PUBLICATIONS

IN THE SOBOL LAB

Explore our collection of 140+ influential publications that reflect our unwavering commitment to advancing knowledge and making a meaningful impact in the fight against cancer.

PUBLICATIONS

IN THE SOBOL LAB

Explore our collection of 140+ influential publications that reflect our unwavering commitment to advancing knowledge and making a meaningful impact in the fight against cancer.

View Publications in PubMed

1.	Editorial: DNA repair and nucleic acid therapeutics in cancer. Sobol RW. NAR Cancer. 2023 Aug 28;5(3):zcad044. doi: 10.1093/narcan/zcad044. eCollection 2023 Sep. PMID: 37645072 Free PMC article. No abstract available.
2.	A multi-scale map of protein assemblies in the DNA damage response. Kratz A, Kim M, Kelly MR, Zheng F, Koczor CA, Li J, Ono K, Qin Y, Churas C, Chen J, Pillich RT, Park J, Modak M, Collier R, Licon K, Pratt D, Sobol RW, Krogan NJ, Ideker T. Cell Syst. 2023 Jun 21;14(6):447-463.e8. doi: 10.1016/j.cels.2023.04.007. Epub 2023 May 22. PMID: 37220749
3.	Co-creation and engagement in a DNA integrity cohort study. Parker LL, Bonner CM, Sobol RW, Arrieta MI. J Clin Transl Sci. 2023 May 22;7(1):e122. doi: 10.1017/cts.2023.556. eCollection 2023. PMID: 37313377 Free PMC article.
4.	Targeting HSF1 for cancer treatment: mechanisms and inhibitor development. Chin Y, Gumilar KE, Li XG, Tjokroprawiro BA, Lu CH, Lu J, Zhou M, Sobol RW, Tan M. Theranostics. 2023 Apr 17;13(7):2281-2300. doi: 10.7150/thno.82431. eCollection 2023. PMID: 37153737 Free PMC article. Review.
5.	Polβ/XRCC1 heterodimerization dictates DNA damage recognition and basal Polβ protein levels without interfering with mouse viability or fertility. Koczor CA, Thompson MK, Sharma N, Prakash A, Sobol RW. DNA Repair (Amst). 2023 Mar;123:103452. doi: 10.1016/j.dnarep.2023.103452. Epub 2023 Jan 20. PMID: 36702010
6.	WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency. Sobol RW. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2219963120. doi: 10.1073/pnas.2219963120. Epub 2023 Jan 4. PMID: 36598947 Free PMC article. No abstract available.
7.	Quantitative Analysis of Nuclear Poly(ADP-Ribose) Dynamics in Response to Laser-Induced DNA Damage. Koczor CA, Saville KM, Al-Rahahleh RQ, Andrews JF, Li J, Sobol RW. Methods Mol Biol. 2023;2609:43-59. doi: 10.1007/978-1-0716-2891-1_3. PMID: 36515828
8.	Editorial: Mechanistic studies of genome integrity, environmental health, and cancer etiology. Yan S, Zhao J, Kemp M, Sobol RW. Front Cell Dev Biol. 2022 Sep 28;10:1026326. doi: 10.3389/fcell.2022.1026326. eCollection 2022. PMID: 36247007 Free PMC article. No abstract available.
9.	A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage. Li J, Beiser A, Dey NB, Takeda S, Saha LK, Hirota K, Parker LL, Carter M, Arrieta MI, Sobol RW. NAR Genom Bioinform. 2022 Sep 13;4(3):lqac065. doi: 10.1093/nargab/lqac065. eCollection 2022 Sep. PMID: 36110898 Free PMC article.
10.	Live Cell Detection of Poly(ADP-Ribose) for Use in Genetic and Genotoxic Compound Screens. Koczor CA, Haider AJ, Saville KM, Li J, Andrews JF, Beiser AV, Sobol RW. Cancers (Basel). 2022 Jul 28;14(15):3676. doi: 10.3390/cancers14153676. PMID: 35954352 Free PMC article.
11.	Overcoming Temozolomide Resistance in Glioblastoma via Enhanced NAD⁺ Bioavailability and Inhibition of Poly-ADP-Ribose Glycohydrolase. Li J, Koczor CA, Saville KM, Hayat F, Beiser A, McClellan S, Migaud ME, Sobol RW. Cancers (Basel). 2022 Jul 22;14(15):3572. doi: 10.3390/cancers14153572. PMID: 35892832 Free PMC article.
12.	Correction to: Thymine DNA glycosylase as a novel target for melanoma. Mancuso P, Tricarico R, Bhattacharjee V, Cosentino L, Kadariya Y, Jelinek J, Nicolas E, Einarson M, Beeharry N, Devarajan K, Katz RA, Dorjsuren DG, Sun H, Simeonov A, Giordano A, Testa JR, Davidson G, Davidson I, Larue L, Sobol RW, Yen TJ, Bellacosa A. Oncogene. 2022 Jun;41(23):3300-3301. doi: 10.1038/s41388-022-02335-5. PMID: 35505094 No abstract available.
13.	Double-strand breaks: When DNA repair events accidentally meet. Fujii S, Sobol RW, Fuchs RP. DNA Repair (Amst). 2022 Apr;112:103303. doi: 10.1016/j.dnarep.2022.103303. Epub 2022 Feb 19. PMID: 35219626 Free PMC article. Review.
14.	A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells. Li J, Garavaglia S, Ye Z, Moretti A, Belyaeva OV, Beiser A, Ibrahim M, Wilk A, McClellan S, Klyuyeva AV, Goggans KR, Kedishvili NY, Salter EA, Wierzbicki A, Migaud ME, Mullett SJ, Yates NA, Camacho CJ, Rizzi M, Sobol RW. Commun Biol. 2021 Dec 21;4(1):1420. doi: 10.1038/s42003-021-02949-7. PMID: 34934174 Free PMC article.
15.	NAD⁺ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells. Li J, M Saville K, Ibrahim M, Zeng X, McClellan S, Angajala A, Beiser A, Andrews JF, Sun M, Koczor CA, Clark J, Hayat F, Makarov MV, Wilk A, Yates NA, Migaud ME, Sobol RW. NAR Cancer. 2021 Nov 17;3(4):zcab044. doi: 10.1093/narcan/zcab044. eCollection 2021 Dec. PMID: 34806016 Free PMC article.
16.	Primary saturation of α, β-unsaturated carbonyl containing fatty acids does not abolish electrophilicity. Snyder NW, O’Brien J, Singh B, Buchan G, Arroyo AD, Liu X, Bostwick A, Varner EL, Angajala A, Sobol RW, Blair IA, Mesaros C, Wendell SG. Chem Biol Interact. 2021 Dec 1;350:109689. doi: 10.1016/j.cbi.2021.109689. Epub 2021 Oct 8. PMID: 34634267 Free PMC article.
17.	Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD⁺/SIRT6 axis. Koczor CA, Saville KM, Andrews JF, Clark J, Fang Q, Li J, Al-Rahahleh RQ, Ibrahim M, McClellan S, Makarov MV, Migaud ME, Sobol RW. Cell Rep. 2021 Nov 2;37(5):109917. doi: 10.1016/j.celrep.2021.109917. PMID: 34731617 Free PMC article.
18.	CometChip enables parallel analysis of multiple DNA repair activities. Ge J, Ngo LP, Kaushal S, Tay IJ, Thadhani E, Kay JE, Mazzucato P, Chow DN, Fessler JL, Weingeist DM, Sobol RW, Samson LD, Floyd SR, Engelward BP. DNA Repair (Amst). 2021 Oct;106:103176. doi: 10.1016/j.dnarep.2021.103176. Epub 2021 Jul 10. PMID: 34365116 Free PMC article.
19.	SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity. Kim JH, Jeong K, Li J, Murphy JM, Vukadin L, Stone JK, Richard A, Tran J, Gillespie GY, Flemington EK, Sobol RW, Lim SS, Ahn EE. Nat Commun. 2021 Sep 21;12(1):5551. doi: 10.1038/s41467-021-25892-x. PMID: 34548489 Free PMC article.
20.	Exploiting DNA Endonucleases to Advance Mechanisms of DNA Repair. Thompson MK, Sobol RW, Prakash A. Biology (Basel). 2021 Jun 14;10(6):530. doi: 10.3390/biology10060530. PMID: 34198612 Free PMC article. Review.
21.	Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O’Sullivan RJ. Nat Struct Mol Biol. 2020 Dec;27(12):1152-1164. doi: 10.1038/s41594-020-0512-7. Epub 2020 Oct 12. PMID: 33046907 Free PMC article.
22.	NAD⁺-mediated regulation of mammalian base excision repair. Saville KM, Clark J, Wilk A, Rogers GD, Andrews JF, Koczor CA, Sobol RW. DNA Repair (Amst). 2020 Sep;93:102930. doi: 10.1016/j.dnarep.2020.102930. PMID: 33087267 Free PMC article. Review.
23.	Extracellular NAD⁺ enhances PARP-dependent DNA repair capacity independently of CD73 activity. Wilk A, Hayat F, Cunningham R, Li J, Garavaglia S, Zamani L, Ferraris DM, Sykora P, Andrews J, Clark J, Davis A, Chaloin L, Rizzi M, Migaud M, Sobol RW. Sci Rep. 2020 Jan 20;10(1):651. doi: 10.1038/s41598-020-57506-9. PMID: 31959836 Free PMC article.
24.	Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1. Sannai M, Doneddu V, Giri V, Seeholzer S, Nicolas E, Yip SC, Bassi MR, Mancuso P, Cortellino S, Cigliano A, Lurie R, Ding H, Chernoff J, Sobol RW, Yen TJ, Bagella L, Bellacosa A. DNA Repair (Amst). 2019 Oct;82:102687. doi: 10.1016/j.dnarep.2019.102687. Epub 2019 Aug 8. PMID: 31476572 Free PMC article.
25.	Stability and sub-cellular localization of DNA polymerase β is regulated by interactions with NQO1 and XRCC1 in response to oxidative stress. Fang Q, Andrews J, Sharma N, Wilk A, Clark J, Slyskova J, Koczor CA, Lans H, Prakash A, Sobol RW. Nucleic Acids Res. 2019 Jul 9;47(12):6269-6286. doi: 10.1093/nar/gkz293. PMID: 31287140 Free PMC article.
26.	Mechanisms of MTH1 inhibition-induced DNA strand breaks: The slippery slope from the oxidized nucleotide pool to genotoxic damage. Rai P, Sobol RW. DNA Repair (Amst). 2019 May;77:18-26. doi: 10.1016/j.dnarep.2019.03.001. Epub 2019 Mar 2. PMID: 30852368 Free PMC article. Review.
27.	Thymine DNA glycosylase as a novel target for melanoma. Mancuso P, Tricarico R, Bhattacharjee V, Cosentino L, Kadariya Y, Jelinek J, Nicolas E, Einarson M, Beeharry N, Devarajan K, Katz RA, Dorjsuren DG, Sun H, Simeonov A, Giordano A, Testa JR, Davidson G, Davidson I, Larue L, Sobol RW, Yen TJ, Bellacosa A. Oncogene. 2019 May;38(19):3710-3728. doi: 10.1038/s41388-018-0640-2. Epub 2019 Jan 23. PMID: 30674989 Free PMC article.
28.	Immunoregulatory protein B7-H3 regulates cancer stem cell enrichment and drug resistance through MVP-mediated MEK activation. Liu Z, Zhang W, Phillips JB, Arora R, McClellan S, Li J, Kim JH, Sobol RW, Tan M. Oncogene. 2019 Jan;38(1):88-102. doi: 10.1038/s41388-018-0407-9. Epub 2018 Aug 6. PMID: 30082909 Free PMC article.
29.	DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity. Li J, Svilar D, McClellan S, Kim JH, Ahn EE, Vens C, Wilson DM 3rd, Sobol RW. Oncotarget. 2018 Aug 3;9(60):31719-31743. doi: 10.18632/oncotarget.25859. eCollection 2018 Aug 3. PMID: 30167090 Free PMC article.
30.	Camptothecin Efficacy to Poison Top1 Is Altered by Bisphenol A in Mouse Embryonic Fibroblasts. Sonavane M, Sykora P, Andrews JF, Sobol RW, Gassman NR. Chem Res Toxicol. 2018 Jun 18;31(6):510-519. doi: 10.1021/acs.chemrestox.8b00050. Epub 2018 Jun 5. PMID: 29799191 Free PMC article.
31.	Application of the CometChip platform to assess DNA damage in field-collected blood samples from turtles. Sykora P, Chiari Y, Heaton A, Moreno N, Glaberman S, Sobol RW. Environ Mol Mutagen. 2018 May;59(4):322-333. doi: 10.1002/em.22183. Epub 2018 Mar 14. PMID: 29536573 Free PMC article.
32.	Next generation high throughput DNA damage detection platform for genotoxic compound screening. Sykora P, Witt KL, Revanna P, Smith-Roe SL, Dismukes J, Lloyd DG, Engelward BP, Sobol RW. Sci Rep. 2018 Feb 9;8(1):2771. doi: 10.1038/s41598-018-20995-w. PMID: 29426857 Free PMC article.
33.	Crosstalk between mismatch repair and base excision repair in human gastric cancer. Simonelli V, Leuzzi G, Basile G, D’Errico M, Fortini P, Franchitto A, Viti V, Brown AR, Parlanti E, Pascucci B, Palli D, Giuliani A, Palombo F, Sobol RW, Dogliotti E. Oncotarget. 2016 Jun 20;8(49):84827-84840. doi: 10.18632/oncotarget.10185. eCollection 2017 Oct 17. PMID: 29156686 Free PMC article.
34.	Development of a Cell-Based Assay for Measuring Base Excision Repair Responses. Golato T, Brenerman B, McNeill DR, Li J, Sobol RW, Wilson DM 3rd. Sci Rep. 2017 Oct 11;7(1):13007. doi: 10.1038/s41598-017-12963-7. PMID: 29021553 Free PMC article.
35.	DNA Polymerase Beta Participates in Mitochondrial DNA Repair. Sykora P, Kanno S, Akbari M, Kulikowicz T, Baptiste BA, Leandro GS, Lu H, Tian J, May A, Becker KA, Croteau DL, Wilson DM 3rd, Sobol RW, Yasui A, Bohr VA. Mol Cell Biol. 2017 Jul 28;37(16):e00237-17. doi: 10.1128/MCB.00237-17. Print 2017 Aug 15. PMID: 28559431 Free PMC article.
36.	Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease. Nagel ZD, Engelward BP, Brenner DJ, Begley TJ, Sobol RW, Bielas JH, Stambrook PJ, Wei Q, Hu JJ, Terry MB, Dilworth C, McAllister KA, Reinlib L, Worth L, Shaughnessy DT. Mutat Res. 2017 Aug;800-802:14-28. doi: 10.1016/j.mrfmmm.2017.03.007. Epub 2017 Apr 6. PMID: 28458064 Free PMC article. Review.
37.	Constrained Inversion and Spectral Unmixing in Multispectral Optoacoustic Tomography. Ding L, Dean-Ben XL, Burton NC, Sobol RW, Ntziachristos V, Razansky D. IEEE Trans Med Imaging. 2017 Aug;36(8):1676-1685. doi: 10.1109/TMI.2017.2686006. Epub 2017 Mar 22. PMID: 28333622 Free PMC article.
38.	Differential role of base excision repair proteins in mediating cisplatin cytotoxicity. Sawant A, Floyd AM, Dangeti M, Lei W, Sobol RW, Patrick SM. DNA Repair (Amst). 2017 Mar;51:46-59. doi: 10.1016/j.dnarep.2017.01.002. Epub 2017 Jan 11. PMID: 28110804 Free PMC article.
39.	Regulation of DNA Alkylation Damage Repair: Lessons and Therapeutic Opportunities. Soll JM, Sobol RW, Mosammaparast N. Trends Biochem Sci. 2017 Mar;42(3):206-218. doi: 10.1016/j.tibs.2016.10.001. Epub 2016 Nov 2. PMID: 27816326 Free PMC article. Review.
40.	FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage. Bigarella CL, Li J, Rimmelé P, Liang R, Sobol RW, Ghaffari S. J Biol Chem. 2017 Feb 17;292(7):3005-3015. doi: 10.1074/jbc.M116.769455. Epub 2016 Dec 19. PMID: 27994057 Free PMC article.
41.	UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase. Braganza A, Li J, Zeng X, Yates NA, Dey NB, Andrews J, Clark J, Zamani L, Wang XH, St Croix C, O’Sullivan R, Garcia-Exposito L, Brodsky JL, Sobol RW. J Biol Chem. 2017 Feb 10;292(6):2470-2484. doi: 10.1074/jbc.M116.766824. Epub 2016 Dec 21. PMID: 28003368 Free PMC article.
42.	Oxidative guanine base damage regulates human telomerase activity. Fouquerel E, Lormand J, Bose A, Lee HT, Kim GS, Li J, Sobol RW, Freudenthal BD, Myong S, Opresko PL. Nat Struct Mol Biol. 2016 Dec;23(12):1092-1100. doi: 10.1038/nsmb.3319. Epub 2016 Nov 7. PMID: 27820808 Free PMC article.
43.	Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD⁺ and retinoic acid. Moretti A, Li J, Donini S, Sobol RW, Rizzi M, Garavaglia S. Sci Rep. 2016 Oct 19;6:35710. doi: 10.1038/srep35710. PMID: 27759097 Free PMC article.
44.	The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products. Godin SK, Zhang Z, Herken BW, Westmoreland JW, Lee AG, Mihalevic MJ, Yu Z, Sobol RW, Resnick MA, Bernstein KA. Nucleic Acids Res. 2016 Sep 30;44(17):8199-215. doi: 10.1093/nar/gkw535. Epub 2016 Jun 13. PMID: 27298254 Free PMC article.
45.	A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy. Srivas R, Shen JP, Yang CC, Sun SM, Li J, Gross AM, Jensen J, Licon K, Bojorquez-Gomez A, Klepper K, Huang J, Pekin D, Xu JL, Yeerna H, Sivaganesh V, Kollenstart L, van Attikum H, Aza-Blanc P, Sobol RW, Ideker T. Mol Cell. 2016 Aug 4;63(3):514-25. doi: 10.1016/j.molcel.2016.06.022. Epub 2016 Jul 21. PMID: 27453043 Free PMC article.
46.	Administration of polysaccharide from Panax notoginseng prolonged the survival of H22 tumor-bearing mice. Li H, Gu L, Zhong Y, Chen Y, Zhang L, Zhang AR, Sobol RW, Chen T, Li J. Onco Targets Ther. 2016 Jun 8;9:3433-41. doi: 10.2147/OTT.S79427. eCollection 2016. PMID: 27354815 Free PMC article.
47.	Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition. Shen JP, Srivas R, Gross A, Li J, Jaehnig EJ, Sun SM, Bojorquez-Gomez A, Licon K, Sivaganesh V, Xu JL, Klepper K, Yeerna H, Pekin D, Qiu CP, van Attikum H, Sobol RW, Ideker T. Oncotarget. 2015 Nov 3;6(34):35755-69. doi: 10.18632/oncotarget.5928. PMID: 26437225 Free PMC article.
48.	Role of mismatch repair proteins in the processing of cisplatin interstrand cross-links. Sawant A, Kothandapani A, Zhitkovich A, Sobol RW, Patrick SM. DNA Repair (Amst). 2015 Nov;35:126-36. doi: 10.1016/j.dnarep.2015.10.003. Epub 2015 Oct 23. PMID: 26519826 Free PMC article.
49.	Gene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells. Chandran UR, Luthra S, Santana-Santos L, Mao P, Kim SH, Minata M, Li J, Benos PV, DeWang M, Hu B, Cheng SY, Nakano I, Sobol RW. Genom Data. 2015 Sep 1;5:333-336. doi: 10.1016/j.gdata.2015.07.007. PMID: 26251826 Free PMC article.
50.	Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivo. Quiñones JL, Thapar U, Yu K, Fang Q, Sobol RW, Demple B. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8602-7. doi: 10.1073/pnas.1501101112. Epub 2015 Jun 29. PMID: 26124145 Free PMC article.
51.	Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis. Brown MF, Leibowitz BJ, Chen D, He K, Zou F, Sobol RW, Beer-Stolz D, Zhang L, Yu J. Cell Death Dis. 2015 Apr 23;6(4):e1729. doi: 10.1038/cddis.2015.104. PMID: 25906152 Free PMC article.
52.	15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids. Wendell SG, Golin-Bisello F, Wenzel S, Sobol RW, Holguin F, Freeman BA. J Biol Chem. 2015 Feb 27;290(9):5868-80. doi: 10.1074/jbc.M114.635151. Epub 2015 Jan 12. PMID: 25586183 Free PMC article.
53.	A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi-1. Wang J, Li J, Santana-Santos L, Shuda M, Sobol RW, Van Houten B, Qian W. Mol Oncol. 2015 Feb;9(2):488-502. doi: 10.1016/j.molonc.2014.10.002. Epub 2014 Oct 17. PMID: 25458053 Free PMC article.
54.	Mitochondria, energetics, epigenetics, and cellular responses to stress. Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. Environ Health Perspect. 2014 Dec;122(12):1271-8. doi: 10.1289/ehp.1408418. Epub 2014 Aug 15. PMID: 25127496 Free PMC article. Review.
55.	HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β. Fang Q, Inanc B, Schamus S, Wang XH, Wei L, Brown AR, Svilar D, Sugrue KF, Goellner EM, Zeng X, Yates NA, Lan L, Vens C, Sobol RW. Nat Commun. 2014 Nov 26;5:5513. doi: 10.1038/ncomms6513. PMID: 25423885 Free PMC article.
56.	Preface. NAD metabolism and signaling: Critical pathways in bacteria, yeast and mammals influencing genome stability, cell survival and disease. Sobol RW. DNA Repair (Amst). 2014 Nov;23:1-3. doi: 10.1016/j.dnarep.2014.10.007. Epub 2014 Nov 15. PMID: 25454703 No abstract available.
57.	ARTD1 (PARP1) activation and NAD(+) in DNA repair and cell death. Fouquerel E, Sobol RW. DNA Repair (Amst). 2014 Nov;23:27-32. doi: 10.1016/j.dnarep.2014.09.004. Epub 2014 Oct 3. PMID: 25283336 Free PMC article. Review.
58.	ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents. Agnihotri S, Burrell K, Buczkowicz P, Remke M, Golbourn B, Chornenkyy Y, Gajadhar A, Fernandez NA, Clarke ID, Barszczyk MS, Pajovic S, Ternamian C, Head R, Sabha N, Sobol RW, Taylor MD, Rutka JT, Jones C, Dirks PB, Zadeh G, Hawkins C. Cancer Discov. 2014 Oct;4(10):1198-213. doi: 10.1158/2159-8290.CD-14-0157. Epub 2014 Aug 6. PMID: 25100205 Free PMC article.
59.	ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion. Fouquerel E, Goellner EM, Yu Z, Gagné JP, Barbi de Moura M, Feinstein T, Wheeler D, Redpath P, Li J, Romero G, Migaud M, Van Houten B, Poirier GG, Sobol RW. Cell Rep. 2014 Sep 25;8(6):1819-1831. doi: 10.1016/j.celrep.2014.08.036. Epub 2014 Sep 15. PMID: 25220464 Free PMC article.
60.	Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference. Bennett GR, Peters R, Wang XH, Hanne J, Sobol RW, Bundschuh R, Fishel R, Yoder KE. PLoS One. 2014 Jul 22;9(7):e103164. doi: 10.1371/journal.pone.0103164. eCollection 2014. PMID: 25051054 Free PMC article.
61.	Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin. Lan L, Nakajima S, Wei L, Sun L, Hsieh CL, Sobol RW, Bruchez M, Van Houten B, Yasui A, Levine AS. Nucleic Acids Res. 2014 Feb;42(4):2330-45. doi: 10.1093/nar/gkt1233. Epub 2013 Nov 29. PMID: 24293652 Free PMC article.
62.	Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair. Choi YJ, Li H, Son MY, Wang XH, Fornsaglio JL, Sobol RW, Lee M, Vijg J, Imholz S, Dollé ME, van Steeg H, Reiling E, Hasty P. PLoS One. 2014 Jan 23;9(1):e86358. doi: 10.1371/journal.pone.0086358. eCollection 2014. PMID: 24466051 Free PMC article.
63.	Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity. Kothandapani A, Sawant A, Dangeti VS, Sobol RW, Patrick SM. Nucleic Acids Res. 2013 Aug;41(15):7332-43. doi: 10.1093/nar/gkt479. Epub 2013 Jun 12. PMID: 23761438 Free PMC article.
64.	Base excision repair facilitates a functional relationship between Guanine oxidation and histone demethylation. Li J, Braganza A, Sobol RW. Antioxid Redox Signal. 2013 Jun 20;18(18):2429-43. doi: 10.1089/ars.2012.5107. Epub 2013 Feb 28. PMID: 23311711 Free PMC article. Review.
65.	MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. Joshi K, Banasavadi-Siddegowda Y, Mo X, Kim SH, Mao P, Kig C, Nardini D, Sobol RW, Chow LM, Kornblum HI, Waclaw R, Beullens M, Nakano I. Stem Cells. 2013 Jun;31(6):1051-63. doi: 10.1002/stem.1358. PMID: 23404835 Free PMC article.
66.	Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3. Mao P, Joshi K, Li J, Kim SH, Li P, Santana-Santos L, Luthra S, Chandran UR, Benos PV, Smith L, Wang M, Hu B, Cheng SY, Sobol RW, Nakano I. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8644-9. doi: 10.1073/pnas.1221478110. Epub 2013 May 6. PMID: 23650391 Free PMC article. Clinical Trial.
67.	Mutation research/fundamental and molecular mechanisms of mutagenesis: special issue: DNA repair and genetic instability. Williams K, Sobol RW. Mutat Res. 2013 Mar-Apr;743-744:1-3. doi: 10.1016/j.mrfmmm.2013.04.009. PMID: 23688353 Free PMC article. No abstract available.
68.	SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress. Nagaria P, Svilar D, Brown AR, Wang XH, Sobol RW, Wyatt MD. Mutat Res. 2013 Mar-Apr;743-744:26-32. doi: 10.1016/j.mrfmmm.2012.12.001. Epub 2012 Dec 17. PMID: 23253900 Free PMC article.
69.	Synthesis and characterization of DNA minor groove binding alkylating agents. Iyer P, Srinivasan A, Singh SK, Mascara GP, Zayitova S, Sidone B, Fouquerel E, Svilar D, Sobol RW, Bobola MS, Silber JR, Gold B. Chem Res Toxicol. 2013 Jan 18;26(1):156-68. doi: 10.1021/tx300437x. Epub 2012 Dec 26. PMID: 23234400 Free PMC article.
70.	Alkylation sensitivity screens reveal a conserved cross-species functionome. Svilar D, Dyavaiah M, Brown AR, Tang JB, Li J, McDonald PR, Shun TY, Braganza A, Wang XH, Maniar S, St Croix CM, Lazo JS, Pollack IF, Begley TJ, Sobol RW. Mol Cancer Res. 2012 Dec;10(12):1580-96. doi: 10.1158/1541-7786.MCR-12-0168. Epub 2012 Oct 4. PMID: 23038810 Free PMC article.
71.	Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors. Srinivasan A, Wang L, Cline CJ, Xie Z, Sobol RW, Xie XQ, Gold B. Biochemistry. 2012 Aug 7;51(31):6246-59. doi: 10.1021/bi300490r. Epub 2012 Jul 24. PMID: 22788932 Free PMC article.
72.	Quantitative, real-time analysis of base excision repair activity in cell lysates utilizing lesion-specific molecular beacons. Svilar D, Vens C, Sobol RW. J Vis Exp. 2012 Aug 6;(66):e4168. doi: 10.3791/4168. PMID: 22895410 Free PMC article.
73.	For MutY, it’s all about the OG. Sobol RW. Chem Biol. 2012 Mar 23;19(3):313-4. doi: 10.1016/j.chembiol.2012.03.002. PMID: 22444586 Free PMC article.
74.	Transcriptional profiling reveals elevated Sox2 in DNA polymerase ß null mouse embryonic fibroblasts. Li J, Luthra S, Wang XH, Chandran UR, Sobol RW. Am J Cancer Res. 2012;2(6):699-713. doi: 10.1158/1538-7445.am2012-699. Epub 2012 Nov 20. PMID: 23226616 Free PMC article.
75.	Genome instability caused by a germline mutation in the human DNA repair gene POLB. Sobol RW. PLoS Genet. 2012;8(11):e1003086. doi: 10.1371/journal.pgen.1003086. Epub 2012 Nov 8. PMID: 23144636 Free PMC article. No abstract available.
76.	Targeting DNA polymerase ß for therapeutic intervention. Goellner EM, Svilar D, Almeida KH, Sobol RW. Curr Mol Pharmacol. 2012 Jan;5(1):68-87. PMID: 22122465 Free PMC article. Review.
77.	XRCC1 and base excision repair balance in response to nitric oxide. Mutamba JT, Svilar D, Prasongtanakij S, Wang XH, Lin YC, Dedon PC, Sobol RW, Engelward BP. DNA Repair (Amst). 2011 Dec 10;10(12):1282-93. doi: 10.1016/j.dnarep.2011.10.008. Epub 2011 Oct 29. PMID: 22041025 Free PMC article.
78.	Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. Svilar D, Goellner EM, Almeida KH, Sobol RW. Antioxid Redox Signal. 2011 Jun 15;14(12):2491-507. doi: 10.1089/ars.2010.3466. Epub 2010 Oct 28. PMID: 20649466 Free PMC article. Review.
79.	Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. Li H, Wang P, Sun Q, Ding WX, Yin XM, Sobol RW, Stolz DB, Yu J, Zhang L. Cancer Res. 2011 May 15;71(10):3625-34. doi: 10.1158/0008-5472.CAN-10-4475. Epub 2011 Mar 28. PMID: 21444671 Free PMC article.
80.	N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide. Tang JB, Svilar D, Trivedi RN, Wang XH, Goellner EM, Moore B, Hamilton RL, Banze LA, Brown AR, Sobol RW. Neuro Oncol. 2011 May;13(5):471-86. doi: 10.1093/neuonc/nor011. Epub 2011 Mar 3. PMID: 21377995 Free PMC article.
81.	Novel role of base excision repair in mediating cisplatin cytotoxicity. Kothandapani A, Dangeti VS, Brown AR, Banze LA, Wang XH, Sobol RW, Patrick SM. J Biol Chem. 2011 Apr 22;286(16):14564-74. doi: 10.1074/jbc.M111.225375. Epub 2011 Feb 28. PMID: 21357694 Free PMC article.
82.	MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck. Langevin SM, Stone RA, Bunker CH, Lyons-Weiler MA, LaFramboise WA, Kelly L, Seethala RR, Grandis JR, Sobol RW, Taioli E. Cancer. 2011 Apr 1;117(7):1454-62. doi: 10.1002/cncr.25689. Epub 2010 Nov 8. PMID: 21425146 Free PMC article.
83.	The base excision repair pathway is required for efficient lentivirus integration. Yoder KE, Espeseth A, Wang XH, Fang Q, Russo MT, Lloyd RS, Hazuda D, Sobol RW, Fishel R. PLoS One. 2011 Mar 23;6(3):e17862. doi: 10.1371/journal.pone.0017862. PMID: 21448280 Free PMC article.
84.	Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair. Goellner EM, Grimme B, Brown AR, Lin YC, Wang XH, Sugrue KF, Mitchell L, Trivedi RN, Tang JB, Sobol RW. Cancer Res. 2011 Mar 15;71(6):2308-17. doi: 10.1158/0008-5472.CAN-10-3213. PMID: 21406402 Free PMC article.
85.	A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples. Lisovich A, Chandran UR, Lyons-Weiler MA, LaFramboise WA, Brown AR, Jakacki RI, Pollack IF, Sobol RW. BMC Med Genomics. 2011 Jan 26;4:14. doi: 10.1186/1755-8794-4-14. PMID: 21269491 Free PMC article.
86.	IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children’s Oncology Group. Pollack IF, Hamilton RL, Sobol RW, Nikiforova MN, Lyons-Weiler MA, LaFramboise WA, Burger PC, Brat DJ, Rosenblum MK, Holmes EJ, Zhou T, Jakacki RI; Children’s Oncology Group. Childs Nerv Syst. 2011 Jan;27(1):87-94. doi: 10.1007/s00381-010-1264-1. Epub 2010 Aug 20. PMID: 20725730 Free PMC article.
87.	Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant gliomas: a report from the Children’s Oncology Group. Pollack IF, Hamilton RL, Sobol RW, Nikiforova MN, Nikiforov YE, Lyons-Weiler MA, LaFramboise WA, Burger PC, Brat DJ, Rosenblum MK, Gilles FH, Yates AJ, Zhou T, Cohen KJ, Finlay JL, Jakacki RI; Children’s Oncology Group. Pediatr Blood Cancer. 2010 Dec 1;55(6):1066-71. doi: 10.1002/pbc.22634. PMID: 20589656 Free PMC article.
88.	MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index. Langevin SM, Stone RA, Bunker CH, Grandis JR, Sobol RW, Taioli E. Carcinogenesis. 2010 May;31(5):864-70. doi: 10.1093/carcin/bgq051. Epub 2010 Mar 2. PMID: 20197299 Free PMC article.
89.	Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage. Jelezcova E, Trivedi RN, Wang XH, Tang JB, Brown AR, Goellner EM, Schamus S, Fornsaglio JL, Sobol RW. Mutat Res. 2010 Apr 1;686(1-2):57-67. doi: 10.1016/j.mrfmmm.2010.01.016. Epub 2010 Jan 22. PMID: 20096707 Free PMC article.
90.	DNA polymerase beta-dependent long patch base excision repair in living cells. Asagoshi K, Liu Y, Masaoka A, Lan L, Prasad R, Horton JK, Brown AR, Wang XH, Bdour HM, Sobol RW, Taylor JS, Yasui A, Wilson SH. DNA Repair (Amst). 2010 Feb 4;9(2):109-19. doi: 10.1016/j.dnarep.2009.11.002. Epub 2009 Dec 16. PMID: 20006562 Free PMC article.
91.	Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage. Tang JB, Goellner EM, Wang XH, Trivedi RN, St Croix CM, Jelezcova E, Svilar D, Brown AR, Sobol RW. Mol Cancer Res. 2010 Jan;8(1):67-79. doi: 10.1158/1541-7786.MCR-09-0411. Epub 2010 Jan 12. PMID: 20068071 Free PMC article.
92.	Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase. Jones LE Jr, Ying L, Hofseth AB, Jelezcova E, Sobol RW, Ambs S, Harris CC, Espey MG, Hofseth LJ, Wyatt MD. Carcinogenesis. 2009 Dec;30(12):2123-9. doi: 10.1093/carcin/bgp256. PMID: 19864471 Free PMC article.
93.	Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation. Taioli E, Ragin C, Wang XH, Chen J, Langevin SM, Brown AR, Gollin SM, Garte S, Sobol RW. BMC Cancer. 2009 Oct 6;9:354. doi: 10.1186/1471-2407-9-354. PMID: 19807915 Free PMC article.
94.	Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. Yoshizawa K, Jelezcova E, Brown AR, Foley JF, Nyska A, Cui X, Hofseth LJ, Maronpot RM, Wilson SH, Sepulveda AR, Sobol RW. PLoS One. 2009 Aug 5;4(8):e6493. doi: 10.1371/journal.pone.0006493. PMID: 19654874 Free PMC article.
95.	Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1. Ueda R, Kohanbash G, Sasaki K, Fujita M, Zhu X, Kastenhuber ER, McDonald HA, Potter DM, Hamilton RL, Lotze MT, Khan SA, Sobol RW, Okada H. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10746-51. doi: 10.1073/pnas.0811817106. Epub 2009 Jun 11. PMID: 19520829 Free PMC article.
96.	Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice. Allen D, Herbert DC, McMahan CA, Rotrekl V, Sobol RW, Wilson SH, Walter CA. Biol Reprod. 2008 Nov;79(5):824-31. doi: 10.1095/biolreprod.108.069104. Epub 2008 Jul 23. PMID: 18650495 Free PMC article.
97.	Human methyl purine DNA glycosylase and DNA polymerase beta expression collectively predict sensitivity to temozolomide. Trivedi RN, Wang XH, Jelezcova E, Goellner EM, Tang JB, Sobol RW. Mol Pharmacol. 2008 Aug;74(2):505-16. doi: 10.1124/mol.108.045112. Epub 2008 May 13. PMID: 18477668 Free PMC article.
98.	Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. Kronenberg G, Harms C, Sobol RW, Cardozo-Pelaez F, Linhart H, Winter B, Balkaya M, Gertz K, Gay SB, Cox D, Eckart S, Ahmadi M, Juckel G, Kempermann G, Hellweg R, Sohr R, Hörtnagl H, Wilson SH, Jaenisch R, Endres M. J Neurosci. 2008 Jul 9;28(28):7219-30. doi: 10.1523/JNEUROSCI.0940-08.2008. PMID: 18614692 Free PMC article.
99.	CHIPping away at base excision repair. Sobol RW. Mol Cell. 2008 Feb 29;29(4):413-5. doi: 10.1016/j.molcel.2008.02.004. PMID: 18313379
100.	A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification. Almeida KH, Sobol RW. DNA Repair (Amst). 2007 Jun 1;6(6):695-711. doi: 10.1016/j.dnarep.2007.01.009. Epub 2007 Mar 6. PMID: 17337257 Free PMC article. Review.
101.	Overexpression of Dicer in precursor lesions of lung adenocarcinoma. Chiosea S, Jelezcova E, Chandran U, Luo J, Mantha G, Sobol RW, Dacic S. Cancer Res. 2007 Mar 1;67(5):2345-50. doi: 10.1158/0008-5472.CAN-06-3533. PMID: 17332367
102.	DNA polymerase beta null mouse embryonic fibroblasts harbor a homozygous null mutation in DNA polymerase iota. Sobol RW. DNA Repair (Amst). 2007 Jan 4;6(1):3-7. doi: 10.1016/j.dnarep.2006.08.005. Epub 2006 Sep 18. PMID: 16979388 Free PMC article. No abstract available.
103.	Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma. Chiosea S, Jelezcova E, Chandran U, Acquafondata M, McHale T, Sobol RW, Dhir R. Am J Pathol. 2006 Nov;169(5):1812-20. doi: 10.2353/ajpath.2006.060480. PMID: 17071602 Free PMC article.
104.	O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort. Pollack IF, Hamilton RL, Sobol RW, Burnham J, Yates AJ, Holmes EJ, Zhou T, Finlay JL. J Clin Oncol. 2006 Jul 20;24(21):3431-7. doi: 10.1200/JCO.2006.05.7265. PMID: 16849758
105.	The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death. Trivedi RN, Almeida KH, Fornsaglio JL, Schamus S, Sobol RW. Cancer Res. 2005 Jul 15;65(14):6394-400. doi: 10.1158/0008-5472.CAN-05-0715. PMID: 16024643
106.	Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. Endres M, Biniszkiewicz D, Sobol RW, Harms C, Ahmadi M, Lipski A, Katchanov J, Mergenthaler P, Dirnagl U, Wilson SH, Meisel A, Jaenisch R. J Clin Invest. 2004 Jun;113(12):1711-21. doi: 10.1172/JCI20926. PMID: 15199406 Free PMC article.
107.	Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. Sobol RW, Kartalou M, Almeida KH, Joyce DF, Engelward BP, Horton JK, Prasad R, Samson LD, Wilson SH. J Biol Chem. 2003 Oct 10;278(41):39951-9. doi: 10.1074/jbc.M306592200. Epub 2003 Jul 25. PMID: 12882965
108.	Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens. Cabelof DC, Guo Z, Raffoul JJ, Sobol RW, Wilson SH, Richardson A, Heydari AR. Cancer Res. 2003 Sep 15;63(18):5799-807. PMID: 14522902
109.	Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice. Sobol RW, Foley JF, Nyska A, Davidson MG, Wilson SH. DNA Repair (Amst). 2003 May 13;2(5):609-22. doi: 10.1016/s1568-7864(03)00026-0. PMID: 12713817
110.	Binary system for selective photoaffinity labeling of base excision repair DNA polymerases. Lavrik OI, Kolpashchikov DM, Prasad R, Sobol RW, Wilson SH. Nucleic Acids Res. 2002 Jul 15;30(14):e73. doi: 10.1093/nar/gnf073. PMID: 12136121 Free PMC article.
111.	Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Sobol RW, Watson DE, Nakamura J, Yakes FM, Hou E, Horton JK, Ladapo J, Van Houten B, Swenberg JA, Tindall KR, Samson LD, Wilson SH. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6860-5. doi: 10.1073/pnas.092662499. Epub 2002 Apr 30. PMID: 11983862 Free PMC article.
112.	Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage. Horton JK, Baker A, Berg BJ, Sobol RW, Wilson SH. DNA Repair (Amst). 2002 Apr 29;1(4):317-33. doi: 10.1016/s1568-7864(02)00008-3. PMID: 12509250
113.	DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage. Tomicic MT, Thust R, Sobol RW, Kaina B. Cancer Res. 2001 Oct 15;61(20):7399-403. PMID: 11606369
114.	Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair. Lavrik OI, Prasad R, Sobol RW, Horton JK, Ackerman EJ, Wilson SH. J Biol Chem. 2001 Jul 6;276(27):25541-8. doi: 10.1074/jbc.M102125200. Epub 2001 May 4. PMID: 11340072
115.	The response of human breast tumour cell lines with altered polymerase beta levels to cisplatin and radiation. Raaphorst GP, Cybulski SE, Sobol R, Ng CE. Anticancer Res. 2001 May-Jun;21(3B):2079-83. PMID: 11497301
116.	Mammalian DNA beta-polymerase in base excision repair of alkylation damage. Sobol RW, Wilson SH. Prog Nucleic Acid Res Mol Biol. 2001;68:57-74. doi: 10.1016/s0079-6603(01)68090-5. PMID: 11554313 Review.
117.	The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity. Sobol RW, Prasad R, Evenski A, Baker A, Yang XP, Horton JK, Wilson SH. Nature. 2000 Jun 15;405(6788):807-10. doi: 10.1038/35015598. PMID: 10866204
118.	DNA polymerase beta and mammalian base excision repair. Wilson SH, Sobol RW, Beard WA, Horton JK, Prasad R, Vande Berg BJ. Cold Spring Harb Symp Quant Biol. 2000;65:143-55. doi: 10.1101/sqb.2000.65.143. PMID: 12760029 Review. No abstract available.
119.	Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage. Ochs K, Sobol RW, Wilson SH, Kaina B. Cancer Res. 1999 Apr 1;59(7):1544-51. PMID: 10197627
120.	Selective mRNA degradation by antisense oligonucleotide-2,5A chimeras: involvement of RNase H and RNase L. Robbins I, Mitta G, Vichier-Guerre S, Sobol R, Ubysz A, Rayner B, Lebleu B. Biochimie. 1998 Aug-Sep;80(8-9):711-20. doi: 10.1016/s0300-9084(99)80024-8. PMID: 9865493
121.	Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines. Chen KH, Yakes FM, Srivastava DK, Singhal RK, Sobol RW, Horton JK, Van Houten B, Wilson SH. Nucleic Acids Res. 1998 Apr 15;26(8):2001-7. doi: 10.1093/nar/26.8.2001. PMID: 9518496 Free PMC article.
122.	Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells. Fortini P, Pascucci B, Parlanti E, Sobol RW, Wilson SH, Dogliotti E. Biochemistry. 1998 Mar 17;37(11):3575-80. doi: 10.1021/bi972999h. PMID: 9530283
123.	Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA. Biade S, Sobol RW, Wilson SH, Matsumoto Y. J Biol Chem. 1998 Jan 9;273(2):898-902. doi: 10.1074/jbc.273.2.898. PMID: 9422747
124.	Requirement of mammalian DNA polymerase-beta in base-excision repair. Sobol RW, Horton JK, Kühn R, Gu H, Singhal RK, Prasad R, Rajewsky K, Wilson SH. Nature. 1996 Jan 11;379(6561):183-6. doi: 10.1038/379183a0. PMID: 8538772
125.	Inhibition of HIV-1 replication and activation of RNase L by phosphorothioate/phosphodiester 2′,5′-oligoadenylate derivatives. Sobol RW, Henderson EE, Kon N, Shao J, Hitzges P, Mordechai E, Reichenbach NL, Charubala R, Schirmeister H, Pfleiderer W, et al. J Biol Chem. 1995 Mar 17;270(11):5963-78. doi: 10.1074/jbc.270.11.5963. PMID: 7890727
126.	Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome. Suhadolnik RJ, Reichenbach NL, Hitzges P, Sobol RW, Peterson DL, Henry B, Ablashi DV, Müller WE, Schröder HC, Carter WA, et al. Clin Infect Dis. 1994 Jan;18 Suppl 1:S96-104. doi: 10.1093/clinids/18.supplement_1.s96. PMID: 8148461 Clinical Trial.
127.	HIV-1 reverse transcriptase: inhibition by 2′,5′-oligoadenylates. Sobol RW, Fisher WL, Reichenbach NL, Kumar A, Beard WA, Wilson SH, Charubala R, Pfleiderer W, Suhadolnik RJ. Biochemistry. 1993 Nov 16;32(45):12112-8. doi: 10.1021/bi00096a023. PMID: 7692966
128.	Mapping of nucleic acid binding in proteolytic domains of HIV-1 reverse transcriptase. Kumar A, Kim HR, Sobol RW, Becerra SP, Lee BJ, Hatfield DL, Suhadolnik RJ, Wilson SH. Biochemistry. 1993 Jul 27;32(29):7466-74. doi: 10.1021/bi00080a018. PMID: 7687875
129.	Chemical synthesis and biological characterization of phosphorothioate analogs of 2′, 5′-3′-deoxyadenylate trimer. Sobol RW, Charubala R, Pfleiderer W, Suhadolnik RJ. Nucleic Acids Res. 1993 May 25;21(10):2437-43. doi: 10.1093/nar/21.10.2437. PMID: 7685081 Free PMC article.
130.	Localization of a polynucleotide binding region in the HIV-1 reverse transcriptase: implications for primer binding. Sobol RW, Suhadolnik RJ, Kumar A, Lee BJ, Hatfield DL, Wilson SH. Biochemistry. 1991 Nov 5;30(44):10623-31. doi: 10.1021/bi00108a004. PMID: 1718424
131.	Heterogeneous nuclear RNA from hairy cell leukemia patients activates 2′,5′-oligoadenylate synthetase. Hubbell HR, Sheetz PC, Iogal SS, Brodsky I, Kariko K, Li SW, Suhadolnik RJ, Sobol RW. Anticancer Res. 1991 Sep-Oct;11(5):1927-32. PMID: 1768064
132.	Purine 8-substitution modulates the ribonuclease L binding and activation abilities of 2′,5′-oligoadenylates. Kanou M, Ohomori H, Nagai K, Yokoyama S, Suhadolnik RJ, Sobol R Jr, Takaku H. Biochem Biophys Res Commun. 1991 Apr 30;176(2):769-74. doi: 10.1016/s0006-291x(05)80251-7. PMID: 2025289
133.	Cordycepin analogues of 2′,5′-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase. Müller WE, Weiler BE, Charubala R, Pfleiderer W, Leserman L, Sobol RW, Suhadolnik RJ, Schröder HC. Biochemistry. 1991 Feb 26;30(8):2027-33. doi: 10.1021/bi00222a004. PMID: 1705437
134.	Chemical synthesis and biological activities of analogues of 2′,5′-oligoadenylates containing 8-substituted adenosine derivatives. Kanou M, Ohomori H, Takaku H, Yokoyama S, Kawai G, Suhadolnik RJ, Sobol R Jr. Nucleic Acids Res. 1990 Aug 11;18(15):4439-46. doi: 10.1093/nar/18.15.4439. PMID: 2167468 Free PMC article.
135.	2′,5′ A synthetase: allosteric activation by fructose 1,6-bisphosphate. Suhadolnik RJ, Li SW, Sobol RW, Varnum JM. Biochem Biophys Res Commun. 1990 Jun 29;169(3):1198-203. doi: 10.1016/0006-291x(90)92023-s. PMID: 2363721
136.	Phosphorothioate analogues of (2′-5′)(A)4: agonist and antagonist activities in intact cells. Charachon G, Sobol RW, Bisbal C, Salehzada T, Silhol M, Charubala R, Pfleiderer W, Lebleu B, Suhadolnik RJ. Biochemistry. 1990 Mar 13;29(10):2550-6. doi: 10.1021/bi00462a017. PMID: 2159324
137.	Phosphorothioate and cordycepin analogues of 2′,5′-oligoadenylate: inhibition of human immunodeficiency virus type 1 reverse transcriptase and infection in vitro. Montefiori DC, Sobol RW Jr, Li SW, Reichenbach NL, Suhadolnik RJ, Charubala R, Pfleiderer W, Modliszewski A, Robinson WE Jr, Mitchell WM. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7191-4. doi: 10.1073/pnas.86.18.7191. PMID: 2476814 Free PMC article.
138.	2- and 8-azido photoaffinity probes. 1. Enzymatic synthesis, characterization, and biological properties of 2- and 8-azido photoprobes of 2-5A and photolabeling of 2-5A binding proteins. Suhadolnik RJ, Karikó K, Sobol RW Jr, Li SW, Reichenbach NL, Haley BE. Biochemistry. 1988 Nov 29;27(24):8840-6. doi: 10.1021/bi00424a023. PMID: 3242613
139.	2- and 8-azido photoaffinity probes. 2. Studies on the binding process of 2-5A synthetase by photosensitive ATP analogues. Suhadolnik RJ, Li SW, Sobol RW Jr, Haley BE. Biochemistry. 1988 Nov 29;27(24):8846-51. doi: 10.1021/bi00424a024. PMID: 2853970
140.	Phosphorothioate analogues of 2′,5′-oligoadenylate. Activation of 2′,5′-oligoadenylate-dependent endoribonuclease by 2′,5′-phosphorothioate cores and 5′-monophosphates. Karikó K, Li SW, Sobol RW Jr, Suhadolnik RJ, Charubala R, Pfleiderer W. Biochemistry. 1987 Nov 3;26(22):7136-42. doi: 10.1021/bi00396a040. PMID: 3427063
141.	Phosphorothioate analogues of 2′,5′-oligoadenylate. Enzymatically synthesized 2′,5′-phosphorothioate dimer and trimer: unequivocal structural assignment and activation of 2′,5′-oligoadenylate-dependent endoribonuclease. Karikó K, Sobol RW Jr, Suhadolnik L, Li SW, Reichenbach NL, Suhadolnik RJ, Charubala R, Pfleiderer W. Biochemistry. 1987 Nov 3;26(22):7127-35. doi: 10.1021/bi00396a039. PMID: 3427062

View Publications in PubMed

1.	Editorial: DNA repair and nucleic acid therapeutics in cancer. Sobol RW. NAR Cancer. 2023 Aug 28;5(3):zcad044. doi: 10.1093/narcan/zcad044. eCollection 2023 Sep. PMID: 37645072 Free PMC article. No abstract available.
2.	A multi-scale map of protein assemblies in the DNA damage response. Kratz A, Kim M, Kelly MR, Zheng F, Koczor CA, Li J, Ono K, Qin Y, Churas C, Chen J, Pillich RT, Park J, Modak M, Collier R, Licon K, Pratt D, Sobol RW, Krogan NJ, Ideker T. Cell Syst. 2023 Jun 21;14(6):447-463.e8. doi: 10.1016/j.cels.2023.04.007. Epub 2023 May 22. PMID: 37220749
3.	Co-creation and engagement in a DNA integrity cohort study. Parker LL, Bonner CM, Sobol RW, Arrieta MI. J Clin Transl Sci. 2023 May 22;7(1):e122. doi: 10.1017/cts.2023.556. eCollection 2023. PMID: 37313377 Free PMC article.
4.	Targeting HSF1 for cancer treatment: mechanisms and inhibitor development. Chin Y, Gumilar KE, Li XG, Tjokroprawiro BA, Lu CH, Lu J, Zhou M, Sobol RW, Tan M. Theranostics. 2023 Apr 17;13(7):2281-2300. doi: 10.7150/thno.82431. eCollection 2023. PMID: 37153737 Free PMC article. Review.
5.	Polβ/XRCC1 heterodimerization dictates DNA damage recognition and basal Polβ protein levels without interfering with mouse viability or fertility. Koczor CA, Thompson MK, Sharma N, Prakash A, Sobol RW. DNA Repair (Amst). 2023 Mar;123:103452. doi: 10.1016/j.dnarep.2023.103452. Epub 2023 Jan 20. PMID: 36702010
6.	WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency. Sobol RW. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2219963120. doi: 10.1073/pnas.2219963120. Epub 2023 Jan 4. PMID: 36598947 Free PMC article. No abstract available.
7.	Quantitative Analysis of Nuclear Poly(ADP-Ribose) Dynamics in Response to Laser-Induced DNA Damage. Koczor CA, Saville KM, Al-Rahahleh RQ, Andrews JF, Li J, Sobol RW. Methods Mol Biol. 2023;2609:43-59. doi: 10.1007/978-1-0716-2891-1_3. PMID: 36515828
8.	Editorial: Mechanistic studies of genome integrity, environmental health, and cancer etiology. Yan S, Zhao J, Kemp M, Sobol RW. Front Cell Dev Biol. 2022 Sep 28;10:1026326. doi: 10.3389/fcell.2022.1026326. eCollection 2022. PMID: 36247007 Free PMC article. No abstract available.
9.	A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage. Li J, Beiser A, Dey NB, Takeda S, Saha LK, Hirota K, Parker LL, Carter M, Arrieta MI, Sobol RW. NAR Genom Bioinform. 2022 Sep 13;4(3):lqac065. doi: 10.1093/nargab/lqac065. eCollection 2022 Sep. PMID: 36110898 Free PMC article.
10.	Live Cell Detection of Poly(ADP-Ribose) for Use in Genetic and Genotoxic Compound Screens. Koczor CA, Haider AJ, Saville KM, Li J, Andrews JF, Beiser AV, Sobol RW. Cancers (Basel). 2022 Jul 28;14(15):3676. doi: 10.3390/cancers14153676. PMID: 35954352 Free PMC article.
11.	Overcoming Temozolomide Resistance in Glioblastoma via Enhanced NAD⁺ Bioavailability and Inhibition of Poly-ADP-Ribose Glycohydrolase. Li J, Koczor CA, Saville KM, Hayat F, Beiser A, McClellan S, Migaud ME, Sobol RW. Cancers (Basel). 2022 Jul 22;14(15):3572. doi: 10.3390/cancers14153572. PMID: 35892832 Free PMC article.
12.	Correction to: Thymine DNA glycosylase as a novel target for melanoma. Mancuso P, Tricarico R, Bhattacharjee V, Cosentino L, Kadariya Y, Jelinek J, Nicolas E, Einarson M, Beeharry N, Devarajan K, Katz RA, Dorjsuren DG, Sun H, Simeonov A, Giordano A, Testa JR, Davidson G, Davidson I, Larue L, Sobol RW, Yen TJ, Bellacosa A. Oncogene. 2022 Jun;41(23):3300-3301. doi: 10.1038/s41388-022-02335-5. PMID: 35505094 No abstract available.
13.	Double-strand breaks: When DNA repair events accidentally meet. Fujii S, Sobol RW, Fuchs RP. DNA Repair (Amst). 2022 Apr;112:103303. doi: 10.1016/j.dnarep.2022.103303. Epub 2022 Feb 19. PMID: 35219626 Free PMC article. Review.
14.	A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells. Li J, Garavaglia S, Ye Z, Moretti A, Belyaeva OV, Beiser A, Ibrahim M, Wilk A, McClellan S, Klyuyeva AV, Goggans KR, Kedishvili NY, Salter EA, Wierzbicki A, Migaud ME, Mullett SJ, Yates NA, Camacho CJ, Rizzi M, Sobol RW. Commun Biol. 2021 Dec 21;4(1):1420. doi: 10.1038/s42003-021-02949-7. PMID: 34934174 Free PMC article.
15.	NAD⁺ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells. Li J, M Saville K, Ibrahim M, Zeng X, McClellan S, Angajala A, Beiser A, Andrews JF, Sun M, Koczor CA, Clark J, Hayat F, Makarov MV, Wilk A, Yates NA, Migaud ME, Sobol RW. NAR Cancer. 2021 Nov 17;3(4):zcab044. doi: 10.1093/narcan/zcab044. eCollection 2021 Dec. PMID: 34806016 Free PMC article.
16.	Primary saturation of α, β-unsaturated carbonyl containing fatty acids does not abolish electrophilicity. Snyder NW, O’Brien J, Singh B, Buchan G, Arroyo AD, Liu X, Bostwick A, Varner EL, Angajala A, Sobol RW, Blair IA, Mesaros C, Wendell SG. Chem Biol Interact. 2021 Dec 1;350:109689. doi: 10.1016/j.cbi.2021.109689. Epub 2021 Oct 8. PMID: 34634267 Free PMC article.
17.	Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD⁺/SIRT6 axis. Koczor CA, Saville KM, Andrews JF, Clark J, Fang Q, Li J, Al-Rahahleh RQ, Ibrahim M, McClellan S, Makarov MV, Migaud ME, Sobol RW. Cell Rep. 2021 Nov 2;37(5):109917. doi: 10.1016/j.celrep.2021.109917. PMID: 34731617 Free PMC article.
18.	CometChip enables parallel analysis of multiple DNA repair activities. Ge J, Ngo LP, Kaushal S, Tay IJ, Thadhani E, Kay JE, Mazzucato P, Chow DN, Fessler JL, Weingeist DM, Sobol RW, Samson LD, Floyd SR, Engelward BP. DNA Repair (Amst). 2021 Oct;106:103176. doi: 10.1016/j.dnarep.2021.103176. Epub 2021 Jul 10. PMID: 34365116 Free PMC article.
19.	SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity. Kim JH, Jeong K, Li J, Murphy JM, Vukadin L, Stone JK, Richard A, Tran J, Gillespie GY, Flemington EK, Sobol RW, Lim SS, Ahn EE. Nat Commun. 2021 Sep 21;12(1):5551. doi: 10.1038/s41467-021-25892-x. PMID: 34548489 Free PMC article.
20.	Exploiting DNA Endonucleases to Advance Mechanisms of DNA Repair. Thompson MK, Sobol RW, Prakash A. Biology (Basel). 2021 Jun 14;10(6):530. doi: 10.3390/biology10060530. PMID: 34198612 Free PMC article. Review.
21.	Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O’Sullivan RJ. Nat Struct Mol Biol. 2020 Dec;27(12):1152-1164. doi: 10.1038/s41594-020-0512-7. Epub 2020 Oct 12. PMID: 33046907 Free PMC article.
22.	NAD⁺-mediated regulation of mammalian base excision repair. Saville KM, Clark J, Wilk A, Rogers GD, Andrews JF, Koczor CA, Sobol RW. DNA Repair (Amst). 2020 Sep;93:102930. doi: 10.1016/j.dnarep.2020.102930. PMID: 33087267 Free PMC article. Review.
23.	Extracellular NAD⁺ enhances PARP-dependent DNA repair capacity independently of CD73 activity. Wilk A, Hayat F, Cunningham R, Li J, Garavaglia S, Zamani L, Ferraris DM, Sykora P, Andrews J, Clark J, Davis A, Chaloin L, Rizzi M, Migaud M, Sobol RW. Sci Rep. 2020 Jan 20;10(1):651. doi: 10.1038/s41598-020-57506-9. PMID: 31959836 Free PMC article.
24.	Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1. Sannai M, Doneddu V, Giri V, Seeholzer S, Nicolas E, Yip SC, Bassi MR, Mancuso P, Cortellino S, Cigliano A, Lurie R, Ding H, Chernoff J, Sobol RW, Yen TJ, Bagella L, Bellacosa A. DNA Repair (Amst). 2019 Oct;82:102687. doi: 10.1016/j.dnarep.2019.102687. Epub 2019 Aug 8. PMID: 31476572 Free PMC article.
25.	Stability and sub-cellular localization of DNA polymerase β is regulated by interactions with NQO1 and XRCC1 in response to oxidative stress. Fang Q, Andrews J, Sharma N, Wilk A, Clark J, Slyskova J, Koczor CA, Lans H, Prakash A, Sobol RW. Nucleic Acids Res. 2019 Jul 9;47(12):6269-6286. doi: 10.1093/nar/gkz293. PMID: 31287140 Free PMC article.
26.	Mechanisms of MTH1 inhibition-induced DNA strand breaks: The slippery slope from the oxidized nucleotide pool to genotoxic damage. Rai P, Sobol RW. DNA Repair (Amst). 2019 May;77:18-26. doi: 10.1016/j.dnarep.2019.03.001. Epub 2019 Mar 2. PMID: 30852368 Free PMC article. Review.
27.	Thymine DNA glycosylase as a novel target for melanoma. Mancuso P, Tricarico R, Bhattacharjee V, Cosentino L, Kadariya Y, Jelinek J, Nicolas E, Einarson M, Beeharry N, Devarajan K, Katz RA, Dorjsuren DG, Sun H, Simeonov A, Giordano A, Testa JR, Davidson G, Davidson I, Larue L, Sobol RW, Yen TJ, Bellacosa A. Oncogene. 2019 May;38(19):3710-3728. doi: 10.1038/s41388-018-0640-2. Epub 2019 Jan 23. PMID: 30674989 Free PMC article.
28.	Immunoregulatory protein B7-H3 regulates cancer stem cell enrichment and drug resistance through MVP-mediated MEK activation. Liu Z, Zhang W, Phillips JB, Arora R, McClellan S, Li J, Kim JH, Sobol RW, Tan M. Oncogene. 2019 Jan;38(1):88-102. doi: 10.1038/s41388-018-0407-9. Epub 2018 Aug 6. PMID: 30082909 Free PMC article.
29.	DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity. Li J, Svilar D, McClellan S, Kim JH, Ahn EE, Vens C, Wilson DM 3rd, Sobol RW. Oncotarget. 2018 Aug 3;9(60):31719-31743. doi: 10.18632/oncotarget.25859. eCollection 2018 Aug 3. PMID: 30167090 Free PMC article.
30.	Camptothecin Efficacy to Poison Top1 Is Altered by Bisphenol A in Mouse Embryonic Fibroblasts. Sonavane M, Sykora P, Andrews JF, Sobol RW, Gassman NR. Chem Res Toxicol. 2018 Jun 18;31(6):510-519. doi: 10.1021/acs.chemrestox.8b00050. Epub 2018 Jun 5. PMID: 29799191 Free PMC article.
31.	Application of the CometChip platform to assess DNA damage in field-collected blood samples from turtles. Sykora P, Chiari Y, Heaton A, Moreno N, Glaberman S, Sobol RW. Environ Mol Mutagen. 2018 May;59(4):322-333. doi: 10.1002/em.22183. Epub 2018 Mar 14. PMID: 29536573 Free PMC article.
32.	Next generation high throughput DNA damage detection platform for genotoxic compound screening. Sykora P, Witt KL, Revanna P, Smith-Roe SL, Dismukes J, Lloyd DG, Engelward BP, Sobol RW. Sci Rep. 2018 Feb 9;8(1):2771. doi: 10.1038/s41598-018-20995-w. PMID: 29426857 Free PMC article.
33.	Crosstalk between mismatch repair and base excision repair in human gastric cancer. Simonelli V, Leuzzi G, Basile G, D’Errico M, Fortini P, Franchitto A, Viti V, Brown AR, Parlanti E, Pascucci B, Palli D, Giuliani A, Palombo F, Sobol RW, Dogliotti E. Oncotarget. 2016 Jun 20;8(49):84827-84840. doi: 10.18632/oncotarget.10185. eCollection 2017 Oct 17. PMID: 29156686 Free PMC article.
34.	Development of a Cell-Based Assay for Measuring Base Excision Repair Responses. Golato T, Brenerman B, McNeill DR, Li J, Sobol RW, Wilson DM 3rd. Sci Rep. 2017 Oct 11;7(1):13007. doi: 10.1038/s41598-017-12963-7. PMID: 29021553 Free PMC article.
35.	DNA Polymerase Beta Participates in Mitochondrial DNA Repair. Sykora P, Kanno S, Akbari M, Kulikowicz T, Baptiste BA, Leandro GS, Lu H, Tian J, May A, Becker KA, Croteau DL, Wilson DM 3rd, Sobol RW, Yasui A, Bohr VA. Mol Cell Biol. 2017 Jul 28;37(16):e00237-17. doi: 10.1128/MCB.00237-17. Print 2017 Aug 15. PMID: 28559431 Free PMC article.
36.	Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease. Nagel ZD, Engelward BP, Brenner DJ, Begley TJ, Sobol RW, Bielas JH, Stambrook PJ, Wei Q, Hu JJ, Terry MB, Dilworth C, McAllister KA, Reinlib L, Worth L, Shaughnessy DT. Mutat Res. 2017 Aug;800-802:14-28. doi: 10.1016/j.mrfmmm.2017.03.007. Epub 2017 Apr 6. PMID: 28458064 Free PMC article. Review.
37.	Constrained Inversion and Spectral Unmixing in Multispectral Optoacoustic Tomography. Ding L, Dean-Ben XL, Burton NC, Sobol RW, Ntziachristos V, Razansky D. IEEE Trans Med Imaging. 2017 Aug;36(8):1676-1685. doi: 10.1109/TMI.2017.2686006. Epub 2017 Mar 22. PMID: 28333622 Free PMC article.
38.	Differential role of base excision repair proteins in mediating cisplatin cytotoxicity. Sawant A, Floyd AM, Dangeti M, Lei W, Sobol RW, Patrick SM. DNA Repair (Amst). 2017 Mar;51:46-59. doi: 10.1016/j.dnarep.2017.01.002. Epub 2017 Jan 11. PMID: 28110804 Free PMC article.
39.	Regulation of DNA Alkylation Damage Repair: Lessons and Therapeutic Opportunities. Soll JM, Sobol RW, Mosammaparast N. Trends Biochem Sci. 2017 Mar;42(3):206-218. doi: 10.1016/j.tibs.2016.10.001. Epub 2016 Nov 2. PMID: 27816326 Free PMC article. Review.
40.	FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage. Bigarella CL, Li J, Rimmelé P, Liang R, Sobol RW, Ghaffari S. J Biol Chem. 2017 Feb 17;292(7):3005-3015. doi: 10.1074/jbc.M116.769455. Epub 2016 Dec 19. PMID: 27994057 Free PMC article.
41.	UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase. Braganza A, Li J, Zeng X, Yates NA, Dey NB, Andrews J, Clark J, Zamani L, Wang XH, St Croix C, O’Sullivan R, Garcia-Exposito L, Brodsky JL, Sobol RW. J Biol Chem. 2017 Feb 10;292(6):2470-2484. doi: 10.1074/jbc.M116.766824. Epub 2016 Dec 21. PMID: 28003368 Free PMC article.
42.	Oxidative guanine base damage regulates human telomerase activity. Fouquerel E, Lormand J, Bose A, Lee HT, Kim GS, Li J, Sobol RW, Freudenthal BD, Myong S, Opresko PL. Nat Struct Mol Biol. 2016 Dec;23(12):1092-1100. doi: 10.1038/nsmb.3319. Epub 2016 Nov 7. PMID: 27820808 Free PMC article.
43.	Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD⁺ and retinoic acid. Moretti A, Li J, Donini S, Sobol RW, Rizzi M, Garavaglia S. Sci Rep. 2016 Oct 19;6:35710. doi: 10.1038/srep35710. PMID: 27759097 Free PMC article.
44.	The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products. Godin SK, Zhang Z, Herken BW, Westmoreland JW, Lee AG, Mihalevic MJ, Yu Z, Sobol RW, Resnick MA, Bernstein KA. Nucleic Acids Res. 2016 Sep 30;44(17):8199-215. doi: 10.1093/nar/gkw535. Epub 2016 Jun 13. PMID: 27298254 Free PMC article.
45.	A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy. Srivas R, Shen JP, Yang CC, Sun SM, Li J, Gross AM, Jensen J, Licon K, Bojorquez-Gomez A, Klepper K, Huang J, Pekin D, Xu JL, Yeerna H, Sivaganesh V, Kollenstart L, van Attikum H, Aza-Blanc P, Sobol RW, Ideker T. Mol Cell. 2016 Aug 4;63(3):514-25. doi: 10.1016/j.molcel.2016.06.022. Epub 2016 Jul 21. PMID: 27453043 Free PMC article.
46.	Administration of polysaccharide from Panax notoginseng prolonged the survival of H22 tumor-bearing mice. Li H, Gu L, Zhong Y, Chen Y, Zhang L, Zhang AR, Sobol RW, Chen T, Li J. Onco Targets Ther. 2016 Jun 8;9:3433-41. doi: 10.2147/OTT.S79427. eCollection 2016. PMID: 27354815 Free PMC article.
47.	Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition. Shen JP, Srivas R, Gross A, Li J, Jaehnig EJ, Sun SM, Bojorquez-Gomez A, Licon K, Sivaganesh V, Xu JL, Klepper K, Yeerna H, Pekin D, Qiu CP, van Attikum H, Sobol RW, Ideker T. Oncotarget. 2015 Nov 3;6(34):35755-69. doi: 10.18632/oncotarget.5928. PMID: 26437225 Free PMC article.
48.	Role of mismatch repair proteins in the processing of cisplatin interstrand cross-links. Sawant A, Kothandapani A, Zhitkovich A, Sobol RW, Patrick SM. DNA Repair (Amst). 2015 Nov;35:126-36. doi: 10.1016/j.dnarep.2015.10.003. Epub 2015 Oct 23. PMID: 26519826 Free PMC article.
49.	Gene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells. Chandran UR, Luthra S, Santana-Santos L, Mao P, Kim SH, Minata M, Li J, Benos PV, DeWang M, Hu B, Cheng SY, Nakano I, Sobol RW. Genom Data. 2015 Sep 1;5:333-336. doi: 10.1016/j.gdata.2015.07.007. PMID: 26251826 Free PMC article.
50.	Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivo. Quiñones JL, Thapar U, Yu K, Fang Q, Sobol RW, Demple B. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8602-7. doi: 10.1073/pnas.1501101112. Epub 2015 Jun 29. PMID: 26124145 Free PMC article.
51.	Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis. Brown MF, Leibowitz BJ, Chen D, He K, Zou F, Sobol RW, Beer-Stolz D, Zhang L, Yu J. Cell Death Dis. 2015 Apr 23;6(4):e1729. doi: 10.1038/cddis.2015.104. PMID: 25906152 Free PMC article.
52.	15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids. Wendell SG, Golin-Bisello F, Wenzel S, Sobol RW, Holguin F, Freeman BA. J Biol Chem. 2015 Feb 27;290(9):5868-80. doi: 10.1074/jbc.M114.635151. Epub 2015 Jan 12. PMID: 25586183 Free PMC article.
53.	A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi-1. Wang J, Li J, Santana-Santos L, Shuda M, Sobol RW, Van Houten B, Qian W. Mol Oncol. 2015 Feb;9(2):488-502. doi: 10.1016/j.molonc.2014.10.002. Epub 2014 Oct 17. PMID: 25458053 Free PMC article.
54.	Mitochondria, energetics, epigenetics, and cellular responses to stress. Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. Environ Health Perspect. 2014 Dec;122(12):1271-8. doi: 10.1289/ehp.1408418. Epub 2014 Aug 15. PMID: 25127496 Free PMC article. Review.
55.	HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β. Fang Q, Inanc B, Schamus S, Wang XH, Wei L, Brown AR, Svilar D, Sugrue KF, Goellner EM, Zeng X, Yates NA, Lan L, Vens C, Sobol RW. Nat Commun. 2014 Nov 26;5:5513. doi: 10.1038/ncomms6513. PMID: 25423885 Free PMC article.
56.	Preface. NAD metabolism and signaling: Critical pathways in bacteria, yeast and mammals influencing genome stability, cell survival and disease. Sobol RW. DNA Repair (Amst). 2014 Nov;23:1-3. doi: 10.1016/j.dnarep.2014.10.007. Epub 2014 Nov 15. PMID: 25454703 No abstract available.
57.	ARTD1 (PARP1) activation and NAD(+) in DNA repair and cell death. Fouquerel E, Sobol RW. DNA Repair (Amst). 2014 Nov;23:27-32. doi: 10.1016/j.dnarep.2014.09.004. Epub 2014 Oct 3. PMID: 25283336 Free PMC article. Review.
58.	ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents. Agnihotri S, Burrell K, Buczkowicz P, Remke M, Golbourn B, Chornenkyy Y, Gajadhar A, Fernandez NA, Clarke ID, Barszczyk MS, Pajovic S, Ternamian C, Head R, Sabha N, Sobol RW, Taylor MD, Rutka JT, Jones C, Dirks PB, Zadeh G, Hawkins C. Cancer Discov. 2014 Oct;4(10):1198-213. doi: 10.1158/2159-8290.CD-14-0157. Epub 2014 Aug 6. PMID: 25100205 Free PMC article.
59.	ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion. Fouquerel E, Goellner EM, Yu Z, Gagné JP, Barbi de Moura M, Feinstein T, Wheeler D, Redpath P, Li J, Romero G, Migaud M, Van Houten B, Poirier GG, Sobol RW. Cell Rep. 2014 Sep 25;8(6):1819-1831. doi: 10.1016/j.celrep.2014.08.036. Epub 2014 Sep 15. PMID: 25220464 Free PMC article.
60.	Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference. Bennett GR, Peters R, Wang XH, Hanne J, Sobol RW, Bundschuh R, Fishel R, Yoder KE. PLoS One. 2014 Jul 22;9(7):e103164. doi: 10.1371/journal.pone.0103164. eCollection 2014. PMID: 25051054 Free PMC article.
61.	Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin. Lan L, Nakajima S, Wei L, Sun L, Hsieh CL, Sobol RW, Bruchez M, Van Houten B, Yasui A, Levine AS. Nucleic Acids Res. 2014 Feb;42(4):2330-45. doi: 10.1093/nar/gkt1233. Epub 2013 Nov 29. PMID: 24293652 Free PMC article.
62.	Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair. Choi YJ, Li H, Son MY, Wang XH, Fornsaglio JL, Sobol RW, Lee M, Vijg J, Imholz S, Dollé ME, van Steeg H, Reiling E, Hasty P. PLoS One. 2014 Jan 23;9(1):e86358. doi: 10.1371/journal.pone.0086358. eCollection 2014. PMID: 24466051 Free PMC article.
63.	Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity. Kothandapani A, Sawant A, Dangeti VS, Sobol RW, Patrick SM. Nucleic Acids Res. 2013 Aug;41(15):7332-43. doi: 10.1093/nar/gkt479. Epub 2013 Jun 12. PMID: 23761438 Free PMC article.
64.	Base excision repair facilitates a functional relationship between Guanine oxidation and histone demethylation. Li J, Braganza A, Sobol RW. Antioxid Redox Signal. 2013 Jun 20;18(18):2429-43. doi: 10.1089/ars.2012.5107. Epub 2013 Feb 28. PMID: 23311711 Free PMC article. Review.
65.	MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. Joshi K, Banasavadi-Siddegowda Y, Mo X, Kim SH, Mao P, Kig C, Nardini D, Sobol RW, Chow LM, Kornblum HI, Waclaw R, Beullens M, Nakano I. Stem Cells. 2013 Jun;31(6):1051-63. doi: 10.1002/stem.1358. PMID: 23404835 Free PMC article.
66.	Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3. Mao P, Joshi K, Li J, Kim SH, Li P, Santana-Santos L, Luthra S, Chandran UR, Benos PV, Smith L, Wang M, Hu B, Cheng SY, Sobol RW, Nakano I. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8644-9. doi: 10.1073/pnas.1221478110. Epub 2013 May 6. PMID: 23650391 Free PMC article. Clinical Trial.
67.	Mutation research/fundamental and molecular mechanisms of mutagenesis: special issue: DNA repair and genetic instability. Williams K, Sobol RW. Mutat Res. 2013 Mar-Apr;743-744:1-3. doi: 10.1016/j.mrfmmm.2013.04.009. PMID: 23688353 Free PMC article. No abstract available.
68.	SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress. Nagaria P, Svilar D, Brown AR, Wang XH, Sobol RW, Wyatt MD. Mutat Res. 2013 Mar-Apr;743-744:26-32. doi: 10.1016/j.mrfmmm.2012.12.001. Epub 2012 Dec 17. PMID: 23253900 Free PMC article.
69.	Synthesis and characterization of DNA minor groove binding alkylating agents. Iyer P, Srinivasan A, Singh SK, Mascara GP, Zayitova S, Sidone B, Fouquerel E, Svilar D, Sobol RW, Bobola MS, Silber JR, Gold B. Chem Res Toxicol. 2013 Jan 18;26(1):156-68. doi: 10.1021/tx300437x. Epub 2012 Dec 26. PMID: 23234400 Free PMC article.
70.	Alkylation sensitivity screens reveal a conserved cross-species functionome. Svilar D, Dyavaiah M, Brown AR, Tang JB, Li J, McDonald PR, Shun TY, Braganza A, Wang XH, Maniar S, St Croix CM, Lazo JS, Pollack IF, Begley TJ, Sobol RW. Mol Cancer Res. 2012 Dec;10(12):1580-96. doi: 10.1158/1541-7786.MCR-12-0168. Epub 2012 Oct 4. PMID: 23038810 Free PMC article.
71.	Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors. Srinivasan A, Wang L, Cline CJ, Xie Z, Sobol RW, Xie XQ, Gold B. Biochemistry. 2012 Aug 7;51(31):6246-59. doi: 10.1021/bi300490r. Epub 2012 Jul 24. PMID: 22788932 Free PMC article.
72.	Quantitative, real-time analysis of base excision repair activity in cell lysates utilizing lesion-specific molecular beacons. Svilar D, Vens C, Sobol RW. J Vis Exp. 2012 Aug 6;(66):e4168. doi: 10.3791/4168. PMID: 22895410 Free PMC article.
73.	For MutY, it’s all about the OG. Sobol RW. Chem Biol. 2012 Mar 23;19(3):313-4. doi: 10.1016/j.chembiol.2012.03.002. PMID: 22444586 Free PMC article.
74.	Transcriptional profiling reveals elevated Sox2 in DNA polymerase ß null mouse embryonic fibroblasts. Li J, Luthra S, Wang XH, Chandran UR, Sobol RW. Am J Cancer Res. 2012;2(6):699-713. doi: 10.1158/1538-7445.am2012-699. Epub 2012 Nov 20. PMID: 23226616 Free PMC article.
75.	Genome instability caused by a germline mutation in the human DNA repair gene POLB. Sobol RW. PLoS Genet. 2012;8(11):e1003086. doi: 10.1371/journal.pgen.1003086. Epub 2012 Nov 8. PMID: 23144636 Free PMC article. No abstract available.
76.	Targeting DNA polymerase ß for therapeutic intervention. Goellner EM, Svilar D, Almeida KH, Sobol RW. Curr Mol Pharmacol. 2012 Jan;5(1):68-87. PMID: 22122465 Free PMC article. Review.
77.	XRCC1 and base excision repair balance in response to nitric oxide. Mutamba JT, Svilar D, Prasongtanakij S, Wang XH, Lin YC, Dedon PC, Sobol RW, Engelward BP. DNA Repair (Amst). 2011 Dec 10;10(12):1282-93. doi: 10.1016/j.dnarep.2011.10.008. Epub 2011 Oct 29. PMID: 22041025 Free PMC article.
78.	Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. Svilar D, Goellner EM, Almeida KH, Sobol RW. Antioxid Redox Signal. 2011 Jun 15;14(12):2491-507. doi: 10.1089/ars.2010.3466. Epub 2010 Oct 28. PMID: 20649466 Free PMC article. Review.
79.	Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. Li H, Wang P, Sun Q, Ding WX, Yin XM, Sobol RW, Stolz DB, Yu J, Zhang L. Cancer Res. 2011 May 15;71(10):3625-34. doi: 10.1158/0008-5472.CAN-10-4475. Epub 2011 Mar 28. PMID: 21444671 Free PMC article.
80.	N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide. Tang JB, Svilar D, Trivedi RN, Wang XH, Goellner EM, Moore B, Hamilton RL, Banze LA, Brown AR, Sobol RW. Neuro Oncol. 2011 May;13(5):471-86. doi: 10.1093/neuonc/nor011. Epub 2011 Mar 3. PMID: 21377995 Free PMC article.
81.	Novel role of base excision repair in mediating cisplatin cytotoxicity. Kothandapani A, Dangeti VS, Brown AR, Banze LA, Wang XH, Sobol RW, Patrick SM. J Biol Chem. 2011 Apr 22;286(16):14564-74. doi: 10.1074/jbc.M111.225375. Epub 2011 Feb 28. PMID: 21357694 Free PMC article.
82.	MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck. Langevin SM, Stone RA, Bunker CH, Lyons-Weiler MA, LaFramboise WA, Kelly L, Seethala RR, Grandis JR, Sobol RW, Taioli E. Cancer. 2011 Apr 1;117(7):1454-62. doi: 10.1002/cncr.25689. Epub 2010 Nov 8. PMID: 21425146 Free PMC article.
83.	The base excision repair pathway is required for efficient lentivirus integration. Yoder KE, Espeseth A, Wang XH, Fang Q, Russo MT, Lloyd RS, Hazuda D, Sobol RW, Fishel R. PLoS One. 2011 Mar 23;6(3):e17862. doi: 10.1371/journal.pone.0017862. PMID: 21448280 Free PMC article.
84.	Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair. Goellner EM, Grimme B, Brown AR, Lin YC, Wang XH, Sugrue KF, Mitchell L, Trivedi RN, Tang JB, Sobol RW. Cancer Res. 2011 Mar 15;71(6):2308-17. doi: 10.1158/0008-5472.CAN-10-3213. PMID: 21406402 Free PMC article.
85.	A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples. Lisovich A, Chandran UR, Lyons-Weiler MA, LaFramboise WA, Brown AR, Jakacki RI, Pollack IF, Sobol RW. BMC Med Genomics. 2011 Jan 26;4:14. doi: 10.1186/1755-8794-4-14. PMID: 21269491 Free PMC article.
86.	IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children’s Oncology Group. Pollack IF, Hamilton RL, Sobol RW, Nikiforova MN, Lyons-Weiler MA, LaFramboise WA, Burger PC, Brat DJ, Rosenblum MK, Holmes EJ, Zhou T, Jakacki RI; Children’s Oncology Group. Childs Nerv Syst. 2011 Jan;27(1):87-94. doi: 10.1007/s00381-010-1264-1. Epub 2010 Aug 20. PMID: 20725730 Free PMC article.
87.	Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant gliomas: a report from the Children’s Oncology Group. Pollack IF, Hamilton RL, Sobol RW, Nikiforova MN, Nikiforov YE, Lyons-Weiler MA, LaFramboise WA, Burger PC, Brat DJ, Rosenblum MK, Gilles FH, Yates AJ, Zhou T, Cohen KJ, Finlay JL, Jakacki RI; Children’s Oncology Group. Pediatr Blood Cancer. 2010 Dec 1;55(6):1066-71. doi: 10.1002/pbc.22634. PMID: 20589656 Free PMC article.
88.	MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index. Langevin SM, Stone RA, Bunker CH, Grandis JR, Sobol RW, Taioli E. Carcinogenesis. 2010 May;31(5):864-70. doi: 10.1093/carcin/bgq051. Epub 2010 Mar 2. PMID: 20197299 Free PMC article.
89.	Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage. Jelezcova E, Trivedi RN, Wang XH, Tang JB, Brown AR, Goellner EM, Schamus S, Fornsaglio JL, Sobol RW. Mutat Res. 2010 Apr 1;686(1-2):57-67. doi: 10.1016/j.mrfmmm.2010.01.016. Epub 2010 Jan 22. PMID: 20096707 Free PMC article.
90.	DNA polymerase beta-dependent long patch base excision repair in living cells. Asagoshi K, Liu Y, Masaoka A, Lan L, Prasad R, Horton JK, Brown AR, Wang XH, Bdour HM, Sobol RW, Taylor JS, Yasui A, Wilson SH. DNA Repair (Amst). 2010 Feb 4;9(2):109-19. doi: 10.1016/j.dnarep.2009.11.002. Epub 2009 Dec 16. PMID: 20006562 Free PMC article.
91.	Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage. Tang JB, Goellner EM, Wang XH, Trivedi RN, St Croix CM, Jelezcova E, Svilar D, Brown AR, Sobol RW. Mol Cancer Res. 2010 Jan;8(1):67-79. doi: 10.1158/1541-7786.MCR-09-0411. Epub 2010 Jan 12. PMID: 20068071 Free PMC article.
92.	Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase. Jones LE Jr, Ying L, Hofseth AB, Jelezcova E, Sobol RW, Ambs S, Harris CC, Espey MG, Hofseth LJ, Wyatt MD. Carcinogenesis. 2009 Dec;30(12):2123-9. doi: 10.1093/carcin/bgp256. PMID: 19864471 Free PMC article.
93.	Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation. Taioli E, Ragin C, Wang XH, Chen J, Langevin SM, Brown AR, Gollin SM, Garte S, Sobol RW. BMC Cancer. 2009 Oct 6;9:354. doi: 10.1186/1471-2407-9-354. PMID: 19807915 Free PMC article.
94.	Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. Yoshizawa K, Jelezcova E, Brown AR, Foley JF, Nyska A, Cui X, Hofseth LJ, Maronpot RM, Wilson SH, Sepulveda AR, Sobol RW. PLoS One. 2009 Aug 5;4(8):e6493. doi: 10.1371/journal.pone.0006493. PMID: 19654874 Free PMC article.
95.	Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1. Ueda R, Kohanbash G, Sasaki K, Fujita M, Zhu X, Kastenhuber ER, McDonald HA, Potter DM, Hamilton RL, Lotze MT, Khan SA, Sobol RW, Okada H. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10746-51. doi: 10.1073/pnas.0811817106. Epub 2009 Jun 11. PMID: 19520829 Free PMC article.
96.	Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice. Allen D, Herbert DC, McMahan CA, Rotrekl V, Sobol RW, Wilson SH, Walter CA. Biol Reprod. 2008 Nov;79(5):824-31. doi: 10.1095/biolreprod.108.069104. Epub 2008 Jul 23. PMID: 18650495 Free PMC article.
97.	Human methyl purine DNA glycosylase and DNA polymerase beta expression collectively predict sensitivity to temozolomide. Trivedi RN, Wang XH, Jelezcova E, Goellner EM, Tang JB, Sobol RW. Mol Pharmacol. 2008 Aug;74(2):505-16. doi: 10.1124/mol.108.045112. Epub 2008 May 13. PMID: 18477668 Free PMC article.
98.	Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. Kronenberg G, Harms C, Sobol RW, Cardozo-Pelaez F, Linhart H, Winter B, Balkaya M, Gertz K, Gay SB, Cox D, Eckart S, Ahmadi M, Juckel G, Kempermann G, Hellweg R, Sohr R, Hörtnagl H, Wilson SH, Jaenisch R, Endres M. J Neurosci. 2008 Jul 9;28(28):7219-30. doi: 10.1523/JNEUROSCI.0940-08.2008. PMID: 18614692 Free PMC article.
99.	CHIPping away at base excision repair. Sobol RW. Mol Cell. 2008 Feb 29;29(4):413-5. doi: 10.1016/j.molcel.2008.02.004. PMID: 18313379
100.	A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification. Almeida KH, Sobol RW. DNA Repair (Amst). 2007 Jun 1;6(6):695-711. doi: 10.1016/j.dnarep.2007.01.009. Epub 2007 Mar 6. PMID: 17337257 Free PMC article. Review.
101.	Overexpression of Dicer in precursor lesions of lung adenocarcinoma. Chiosea S, Jelezcova E, Chandran U, Luo J, Mantha G, Sobol RW, Dacic S. Cancer Res. 2007 Mar 1;67(5):2345-50. doi: 10.1158/0008-5472.CAN-06-3533. PMID: 17332367
102.	DNA polymerase beta null mouse embryonic fibroblasts harbor a homozygous null mutation in DNA polymerase iota. Sobol RW. DNA Repair (Amst). 2007 Jan 4;6(1):3-7. doi: 10.1016/j.dnarep.2006.08.005. Epub 2006 Sep 18. PMID: 16979388 Free PMC article. No abstract available.
103.	Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma. Chiosea S, Jelezcova E, Chandran U, Acquafondata M, McHale T, Sobol RW, Dhir R. Am J Pathol. 2006 Nov;169(5):1812-20. doi: 10.2353/ajpath.2006.060480. PMID: 17071602 Free PMC article.
104.	O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort. Pollack IF, Hamilton RL, Sobol RW, Burnham J, Yates AJ, Holmes EJ, Zhou T, Finlay JL. J Clin Oncol. 2006 Jul 20;24(21):3431-7. doi: 10.1200/JCO.2006.05.7265. PMID: 16849758
105.	The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death. Trivedi RN, Almeida KH, Fornsaglio JL, Schamus S, Sobol RW. Cancer Res. 2005 Jul 15;65(14):6394-400. doi: 10.1158/0008-5472.CAN-05-0715. PMID: 16024643
106.	Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. Endres M, Biniszkiewicz D, Sobol RW, Harms C, Ahmadi M, Lipski A, Katchanov J, Mergenthaler P, Dirnagl U, Wilson SH, Meisel A, Jaenisch R. J Clin Invest. 2004 Jun;113(12):1711-21. doi: 10.1172/JCI20926. PMID: 15199406 Free PMC article.
107.	Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. Sobol RW, Kartalou M, Almeida KH, Joyce DF, Engelward BP, Horton JK, Prasad R, Samson LD, Wilson SH. J Biol Chem. 2003 Oct 10;278(41):39951-9. doi: 10.1074/jbc.M306592200. Epub 2003 Jul 25. PMID: 12882965
108.	Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens. Cabelof DC, Guo Z, Raffoul JJ, Sobol RW, Wilson SH, Richardson A, Heydari AR. Cancer Res. 2003 Sep 15;63(18):5799-807. PMID: 14522902
109.	Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice. Sobol RW, Foley JF, Nyska A, Davidson MG, Wilson SH. DNA Repair (Amst). 2003 May 13;2(5):609-22. doi: 10.1016/s1568-7864(03)00026-0. PMID: 12713817
110.	Binary system for selective photoaffinity labeling of base excision repair DNA polymerases. Lavrik OI, Kolpashchikov DM, Prasad R, Sobol RW, Wilson SH. Nucleic Acids Res. 2002 Jul 15;30(14):e73. doi: 10.1093/nar/gnf073. PMID: 12136121 Free PMC article.
111.	Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Sobol RW, Watson DE, Nakamura J, Yakes FM, Hou E, Horton JK, Ladapo J, Van Houten B, Swenberg JA, Tindall KR, Samson LD, Wilson SH. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6860-5. doi: 10.1073/pnas.092662499. Epub 2002 Apr 30. PMID: 11983862 Free PMC article.
112.	Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage. Horton JK, Baker A, Berg BJ, Sobol RW, Wilson SH. DNA Repair (Amst). 2002 Apr 29;1(4):317-33. doi: 10.1016/s1568-7864(02)00008-3. PMID: 12509250
113.	DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage. Tomicic MT, Thust R, Sobol RW, Kaina B. Cancer Res. 2001 Oct 15;61(20):7399-403. PMID: 11606369
114.	Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair. Lavrik OI, Prasad R, Sobol RW, Horton JK, Ackerman EJ, Wilson SH. J Biol Chem. 2001 Jul 6;276(27):25541-8. doi: 10.1074/jbc.M102125200. Epub 2001 May 4. PMID: 11340072
115.	The response of human breast tumour cell lines with altered polymerase beta levels to cisplatin and radiation. Raaphorst GP, Cybulski SE, Sobol R, Ng CE. Anticancer Res. 2001 May-Jun;21(3B):2079-83. PMID: 11497301
116.	Mammalian DNA beta-polymerase in base excision repair of alkylation damage. Sobol RW, Wilson SH. Prog Nucleic Acid Res Mol Biol. 2001;68:57-74. doi: 10.1016/s0079-6603(01)68090-5. PMID: 11554313 Review.
117.	The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity. Sobol RW, Prasad R, Evenski A, Baker A, Yang XP, Horton JK, Wilson SH. Nature. 2000 Jun 15;405(6788):807-10. doi: 10.1038/35015598. PMID: 10866204
118.	DNA polymerase beta and mammalian base excision repair. Wilson SH, Sobol RW, Beard WA, Horton JK, Prasad R, Vande Berg BJ. Cold Spring Harb Symp Quant Biol. 2000;65:143-55. doi: 10.1101/sqb.2000.65.143. PMID: 12760029 Review. No abstract available.
119.	Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage. Ochs K, Sobol RW, Wilson SH, Kaina B. Cancer Res. 1999 Apr 1;59(7):1544-51. PMID: 10197627
120.	Selective mRNA degradation by antisense oligonucleotide-2,5A chimeras: involvement of RNase H and RNase L. Robbins I, Mitta G, Vichier-Guerre S, Sobol R, Ubysz A, Rayner B, Lebleu B. Biochimie. 1998 Aug-Sep;80(8-9):711-20. doi: 10.1016/s0300-9084(99)80024-8. PMID: 9865493
121.	Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines. Chen KH, Yakes FM, Srivastava DK, Singhal RK, Sobol RW, Horton JK, Van Houten B, Wilson SH. Nucleic Acids Res. 1998 Apr 15;26(8):2001-7. doi: 10.1093/nar/26.8.2001. PMID: 9518496 Free PMC article.
122.	Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells. Fortini P, Pascucci B, Parlanti E, Sobol RW, Wilson SH, Dogliotti E. Biochemistry. 1998 Mar 17;37(11):3575-80. doi: 10.1021/bi972999h. PMID: 9530283
123.	Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA. Biade S, Sobol RW, Wilson SH, Matsumoto Y. J Biol Chem. 1998 Jan 9;273(2):898-902. doi: 10.1074/jbc.273.2.898. PMID: 9422747
124.	Requirement of mammalian DNA polymerase-beta in base-excision repair. Sobol RW, Horton JK, Kühn R, Gu H, Singhal RK, Prasad R, Rajewsky K, Wilson SH. Nature. 1996 Jan 11;379(6561):183-6. doi: 10.1038/379183a0. PMID: 8538772
125.	Inhibition of HIV-1 replication and activation of RNase L by phosphorothioate/phosphodiester 2′,5′-oligoadenylate derivatives. Sobol RW, Henderson EE, Kon N, Shao J, Hitzges P, Mordechai E, Reichenbach NL, Charubala R, Schirmeister H, Pfleiderer W, et al. J Biol Chem. 1995 Mar 17;270(11):5963-78. doi: 10.1074/jbc.270.11.5963. PMID: 7890727
126.	Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome. Suhadolnik RJ, Reichenbach NL, Hitzges P, Sobol RW, Peterson DL, Henry B, Ablashi DV, Müller WE, Schröder HC, Carter WA, et al. Clin Infect Dis. 1994 Jan;18 Suppl 1:S96-104. doi: 10.1093/clinids/18.supplement_1.s96. PMID: 8148461 Clinical Trial.
127.	HIV-1 reverse transcriptase: inhibition by 2′,5′-oligoadenylates. Sobol RW, Fisher WL, Reichenbach NL, Kumar A, Beard WA, Wilson SH, Charubala R, Pfleiderer W, Suhadolnik RJ. Biochemistry. 1993 Nov 16;32(45):12112-8. doi: 10.1021/bi00096a023. PMID: 7692966
128.	Mapping of nucleic acid binding in proteolytic domains of HIV-1 reverse transcriptase. Kumar A, Kim HR, Sobol RW, Becerra SP, Lee BJ, Hatfield DL, Suhadolnik RJ, Wilson SH. Biochemistry. 1993 Jul 27;32(29):7466-74. doi: 10.1021/bi00080a018. PMID: 7687875
129.	Chemical synthesis and biological characterization of phosphorothioate analogs of 2′, 5′-3′-deoxyadenylate trimer. Sobol RW, Charubala R, Pfleiderer W, Suhadolnik RJ. Nucleic Acids Res. 1993 May 25;21(10):2437-43. doi: 10.1093/nar/21.10.2437. PMID: 7685081 Free PMC article.
130.	Localization of a polynucleotide binding region in the HIV-1 reverse transcriptase: implications for primer binding. Sobol RW, Suhadolnik RJ, Kumar A, Lee BJ, Hatfield DL, Wilson SH. Biochemistry. 1991 Nov 5;30(44):10623-31. doi: 10.1021/bi00108a004. PMID: 1718424
131.	Heterogeneous nuclear RNA from hairy cell leukemia patients activates 2′,5′-oligoadenylate synthetase. Hubbell HR, Sheetz PC, Iogal SS, Brodsky I, Kariko K, Li SW, Suhadolnik RJ, Sobol RW. Anticancer Res. 1991 Sep-Oct;11(5):1927-32. PMID: 1768064
132.	Purine 8-substitution modulates the ribonuclease L binding and activation abilities of 2′,5′-oligoadenylates. Kanou M, Ohomori H, Nagai K, Yokoyama S, Suhadolnik RJ, Sobol R Jr, Takaku H. Biochem Biophys Res Commun. 1991 Apr 30;176(2):769-74. doi: 10.1016/s0006-291x(05)80251-7. PMID: 2025289
133.	Cordycepin analogues of 2′,5′-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase. Müller WE, Weiler BE, Charubala R, Pfleiderer W, Leserman L, Sobol RW, Suhadolnik RJ, Schröder HC. Biochemistry. 1991 Feb 26;30(8):2027-33. doi: 10.1021/bi00222a004. PMID: 1705437
134.	Chemical synthesis and biological activities of analogues of 2′,5′-oligoadenylates containing 8-substituted adenosine derivatives. Kanou M, Ohomori H, Takaku H, Yokoyama S, Kawai G, Suhadolnik RJ, Sobol R Jr. Nucleic Acids Res. 1990 Aug 11;18(15):4439-46. doi: 10.1093/nar/18.15.4439. PMID: 2167468 Free PMC article.
135.	2′,5′ A synthetase: allosteric activation by fructose 1,6-bisphosphate. Suhadolnik RJ, Li SW, Sobol RW, Varnum JM. Biochem Biophys Res Commun. 1990 Jun 29;169(3):1198-203. doi: 10.1016/0006-291x(90)92023-s. PMID: 2363721
136.	Phosphorothioate analogues of (2′-5′)(A)4: agonist and antagonist activities in intact cells. Charachon G, Sobol RW, Bisbal C, Salehzada T, Silhol M, Charubala R, Pfleiderer W, Lebleu B, Suhadolnik RJ. Biochemistry. 1990 Mar 13;29(10):2550-6. doi: 10.1021/bi00462a017. PMID: 2159324
137.	Phosphorothioate and cordycepin analogues of 2′,5′-oligoadenylate: inhibition of human immunodeficiency virus type 1 reverse transcriptase and infection in vitro. Montefiori DC, Sobol RW Jr, Li SW, Reichenbach NL, Suhadolnik RJ, Charubala R, Pfleiderer W, Modliszewski A, Robinson WE Jr, Mitchell WM. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7191-4. doi: 10.1073/pnas.86.18.7191. PMID: 2476814 Free PMC article.
138.	2- and 8-azido photoaffinity probes. 1. Enzymatic synthesis, characterization, and biological properties of 2- and 8-azido photoprobes of 2-5A and photolabeling of 2-5A binding proteins. Suhadolnik RJ, Karikó K, Sobol RW Jr, Li SW, Reichenbach NL, Haley BE. Biochemistry. 1988 Nov 29;27(24):8840-6. doi: 10.1021/bi00424a023. PMID: 3242613
139.	2- and 8-azido photoaffinity probes. 2. Studies on the binding process of 2-5A synthetase by photosensitive ATP analogues. Suhadolnik RJ, Li SW, Sobol RW Jr, Haley BE. Biochemistry. 1988 Nov 29;27(24):8846-51. doi: 10.1021/bi00424a024. PMID: 2853970
140.	Phosphorothioate analogues of 2′,5′-oligoadenylate. Activation of 2′,5′-oligoadenylate-dependent endoribonuclease by 2′,5′-phosphorothioate cores and 5′-monophosphates. Karikó K, Li SW, Sobol RW Jr, Suhadolnik RJ, Charubala R, Pfleiderer W. Biochemistry. 1987 Nov 3;26(22):7136-42. doi: 10.1021/bi00396a040. PMID: 3427063
141.	Phosphorothioate analogues of 2′,5′-oligoadenylate. Enzymatically synthesized 2′,5′-phosphorothioate dimer and trimer: unequivocal structural assignment and activation of 2′,5′-oligoadenylate-dependent endoribonuclease. Karikó K, Sobol RW Jr, Suhadolnik L, Li SW, Reichenbach NL, Suhadolnik RJ, Charubala R, Pfleiderer W. Biochemistry. 1987 Nov 3;26(22):7127-35. doi: 10.1021/bi00396a039. PMID: 3427062

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