Selected publications

Lee lab members ; * Equal contributions ; ^# Corresponding author(s) 

Jaewon Song, Li Zhang, Seokoh Moon, Ariana Fang, Guoxun Wang, Newsha Gheshm, Skylar A. Loeb, Paul Cao, Joselynn R. Wallace, Mia Madel Alfajaro, Madison S. Strine, Wandy L. Beatty, Amanda M. Jamieson, Robert C. Orchard, Bridget A. Robinson, Timothy J. Nice, Craig B. Wilen, Anthony Orvedahl, Tiffany A. Reese, Sanghyun Lee^#. Norovirus co-opts NINJ1 for selective protein secretion. Sci Adv. 11, eadu7985 (2025)

Jaewon Song*, Ryan D. Chow*, Mario A. Peña-Hernández*, Li Zhang*, Skylar A. Loeb, Eui-Young So, Olin D. Liang, Ping Ren, Sidi Chen, Craig B. Wilen^#, Sanghyun Lee^#. LRRC15 inhibits SARS-CoV-2 cellular entry in trans. Plos Biol. 20(10): e3001805. (2022)

Madison S. Strine, Mia Madel Alfajaro, Vincent R. Graziano, Jaewon Song, Leon L. Hsieh, Ryan Hill, Jun Guo, Kelli L. VanDussen, Robert C. Orchard, Megan T. Baldridge, Sanghyun Lee^#, Craig B. Wilen^#. Tuft cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity. Cell Reports. 41, 111593. (2022) (# Co-corresponding author)

Sanghyun Lee^#, Norovirus cell tropism: The road to uncovering its secret hideout. Cell Host Microbe, 30(4), 454-457. (2022) (Review)

Jaewon Song, Ryan D Chow, Mario Pena-Hernandez, Li Zhang, Skylar A Loeb, Eui-Young So, Olin D Liang, Craig B Wilen, Sanghyun Lee^#. LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry in trans. BioRxiv. (2021)

Sanghyun Lee, Megan T. Baldridge. Crossing the T’s on Norovirus, Cell Mol Gastroenterol Hepatol. 2021. (Review)

Sanghyun Lee, Megan T. Baldridge. Viruses RIG up intestinal immunity, Nat. Immunol. 2019. (Review)

Sanghyun Lee^#, Hejun Liu, Craig B. Wilen, Zoi E. Sychev, Chandni Desai, Barry L. Hykes Jr, Robert C. Orchard, Broc T. McCune, Ki-Wook Kim, Timothy J. Nice, Scott A. Handley, Megan T. Baldridge, Gaya K. Amarasinghe, Herbert W. Virgin^#. A Secreted Viral Non-Structural Protein Determines Intestinal Norovirus pathogenesis.  Cell Host Microbe, 25(6), 845-857. (2019). (# Co-corresponding author)

• Selected as Featured Article in the June issue.

Harshad Ingle*, Sanghyun Lee*, Teresa Ai, Anthony Orvedahl, Rachel Rodgers, Guoyan Zhao, Meagan Sullender, Stefan T. Peterson, Marissa Locke, Ta-Chiang Liu, Christine C. Yokoyama, Bridgett Sharp, Stacey Schultz-Cherry, Jonathan J. Miner, Megan T. Baldridge. Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ. Nat Microbiol. 4(7),1120-1128 (2019). (* Co-first author)

Jaewon Song*, Sanghyun Lee*, Dong-Yeon Cho, Sungwon Lee, Hyewon Kim, Namhee Yu, Sanghyuk Lee, and Kwangseog Ahn. Human cytomegalovirus induces and exploits Roquin to counteract the IRF1-mediated antiviral state. PNAS. ePub 2019. (* Co-first author)

Sanghyun Lee, Craig B. Wilen, Anthony Orvedahl, Broc T. McCune, Ki-Wook Kim, Robert C. Orchard, Stefan T. Peterson, Timothy J. Nice, Megan T. Baldridge, Herbert W. Virgin. Norovirus Cell Tropism is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine. Cell Host Microbe. 22, 449–459. (2017)

• Selected as Featured Article, and Previewed in Cell Host Microbe. 22, 427-429.

Sanghyun Lee, Megan T. Baldridge. Interferon-Lambda: A Potent Regulator of Intestinal Viral Infections. Front. Immunol. 8:749. (2017) (Review)

Megan T. Baldridge*, Sanghyun Lee*, Judy J. Brown, Nicole McAllister, Kelly Urbanek, Terence S. Dermody, Timothy J. Nice, Herbert W. Virgin. Expression of Ifnlr1 on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus. J. Virol. vol. 91 no. 7 e02079-16 (2017). (* Co-first author)

Sanghyun Lee, Jaewon Song, Sungchul Kim, Jongkyu Kim, Yujin Hong, Youngkyun Kim, Donghyun Kim, Daehyun Baek and Kwangseog Ahn. Selective Degradation of host MicroRNAs by an Intergenic HCMV Non-Coding RNA Accelerates Virus Production. Cell Host Microbe, 13(6), 678-690. (2013).

• Recommended by Faculty of 1000

Youngkyun Kim*, Sanghyun Lee*, Sungchul Kim, Donghyun Kim, Jin-Hyun Ahn and Kwangseog Ahn. Human Cytomegalovirus Clinical Strain-Specific microRNA miR-UL148D Targets the Human Chemokine RANTES during Infection. PLoS Pathog, 8(3), 1-12. (2012). (* Co-first author)

Stefan T. Peterson, Elizabeth A. Kennedy, Pamela H. Brigleb, Gwen M. Taylor, Kelly Urbanek, Traci L. Bricker, Sanghyun Lee, Haina Shin, Terence S. Dermody, Adrianus C. M. Boon, Megan T. Baldridge. Disruption of type III interferon genes Ifnl2 and Ifnl3 recapitulates loss of the type III IFN receptor in the mucosal antiviral response. J Virol. 2019 Aug 28. pii: JVI.01073-19.

Anthony Orvedahl, Michael R. McAllaster, Amy Sansone, Bria F. Dunlap, Chandni Desai, Ya-Ting Wang, Dale R. Balce, Cliff J. Luke, Sanghyun Lee, Robert C. Orchard, Maxim N. Artyomov, Scott A. Handley, John G. Doench, Gary A. Silverman, and Herbert W. Virgin. Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock. PNAS. August 13, 2019 116 (33) 16497-16506;

Craig B. Wilen, Sanghyun Lee, Leon L. Hsieh, Robert C. Orchard, Chandni Desai, Barry L. Hykes Jr., Michael R. McAllaster, Dale R. Balce, Taylor Feehley, Jonathan R. Brestoff, Christina A. Hickey, Christine C. Yokoyama, Ya-Ting Wang, Donna A. MacDuff, Darren Kreamalmayer, Michael R. Howitt, Jessica A. Neil, Ken Cadwell, Paul M. Allen, Scott A. Handley, Menno van Lookeren Campagne, Megan T. Baldridge, Herbert W. Virgin. Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science. 13;360(6385):204-208 (2018)

Scott B. Biering, Jayoung Choi, Rachel A. Halstrom, Hailey M. Brown, Wandy L. Beatty, Sanghyun Lee, Broc T. McCune, Erin Dominici, Lelia E. Williams, Robert C. Orchard, Craig B. Wilen, Masahiro Yamamoto, Jörn Coers, Gregory A. Taylor, Seungmin Hwang. Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases.         Cell Host Microbe. 22(1), 74-85. (2017)

Robert C. Orchard, Craig B. Wilen, John G. Doench, Megan T. Baldridge, Broc T. McCune, Ying-Chiang J. Lee, Sanghyun Lee, Shondra M. Pruett-Miller, Christopher A. Nelson, Daved H. Fremont, Herbert W. Virgin. Discovery of a proteinaceous cellular receptor for a norovirus. Science. 353(6302):933-6. (2016).

Sungchul Kim, Sanghyun Lee, Jinwook Shin, Youngkyun Kim, Irini Evnouchidou, Donghyun Kim, Young-Kook Kim, Young-Eui Kim, Jin-Hyun Ahn, Stanley R Riddell, Efstratios Stratikos, V Narry Kim and Kwangseog Ahn. Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1. Nat Immunol. 12(10):984-91. (2011).