Publications

2023

Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator.
Abdelfattah, A. S., Zheng, J., Singh, A., Huang, Y. C., Reep, D., Tsegaye, G., Tsang, A., Arthur, B. J., Rehorova, M., Olson, C. V. L., Shuai, Y., Zhang, L., Fu, T. M., Milkie, D. E., Moya, M. V., Weber, T. D., Lemire, A., Baker, C. A., Falco, N., Zheng, Q., Grimm, J. B., Yip, M. C., Walpita, D., Chase, M., Campagnola, L., Murphy, G. J., Wong, A. M., Forest, C. R., Mertz, J., Economo, M. N., Turner, G. C., Koyama, M., Lin, B. J., Betzig, E., Novak, O., Lavis, L. D., Svoboda, K., Korff, W., Chen, T. W., Schreiter, E. R., Hasseman, J. P., Kolb, I.
Neuron. 2023. 111, 1547-1563.e9, doi: 10.1016/j.neuron.2023.03.009

2022

Fluorescent Reporters for Sensing Membrane Potential: Tools for Bioelectricity
R. H. Kramer, E. W. Miller, A.S. Abdelfattah, B. Baker
Bioelectricity. 2022. 4, 108–116. doi: 10.1089/bioe.2022.0017

Neurophotonic tools for microscopic measurements and manipulation: status report.
Abdelfattah, A. S., Ahuja, S., Akkin, T., Rao Allu, S., Brake, J., Boas, D. A., Buckley, E. M., Campbell, R. E., Chen, A. I., Cheng, X., Čižmár, T., Costantini, I., De Vittorio, M., Devor, A., Doran, P. R., Khatib, M. El, Emiliani, V., Fomin-Thunemann, N., Fainman, Y., Fernandez-Alfonso, T., Ferri, C. G. L., Gilad, A., Han, X., Harris, A., Hillman, E. M. C., Hochgeschwender, U., Holt, M. G., Ji, N., Kılıç, K., Lake, E. M. R., Li, L., Li, T., Mächler, P., Miller, E. W., Mesquita, R. C., Naga, K. M., Nadella, S., Nägerl, U. V., Nasu, Y., Nimmerjahn, A., Ondráčková, P., Pavone, F. S., Campos, C. P., Peterka, D. S., Pisano, F., Pisanello, F., Puppo, F., Sabatini, B. L., Sadegh, S., Sakadzic, S., Shoham, S., Shroff, S. N., Silver, R. A., Sims, R. R., Smith, S. L., Srinivasan, V. J., Thunemann, M., Tian, L., Tian, L., Troxler, T., Valera, A., Vaziri, A., Vinogradov, S. A., Vitale, F., Wang, L. V, Uhlířová, H., Xu, C., Yang, C., Yang, M.-H., Yellen, G., Yizhar, O., Zhao, Y.
Neurophotonics. 2022. 9, 013001, doi: 10.1117/1.NPh.9.S1.013001

2021

Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator.
A. S. Abdelfattah*, J. Zheng, D. Reep, G. Tsegaye, A. Tsang, B. J. Arthur, M. Rehorova, C. V. L. Olson, Y.-C. Huang, Y. Shuai, M. Koyama, M. V Moya, T. D. Weber, A. L. Lemire, C. A. Baker, N. Falco, Q. Zheng, J. B. Grimm, M. C. Yip, D. Walpita, C. R. Forest, M. Chase, L. Campagnola, G. Murphy, A. M. Wong, J. Mertz, M. N. Economo, G. Turner, B-J. Lin, T-W. Chen, O. Novak, L. D. Lavis, K. Svoboda, E. R. Schreiter*, J. Hasseman*, I. Kolb*
bioRxiv. 2021. 467909. doi:1101/2021.11.09.467909
(*corresponding authors)

The HaloTag as a general scaffold for far-red tunable chemigenetic indicators.
Deo, C.*, Abdelfattah, A. S.*, Bhargava, H. K., Berro, A. J., Falco, N., Farrants, H., Moeyaert, B., Chupanova, M., Lavis, L. D., Schreiter, E. R.
Nature Chemical Biology. 2021. doi:10.1038/s41589-021-00775-w
(*co-first authors)

2020

A general approach to engineer positive-going eFRET voltage indicators. 
Abdelfattah, A. S.*, Valenti, R., Zheng, J., Wong, A., Koyama, M., Kim, D. S. & Schreiter, E. R*.
Nature Communications. 2020. 11, 3444. doi:1038/s41467-020-17322-1
(*corresponding authors)

2019

Bright and photostable chemigenetic indicators for extended in vivo voltage imaging.
Abdelfattah, A. S., Kawashima, T., Singh, A., Novak, O., Liu, H., Shuai, Y., Huang, Y.-C., Campagnola, L., Seeman, S. C., Yu, J., Zheng, J., Grimm, J. B., Patel, R., Friedrich, J., Mensh, B. D., Paninski, L., Macklin, J. J., Murphy, G. J., Podgorski, K., Lin, B.-J., Chen, T.-W., Turner, G. C., Liu, Z., Koyama, M., Svoboda, K., Ahrens, M. B., Lavis, L. D. & Schreiter, E. R.
Science. 2019. 365, 699–704. doi:10.1126/science.aav6416

rsCaMPARI: An erasable marker of neuronal activity.
Sha, F., Abdelfattah, A. S., Patel, R., Schreiter, E. R.
bioRxiv. 2019. 798298. doi:1101/798298

Kilohertz frame-rate two-photon tomography.
Kazemipour, A., Novak, O., Flickinger, D., Marvin, J. S., Abdelfattah, A. S., King, J., Borden, P. M., Kim, J. J., Al-Abdullatif, S. H., Deal, P. E., Miller, E. W., Schreiter, E. R., Druckmann, S., Svoboda, K., Looger, L. L. & Podgorski, K.
Nature Methods. 2019. 16, 778-786. doi:1038/s41592-019-0493-9

A genetically encoded near-infrared fluorescent calcium ion indicator.
Qian, Y., Piatkevich, K. D., Mc Larney, B., Abdelfattah, A. S., Mehta, S., Murdock, M. H., Gottschalk, S., Molina, R. S., Zhang, W., Chen, Y., Wu, J., Drobizhev, M., Hughes, T. E., Zhang, J., Schreiter, E. R., Shoham, S., Razansky, D., Boyden, E. S. & Campbell, R. E.
Nature Methods. 2019. 16, 171–174. doi:1038/s41592-018-0294-6

Wide-area all-optical neurophysiology in acute brain slices.
Farhi, S. L., Parot, V. J., Grama, A., Yamagata, M., Abdelfattah, A. S., Adam, Y., Lou, S., Jun Kim, J., Campbell, R. E., Cox, D. D. & Cohen, A. E.
The Journal of Neuroscince. 2019. 39, 4889−4908. doi:10.1523/jneurosci.0168-19.2019

2018

Genetically Encoded Glutamate Indicators with Altered Color and Topology.
Wu, J., Abdelfattah, A. S., Zhou, H., Ruangkittisakul, A., Qian, Y., Ballanyi, K. & Campbell, R. E.
ACS Chemical Biology. 2018. 13, 1832−1837. doi:1021/acschembio.7b01085

A genetically encoded Ca2+ indicator based on circularly permutated sea anemone red fluorescent protein eqFP578.
Shen, Y., Dana, H., Abdelfattah, A. S., Patel, R., Shea, J., Molina, R. S., Rawal, B., Rancic, V., Chang, Y.-F., Wu, L., Chen, Y., Qian, Y., Wiens, M. D., Hambleton, N., Ballanyi, K., Hughes, T. E., Drobizhev, M., Kim, D. S., Koyama, M., Schreiter, E. R. & Campbell, R. E.
BMC Biology. 2018. 16, 9. doi:1186/s12915-018-0480-0

2016

A bright and fast red fluorescent protein voltage indicator that reports neuronal activity in organotypic brain slices.
Abdelfattah, A. S., Farhi, S. L., Zhao, Y., Brinks, D., Zou, P., Ruangkittisakul, A., Platisa, J., Pieribone, V. A., Ballanyi, K., Cohen, A. E. & Campbell, R. E.
The Journal of Neuroscience. 2016. 36, 2458–2472. doi:10.1523/jneurosci.3484-15.2016

Ratiometric and photoconvertible fluorescent protein-based voltage indicator prototypes.
Abdelfattah, A. S., Rancic, V., Rawal, B., Ballanyi, K. & Campbell, R. E.
Chemical Communications. 2016. 104, 40–50. doi:10.1039/c6cc06810c

2014

A long Stokes shift red fluorescent Ca2+ indicator protein for two-photon and ratiometric imaging.
Wu, J., Abdelfattah, A. S., Miraucourt, L. S., Kutsarova, E., Ruangkittisakul, A., Zhou, H., Ballanyi, K., Wicks, G., Drobizhev, M., Rebane, A., Ruthazer, E. S. & Campbell, R. E.
Nature Communications. 2014. 5, 5262. doi:10.1038/ncomms6262

Microfluidic cell sorter-aided directed evolution of a protein-based calcium ion indicator with an inverted fluorescent response.
Zhao, Y., Abdelfattah, A. S., Zhao, Y., Ruangkittisakul, A., Ballanyi, K., Campbell, R. E. & Harrison, D. J.
Integrative Biology. 2014. 6, 714–25. doi:10.1039/c4ib00039k

2012

A fluorogenic red fluorescent protein heterodimer.
Alford, S. C., Abdelfattah, A. S., Ding, Y. & Campbell, R. E.
Chemistry & Biology. 2012. 19, 353–360. doi:10.1016/j.chembiol.2012.01.006

2011

An expanded palette of genetically encoded Ca2+ indicators.
Zhao, Y., Araki, S., Wu, J., Teramoto, T., Chang, Y.-F., Nakano, M., Abdelfattah, A. S., Fujiwara, M., Ishihara, T., Nagai, T. & Campbell, R. E.
Science. 2011. 333, 1888–1891. doi:10.1126/science.1208592