Our laboratory seeks to understand how T cells integrate diverse local microbial and environmental stimuli at mucosal sites to shape distinct, dynamic, immune processes in health and disease. T cells are a key component of host defense against pathogenic infection in barrier mucosal surfaces, which are common sites of microbial entry. Often these potent, anti-pathogenic inflammatory responses need to be tightly regulated to maintain barrier integrity and vital physiologic functions. The mucosal immune system in the female reproductive tract (FRT) has evolved to mount a robust anti-pathogen defense while maintaining tolerance towards an immunologically foreign fetus. Thus, the FRT provides a unique model system to study T cell adaptation to diverse environmental inputs. Our research program is aimed to develop a more complete understanding of the fundamental biology of T cells in the reproductive mucosae. Furthermore, we seek to apply this knowledge to informing improved vaccination strategies, develop novel therapies against infection and malignancy and to advance maternal-fetal health.
We are now accepting rotation students. Interested applicants affiliated with the Pathobiology graduate program (https://www.brown.edu/academics/biomed/pathobiology/home) and MCB graduate program (https://www.brown.edu/academics/biology/molecular-cell-biochemistry/graduate/home) should directly contact Lalit at Lalit_Beura@brown.edu.