We are pursuing the following areas:

Examine the molecular mechanism by which the EMT equips metastatic competence to cancer cells

Understand how the EMT process equips cancer cells with stem cell properties and promotes plasticity

Develop methods and markers for early detection of cancer cells with EMT/CSC properties within the primary tumor and in circulating tumor cells

Characterize the interplay between tumor cells and immune cells in regulating tumor progression

Using single-cell transcriptomics, genomics, and epigenomic approaches, characterize the heterogeneity in EMT and identify novel therapeutic to treat metastasis and chemoresistance

Assembled and maintained by Nick Kuburich, Ph.D.