Publications

Borys, Samantha & Bag, Arup & Brossay, Laurent & Adeegbe, Dennis. (2022). The Yin and Yang of Targeting KLRG1+ Tregs and Effector Cells. Frontiers in Immunology. 13. 894508. 10.3389/fimmu.2022.894508.

 

 

McNamara, J.T., Huntington, K.E., Borys, S. et al. SHP-2 deletion in CD4Cre expressing chondrocyte precursors leads to tumor development with wrist tropism. Sci Rep 11, 20006 (2021). https://doi.org/10.1038/s41598-021-99339-0

 

Angela Tata, Garvin Dodard, Céline Fugère, Corinne Leget, Mélody Ors, Benjamin Rossi, Eric Vivier & Laurent Brossay (2021) Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers, OncoImmunology, 10:1, DOI: 10.1080/2162402X.2021.1933808

 

 

Anderson, C. K., Reilly, S. P., & Brossay, L. (2020). The Invariant NKT Cell Response Has Differential Signaling Requirements during Antigen-Dependent and Antigen-Independent Activation. The Journal of Immunology, ji2000870. https://doi.org/10.4049/jimmunol.2000870

 

 

Seillet, C., Brossay, L., & Vivier, E. (2021). ScienceDirect Natural killers or ILC1s ? That is the question. Current Opinion in Immunology, 68, 48–53. https://doi.org/10.1016/j.coi.2020.08.009

 

 

 

Dodard, G., Tata, A., Erick, T. K., Jaime, D., Miah, S. M. S., Quatrini, L., Escaliere, B., Ugolini, S., Vivier, E., Brossay, L. Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells. Cell Rep. 2020 July 7; 32(1). https://doi.org/10.1016/j.celrep.2020.107855

 

 

Anderson CK, Reilly EC, Lee AY, Brossay L. Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection. Cell Rep. 2019 Apr 9;27(2):537-548.e5. doi: 10.1016/j.celrep.2019.03.059. PubMed PMID: 30970256; PubMed Central PMCID: PMC6472915.

 

Niogret C, Miah SMS, Rota G, Fonta NP, Wang H, Held W, Birchmeier W, Sexl V, Yang W, Vivier E, Ho PC, Brossay L, Guarda G. Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells. Nat Commun. 2019 Mar 29;10(1):1444. doi: 10.1038/s41467-019-09431-3. PubMed PMID: 30926899; PubMed Central PMCID: PMC6441079.

 

 

Miah SMS, Jayasuriya CT, Salter AI, Reilly EC, Fugere C, Yang W, Chen Q, Brossay L. Ptpn11 Deletion in CD4+ Cells Does Not  Affect T Cell Development and Functions but Causes Cartilage Tumors in a T Cell-Independent Manner. Front Immunol. 2017;8:1326. doi: 10.3389/fimmu.2017.01326. eCollection 2017. PubMed PMID: 29085371; PubMed Central PMCID: PMC5650614.

 

 

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Anderson CK, Brossay L. The role of MHC class Ib-restricted T cells during infection. Immunogenetics. 2016 Aug;68(8):677-91. doi: 10.1007/s00251-016-0932-z. Epub 2016 Jul 1. Review. PubMed PMID: 27368413; PubMed Central PMCID: PMC5003733.

 

Phenotype and functions of conventional and non-conventional NK cells. Curr Opin Immunol. 2016 Feb;38:67-74. doi: 10.1016/j.coi.2015.11.007. Epub 2015 Dec 17. Review. PubMed PMID: 26706497; PubMed Central PMCID: PMC4715908.

 

Erick T, Grigoryan L, Brossay L. Lacrimal Gland NK Cells Are Developmentally and Functionally Similar to Conventional NK  Cells. Immunohorizons. 2017 Apr 1;1(2):2-9. doi:10.4049/immunohorizons.1700008. PubMed PMID: 28966997; PubMed Central PMCID: PMC5616209.

 

Erick TK, Anderson CK, Reilly EC, Wands JR, Brossay L. NFIL3 Expression Distinguishes Tissue-Resident NK Cells and Conventional NK-like Cells in the Mouse Submandibular Glands. J Immunol. 2016 Sep 15;197(6):2485-91. doi: 10.4049/jimmunol.1601099. Epub 2016 Aug 12. PubMed PMID: 27521341; PubMed Central PMCID: PMC5010994.

 

Anderson CK, Salter AI, Toussaint LE, Reilly EC, Fugère C, Srivastava N, Kerr WG, Brossay L. Role of SHIP1 in Invariant NKT Cell Development and Functions. J Immunol. 2015 Sep 1;195(5):2149-2156. doi: 10.4049/jimmunol.1500567. Epub 2015 Jul 31. PubMed PMID: 26232432; PubMed Central PMCID: PMC4546909.

 

Guan J, Miah SM, Wilson ZS, Erick TK, Banh C, Brossay L. Role of type I interferon receptor signaling on NK cell development and functions. PLoS One. 2014;9(10):e111302. doi: 10.1371/journal.pone.0111302. eCollection 2014. PubMed PMID: 25333658; PubMed Central PMCID: PMC4205023.

 

Banh C, Miah SM, Kerr WG, Brossay L. Mouse natural killer cell development and maturation are differentially regulated by SHIP-1. Blood. 2012 Nov 29;120(23):4583-90. doi: 10.1182/blood-2012-04-425009. Epub 2012 Oct 3. PubMed PMID: 23034281; PubMed Central PMCID: PMC3512235.

 

Reilly EC, Thompson EA, Aspeslagh S, Wands JR, Elewaut D, Brossay L. Activated iNKT cells promote memory CD8+ T cell differentiation during viral infection. PLoS One. 2012;7(5):e37991. doi: 10.1371/journal.pone.0037991. Epub 2012 May 23. PubMed PMID: 22649570; PubMed Central PMCID: PMC3359346.

 

Vivier E, Ugolini S, Blaise D, Chabannon C, Brossay L. Targeting natural killer cells and natural killer T cells in cancer. Nat Rev Immunol. 2012 Mar 22;12(4):239-52. doi: 10.1038/nri3174. Review. PubMed PMID: 22437937; PubMed Central PMCID: PMC5161343.

 

Case LK, Toussaint L, Moussawi M, Roberts B, Saligrama N, Brossay L, Huber SA, Teuscher C. Chromosome y regulates survival following murine coxsackievirus b3 infection. G3 (Bethesda). 2012 Jan;2(1):115-21. doi: 10.1534/g3.111.001610. Epub 2012 Jan 1. PubMed PMID: 22384388; PubMed Central PMCID: PMC3276194.

 

Schlub TE, Sun JC, Walton SM, Robbins SH, Pinto AK, Munks MW, Hill AB, Brossay L, Oxenius A, Davenport MP. Comparing the kinetics of NK cells, CD4, and CD8 T cells in murine cytomegalovirus infection. J Immunol. 2011 Aug 1;187(3):1385-92. doi: 10.4049/jimmunol.1100416. Epub 2011 Jun 22. PubMed PMID: 21697462; PubMed Central PMCID: PMC3771860.

 

Tessmer MS, Reilly EC, Brossay L. Salivary gland NK cells are phenotypically and functionally unique. PLoS Pathog. 2011 Jan 13;7(1):e1001254. doi: 10.1371/journal.ppat.1001254. PubMed PMID: 21249177; PubMed Central PMCID: PMC3020929.

 

Reilly EC, Wands JR, Brossay L. Cytokine dependent and independent iNKT cell activation. Cytokine. 2010 Sep;51(3):227-31. doi: 10.1016/j.cyto.2010.04.016. Review. PubMed PMID: 20554220; PubMed Central PMCID: PMC2914806.

 

Terrizzi SC, Banh C, Brossay L. A protocol for the production of KLRG1 tetramer. J Vis Exp. 2010 Jan 12;(35). doi: 10.3791/1701. PubMed PMID: 20068548; PubMed Central PMCID: PMC2848686.

 

Banh C, Fugère C, Brossay L. Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling. Blood. 2009 Dec 17;114(26):5299-306. doi: 10.1182/blood-2009-06-228353. Epub 2009 Oct 23. PubMed PMID: 19855082; PubMed Central PMCID: PMC2796135.

 

Nguyen V, Cao L, Lin JT, Hung N, Ritz A, Yu K, Jianu R, Ulin SP, Raphael BJ, Laidlaw DH, Brossay L, Salomon AR. A new approach for quantitative phosphoproteomic dissection of signaling pathways applied to T cell receptor activation. Mol Cell Proteomics. 2009 Nov;8(11):2418-31. doi: 10.1074/mcp.M800307-MCP200. Epub 2009 Jul 14. PubMed PMID: 19605366; PubMed Central PMCID: PMC2773711.

 

Wintermeyer P, Cheng CW, Gehring S, Hoffman BL, Holub M, Brossay L, Gregory SH. Invariant natural killer T cells suppress the neutrophil inflammatory response in a mouse model of cholestatic liver damage. Gastroenterology. 2009 Mar;136(3):1048-59. doi: 10.1053/j.gastro.2008.10.027. Epub 2008 Nov 1. PubMed PMID: 19056387; PubMed Central PMCID: PMC2654188.

 

Tessmer MS, Fatima A, Paget C, Trottein F, Brossay L. NKT cell immune responses to viral infection. Expert Opin Ther Targets. 2009 Feb;13(2):153-62. doi: 10.1517/14712590802653601. Review. PubMed PMID: 19236234; PubMed Central PMCID: PMC2921843.

 

Chaix J, Tessmer MS, Hoebe K, Fuséri N, Ryffel B, Dalod M, Alexopoulou L, Beutler B, Brossay L, Vivier E, Walzer T. Cutting edge: Priming of NK cells by IL-18. J Immunol. 2008 Aug 1;181(3):1627-31. doi: 10.4049/jimmunol.181.3.1627. PubMed PMID: 18641298; PubMed Central PMCID: PMC5154249.

 

Wesley JD, Tessmer MS, Chaukos D, Brossay L. NK cell-like behavior of Valpha14i NK T cells during MCMV infection. PLoS Pathog. 2008 Jul 18;4(7):e1000106. doi: 10.1371/journal.ppat.1000106. PubMed PMID: 18636102; PubMed Central PMCID: PMC2442879.

 

Guia S, Cognet C, de Beaucoudrey L, Tessmer MS, Jouanguy E, Berger C, Filipe-Santos O, Feinberg J, Camcioglu Y, Levy J, Al Jumaah S, Al-Hajjar S, Stephan JL, Fieschi C, Abel L, Brossay L, Casanova JL, Vivier E. A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo. Blood. 2008 May 15;111(10):5008-16. doi: 10.1182/blood-2007-11-122259. Epub 2008 Mar 4. PubMed PMID: 18319400.

 

Pilbeam K, Basse P, Brossay L, Vujanovic N, Gerstein R, Vallejo AN, Borghesi L. The ontogeny and fate of NK cells marked by permanent DNA rearrangements. J Immunol. 2008 Feb 1;180(3):1432-41. doi: 10.4049/jimmunol.180.3.1432. PubMed PMID: 18209038; PubMed Central PMCID: PMC4465768.

 

Wesley JD, Tessmer MS, Paget C, Trottein F, Brossay L. A Y chromosome-linked factor impairs NK T development. J Immunol. 2007 Sep 15;179(6):3480-7. doi: 10.4049/jimmunol.179.6.3480. PubMed PMID: 17785781.

 

Tessmer MS, Fugere C, Stevenaert F, Naidenko OV, Chong HJ, Leclercq G, Brossay L. KLRG1 binds cadherins and preferentially associates with SHIP-1. Int Immunol. 2007 Apr;19(4):391-400. doi: 10.1093/intimm/dxm004. Epub 2007 Feb 16. PubMed PMID: 17307799.

 

Wesley JD, Robbins SH, Sidobre S, Kronenberg M, Terrizzi S, Brossay L. Cutting edge: IFN-gamma signaling to macrophages is required for optimal Valpha14i NK T/NK cell cross-talk. J Immunol. 2005 Apr 1;174(7):3864-8. doi: 10.4049/jimmunol.174.7.3864. PubMed PMID: 15778340.

 

Lawton AP, Prigozy TI, Brossay L, Pei B, Khurana A, Martin D, Zhu T, Späte K, Ozga M, Höning S, Bakke O, Kronenberg M. The mouse CD1d cytoplasmic tail mediates CD1d trafficking and antigen presentation by adaptor protein 3-dependent and -independent mechanisms. J Immunol. 2005 Mar 15;174(6):3179-86. doi: 10.4049/jimmunol.174.6.3179. PubMed PMID: 15749847.

 

Robbins SH, Tessmer MS, Van Kaer L, Brossay L. Direct effects of T-bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation. Eur J Immunol. 2005 Mar;35(3):757-65. doi: 10.1002/eji.200425797. PubMed PMID: 15719366.

 

Anfossi N, Robbins SH, Ugolini S, Georgel P, Hoebe K, Bouneaud C, Ronet C, Kaser A, DiCioccio CB, Tomasello E, Blumberg RS, Beutler B, Reiner SL, Alexopoulou L, Lantz O, Raulet DH, Brossay L, Vivier E. Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules. J Immunol. 2004 Sep 15;173(6):3773-82. doi: 10.4049/jimmunol.173.6.3773. PubMed PMID: 15356124.

 

Robbins SH, Tessmer MS, Mikayama T, Brossay L. Expansion and contraction of the NK cell compartment in response to murine cytomegalovirus infection. J Immunol. 2004 Jul 1;173(1):259-66. doi: 10.4049/jimmunol.173.1.259. PubMed PMID: 15210783.

 

Eash S, Tavares R, Stopa EG, Robbins SH, Brossay L, Atwood WJ. Differential distribution of the JC virus receptor-type sialic acid in normal human tissues. Am J Pathol. 2004 Feb;164(2):419-28. doi: 10.1016/S0002-9440(10)63132-X. PubMed PMID: 14742248; PubMed Central PMCID: PMC1602281.

 

Rhee RJ, Carlton S, Lomas JL, Lane C, Brossay L, Cioffi WG, Ayala A. Inhibition of CD1d activation suppresses septic mortality: a role for NK-T cells in septic immune dysfunction. J Surg Res. 2003 Nov;115(1):74-81. doi: 10.1016/s0022-4804(03)00220-8. PubMed PMID: 14572776.

 

Robbins SH, Terrizzi SC, Sydora BC, Mikayama T, Brossay L. Differential regulation of killer cell lectin-like receptor G1 expression on T cells. J Immunol. 2003 Jun 15;170(12):5876-85. doi: 10.4049/jimmunol.170.12.5876. PubMed PMID: 12794113.

 

Maverakis E, Beech J, Stevens DB, Ametani A, Brossay L, van den Elzen P, Mendoza R, Thai Q, Macias LH, Ethell D, Campagnoni CW, Campagnoni AT, Sette A, Sercarz EE. Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5342-7. doi: 10.1073/pnas.0936151100. Epub 2003 Apr 21. PubMed PMID: 12707414; PubMed Central PMCID: PMC154347.

 

Wesley J, Brossay L. NK T cell-NK cell cross-talk: reciprocal interaction and activation?. Arch Immunol Ther Exp (Warsz). 2003;51(2):121-6. Review. PubMed PMID: 12776911.

 

Robbins SH, Brossay L. NK cell receptors: emerging roles in host defense against infectious agents. Microbes Infect. 2002 Dec;4(15):1523-30. doi: 10.1016/s1286-4579(02)00035-7. Review. PubMed PMID: 12505524.

 

Robbins SH, Nguyen KB, Takahashi N, Mikayama T, Biron CA, Brossay L. Cutting edge: inhibitory functions of the killer cell lectin-like receptor G1 molecule during the activation of mouse NK cells. J Immunol. 2002 Mar 15;168(6):2585-9. doi: 10.4049/jimmunol.168.6.2585. PubMed PMID: 11884419.

 

Biron CA, Brossay L. NK cells and NKT cells in innate defense against viral infections. Curr Opin Immunol. 2001 Aug;13(4):458-64. doi: 10.1016/s0952-7915(00)00241-7. Review. PubMed PMID: 11498302.

 

Kamada N, Iijima H, Kimura K, Harada M, Shimizu E, Motohashi Si, Kawano T, Shinkai H, Nakayama T, Sakai T, Brossay L, Kronenberg M, Taniguchi M. Crucial amino acid residues of mouse CD1d for glycolipid ligand presentation to V(alpha)14 NKT cells. Int Immunol. 2001 Jul;13(7):853-61. doi: 10.1093/intimm/13.7.853. PubMed PMID: 11431415.

 

Prigozy TI, Naidenko O, Qasba P, Elewaut D, Brossay L, Khurana A, Natori T, Koezuka Y, Kulkarni A, Kronenberg M. Glycolipid antigen processing for presentation by CD1d molecules. Science. 2001 Jan 26;291(5504):664-7. doi: 10.1126/science.291.5504.664. PubMed PMID: 11158680.

 

Burdin N, Brossay L, Degano M, Iijima H, Gui M, Wilson IA, Kronenberg M. Structural requirements for antigen presentation by mouse CD1. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10156-61. doi: 10.1073/pnas.97.18.10156. PubMed PMID: 10963678; PubMed Central PMCID: PMC27774.

 

Elewaut D, Brossay L, Santee SM, Naidenko OV, Burdin N, De Winter H, Matsuda J, Ware CF, Cheroutre H, Kronenberg M. Membrane lymphotoxin is required for the development of different subpopulations of NK T cells. J Immunol. 2000 Jul 15;165(2):671-9. doi: 10.4049/jimmunol.165.2.671. PubMed PMID: 10878339.