This NIH project will develop new multiscale biofluid mechanics models and apply them to simulate mouse-specific geometries obtained at Professor Humphrey’s laboratory at Yale University. In particular, we will build on our preliminary work on multiscale simulation of brain aneurysms,
where for the first time we demonstrated the coupling of scales using two different continuum/atomistic parallel codes and the scalability of this approach to tens of thousands of computer processors. The new work is focused mostly on biophysical modeling, including new platelet dynamics and fibrin polymerization models. In addition, we will work closely with
collaborators at Yale University in coupling our fluid codes with their solid mechanics code, hence creating, for the first time, a seamless approach to modeling all important multiscale and multiphysics aspects of thrombus formation, growth, and subsequent remodeling.