Our laboratory investigates how the brain turns thought into voluntary behavior. We seek to expand our understanding of the basic principles of neural computation, and use this knowledge to improve the quality of life of persons with paralysis. We study how populations of neurons represent and transform information as motor plans evolve towards movement execution. This approach has required the creation of novel technology to simultaneously record the activity of hundreds of individual neurons. Our work has led to a clinical trial where humans with paralysis can use neural activity to directly control external devices.