Endothelial Injury and Repair: CPVB COBRE administrative supplement. Neurovascular aging phenotypes of Alzheimer’s disease and Progeria: Focus on inflammation and blood brain barrier. (06/01/2019-05/31/2020)

  • The goal of this work is to determine the inflammatory mechanisms of Alzheimer’s neuronal risk and Progeria neuronal resilience for the development of therapeutics for Alzheimer’s.

Endothelial Injury and Repair: CPVB COBRE PILOT Right Ventricular Fibrosis from Pulmonary Arterial Hypertension is Dependent on Macrophage IL-1b signaling. (11/01/2018-11/30/2020)

  • The goal of this work is to generate preliminary data on the macrophage mediated inflammatory mechanisms in right ventricular fibrosis and right ventricular dysfunction, an unexplored avenue for the development of immunobased therapies for cardiovascular conditions.

Macrophages Under Pressure in Right Ventricular Dysfunction Associated with Pulmonary Arterial Hypertension (3/1/2019-2/1/2020)

  • The goal of this work is to characterize the macrophage phenotypes and their role in impaired angiogenesis associated with right ventricular dysfunction and pulmonary hypertension

Sleeping Beauty to the Rescue in Pulmonary Arterial Hypertension (Summer Team UTRA Project, 6/2019-8/2019)

  • The goal of this project is to use the Sleeping Beauty gene transfer system to overexpress macrophage mediated VEGFA production and to increase angiogenesis with the ultimate aim of improving capillarization the failing RV of Pulmonary Arterial Hypertension patients.

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