hoffman-Kim, D., & Franck, C. (2014). High resolution, large deformation 3D traction force microscopy. PloS one, 9(4), e90976. doi: 10.1371/journal.pone.0090976.

2013

López-Fagundo, C., Mitchel, J. A., Ramchal, T. D., Dingle, Y. T., & Hoffman-Kim, D. (2013). Navigating neurites utilize cellular topography of Schwann cell somas and processes for optimal guidance. Acta biomaterialia, 9(7), 7158–7168. doi: 10.1016/j.actbio.2013.03.032.

Mitchel, J. A., Martin, I. S., & Hoffman-Kim, D. (2013). Neurient: an algorithm for automatic tracing of confluent neuronal images to determine alignment. Journal of neuroscience methods, 214(2), 210–222. doi: 10.1016/j.jneumeth.2013.01.023.

2011

Mitchel, J. A., & Hoffman-Kim, D. (2011). Cellular scale anisotropic topography guides Schwann cell motility. PloS one, 6(9), e24316. doi: 10.1371/journal.pone.0024316.

Kim, S. Y., Kim, K. M., Hoffman-Kim, D., Song, H. K., & Palmore, G. T. (2011). Quantitative control of neuron adhesion at a neural interface using a conducting polymer composite with low electrical impedance. ACS applied materials & interfaces, 3(1), 16–21. doi: 10.1021/am1008369. 

2010

Richardson, J., & Hoffman-Kim, D. (2010). The importance of defining ‘data’ in data management policies: Commentary on: “Issues in data management”. Science and engineering ethics, 16(4), 749–751. doi: 10.1007/s11948-010-9231-5.

Kofron, C. M., Liu, Y. T., López-Fagundo, C. Y., Mitchel, J. A., & Hoffman-Kim, D. (2010). Neurite outgrowth at the biomimetic interface. Annals of biomedical engineering, 38(6), 2210–2225. doi: 10.1007/s10439-010-0054-y.

Hoffman-Kim, D., Mitchel, J. A., & Bellamkonda, R. V. (2010). Topography, cell response, and nerve regeneration. Annual review of biomedical engineering, 12, 203–231. doi: 10.1146/annurev-bioeng-070909-105351.

2009

Kofron, C. M., & Hoffman-Kim, D. (2009). Optimization by Response Surface Methodology of Confluent and Aligned Cellular Monolayers for Nerve Guidance. Cellular and molecular bioengineering, 2(4), 554–572. doi: 10.1007/s12195-009-0087-1.

Kofron, C. M., Fong, V. J., & Hoffman-Kim, D. (2009). Neurite outgrowth at the interface of 2D and 3D growth environments. Journal of neural engineering, 6(1), 016002. doi: 10.1088/1741-2560/6/1/016002.

2008

Li, G. N., & Hoffman-Kim, D. (2008). Evaluation of neurite outgrowth anisotropy using a novel application of circular analysis. Journal of neuroscience methods, 174(2), 202–214. doi: 10.1016/j.jneumeth.2008.07.001.

Abe, T. K., Honda, T., Takei, K., Mikoshiba, K., Hoffman-Kim, D., Jay, D. G., & Kuwano, R. (2008). Dynactin is essential for growth cone advance. Biochemical and biophysical research communications, 372(3), 418–422. doi: 10.1016/j.bbrc.2008.05.008.

Li, G. N., & Hoffman-Kim, D. (2008). Tissue-engineered platforms of axon guidance. Tissue engineering. Part B, Reviews, 14(1), 33–51. doi: 10.1089/teb.2007.0181.

Li, G. N., Liu, J., & Hoffman-Kim, D. (2008). Multi-molecular gradients of permissive and inhibitory cues direct neurite outgrowth. Annals of biomedical engineering, 36(6), 889–904. doi: 10.1007/s10439-008-9486-z.

2007

Bruder, J. M., Lee, A. P., & Hoffman-Kim, D. (2007). Biomimetic materials replicating Schwann cell topography enhance neuronal adhesion and neurite alignment in vitro. Journal of biomaterials science. Polymer edition, 18(8), 967–982. doi: 10.1163/156856207781494412.

Hoffman-Kim, D., Diefenbach, T. J., Eustace, B. K., & Jay, D. G. (2007). Chromophore-assisted laser inactivation. Methods in cell biology, 82, 335–354. doi: 10.1016/S0091-679X(06)82011-X.

Li, G. N., Livi, L. L., Gourd, C. M., Deweerd, E. S., & Hoffman-Kim, D. (2007). Genomic and morphological changes of neuroblastoma cells in response to three-dimensional matrices. Tissue engineering, 13(5), 1035–1047. doi: 10.1089/ten.2006.0251.

2006

Bruder, J. M., Monu, N. C., Harrison, M. W., & Hoffman-Kim, D. (2006). Fabrication of polymeric replicas of cell surfaces with nanoscale resolution. Langmuir: the ACS journal of surfaces and colloids, 22(20), 8266–8270. doi: 10.1021/la0608563.

2005 

Goldner, J. S., Bruder, J. M., Li, G., Gazzola, D., & Hoffman-Kim, D. (2006). Neurite bridging across micropatterned grooves. Biomaterials, 27(3), 460–472. doi: 10.1016/j.biomaterials.2005.06.035. 

Hoffman-Kim, D., Maish, M. S., Krueger, P. M., Lukoff, H., Bert, A., Hong, T., & Hopkins, R. A. (2005). Comparison of three myofibroblast cell sources for the tissue engineering of cardiac valves. Tissue engineering, 11(1-2), 288–301. doi: 10.1089/ten.2005.11.288.

2003

Maish, M. S., Hoffman-Kim, D., Krueger, P. M., Souza, J. M., Harper, J. J., 3rd, & Hopkins, R. A. (2003). Tricuspid valve biopsy: a potential source of cardiac myofibroblast cells for tissue-engineered cardiac valves. The Journal of heart valve disease, 12(2), 264–269.

2002

Hoffman-Kim, D., Kerner, J. A., Chen, A., Xu, A., Wang, T. F., & Jay, D. G. (2002). pp60(c-src) is a negative regulator of laminin-1-mediated neurite outgrowth in chick sensory neurons. Molecular and cellular neurosciences, 21(1), 81–93. doi: 10.1006/mcne.2002.1157.