SOBOL LAB
Welcome to the Sobol Lab!
The core of our laboratory’s mission is to employ scientific exploration to achieve advancements in our understanding of how the human genome is maintained. To that end, we work to make advances in cancer biology and environmental carcinogenesis through discovery, and goal-oriented dedication while emphasizing teamwork, inclusion, diversity, and education.
Lab Publications
“Research in the Sobol lab focuses on the role of DNA repair genes and pathways, especially the base excision repair pathway, the regulation of PARP activation, the response to genotoxins, the response to replication stress, and the identification of novel targets to overcome PARP-inhibitor and PARG-inhibitor resistance.”
Members of the lab are developing biological assays to evaluate PARP-activation, genotoxic stress, and gene-environment interactions. The lab utilizes these tools mechanistically and translationally to determine how PARP-dependent DNA damage response pathways impact tumor cell survival, cellular toxicity, phenotypes from environmental genotoxins (pollutants, ocean toxins, etc.), cellular aging, and response to chemo- and immune checkpoint-based therapies. Further, the lab is employing these tools and state-of-the-art proteomics approaches to uncover novel targets for enhanced chemotherapy response. Finally, we are working to develop small molecule inhibitors of select DNA repair proteins that may be used to overcome chemotherapy treatment resistance.
SOBOL LAB
SOBOL LAB
Welcome to the Sobol Lab!
The core of our laboratory’s mission is to employ scientific exploration to achieve advancements in our understanding of how the human genome is maintained. To that end, we work to make advances in cancer biology and environmental carcinogenesis through discovery, and goal-oriented dedication while emphasizing teamwork, inclusion, diversity, and education.
Lab Publications
“Research in the Sobol lab focuses on the role of DNA repair genes and pathways, especially the base excision repair pathway, the regulation of PARP activation, the response to genotoxins, the response to replication stress, and the identification of novel targets to overcome PARP-inhibitor and PARG-inhibitor resistance.”
Members of the lab are developing biological assays to evaluate PARP-activation, genotoxic stress, and gene-environment interactions. The lab utilizes these tools mechanistically and translationally to determine how PARP-dependent DNA damage response pathways impact tumor cell survival, cellular toxicity, phenotypes from environmental genotoxins (pollutants, ocean toxins, etc.), cellular aging, and response to chemo- and immune checkpoint-based therapies. Further, the lab is employing these tools and state-of-the-art proteomics approaches to uncover novel targets for enhanced chemotherapy response. Finally, we are working to develop small molecule inhibitors of select DNA repair proteins that may be used to overcome chemotherapy treatment resistance.
THE SOBOL LAB
THE SOBOL LAB