Publications

1.

Interim Safety Profile From the Feasibility Study of the BrainGate Neural Interface System.

Rubin DB, Ajiboye AB, Barefoot L, Bowker M, Cash SS, Chen D, Donoghue JP, Eskandar EN, Friehs G, Grant C, Henderson JM, Kirsch RF, Marujo R, Masood M, Mernoff ST, Miller JP, Mukand JA, Penn RD, Shefner J, Shenoy KV, Simeral JD, Sweet JA, Walter BL, Williams ZM, Hochberg LR.
Neurology. 2023 Mar 14;100(11):e1177-e1192. doi: 10.1212/WNL.0000000000201707. Epub 2023 Jan 13.

PMID: 36639237 Free PMC article. Clinical Trial.
2.

Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training.

Chaudhary U, Vlachos I, Zimmermann JB, Espinosa A, Tonin A, Jaramillo-Gonzalez A, Khalili-Ardali M, Topka H, Lehmberg J, Friehs GM, Woodtli A, Donoghue JP, Birbaumer N.
Nat Commun. 2022 Mar 22;13(1):1236. doi: 10.1038/s41467-022-28859-8.

PMID: 35318316 Free PMC article.
3.

A modified surface EMG biomarker for gait assessment in spastic cerebral palsy.

Vinti M, Saikia MJ, Donoghue J, Mankodiya K, Kerman KL.
Hum Mov Sci. 2021 Dec;80:102875. doi: 10.1016/j.humov.2021.102875. Epub 2021 Nov 1.

PMID: 34736019
4.

Observed Tissue Reactions Associated with Subacute Implantation of Cortical Intraparenchymal Microelectrode Arrays.

Wu C, Sharan AD, Kogan M, Rosenwasser RH, Donoghue J, Serruya MD.
Stereotact Funct Neurosurg. 2021;99(6):526-528. doi: 10.1159/000517249. Epub 2021 Jul 19.

PMID: 34280930 No abstract available.
5.

Selective enhancement of low-gamma activity by tACS improves phonemic processing and reading accuracy in dyslexia.

Marchesotti S, Nicolle J, Merlet I, Arnal LH, Donoghue JP, Giraud AL.
PLoS Biol. 2020 Sep 8;18(9):e3000833. doi: 10.1371/journal.pbio.3000833. eCollection 2020 Sep.

PMID: 32898188 Free PMC article. Clinical Trial.
6.

Neurotechnology-aided interventions for upper limb motor rehabilitation in severe chronic stroke.

Coscia M, Wessel MJ, Chaudary U, Millán JDR, Micera S, Guggisberg A, Vuadens P, Donoghue J, Birbaumer N, Hummel FC.
Brain. 2019 Aug 1;142(8):2182-2197. doi: 10.1093/brain/awz181.

PMID: 31257411 Free PMC article. Review.
7.

Volitional control of single-electrode high gamma local field potentials by people with paralysis.

Milekovic T, Bacher D, Sarma AA, Simeral JD, Saab J, Pandarinath C, Yvert B, Sorice BL, Blabe C, Oakley EM, Tringale KR, Eskandar E, Cash SS, Shenoy KV, Henderson JM, Hochberg LR, Donoghue JP.
J Neurophysiol. 2019 Apr 1;121(4):1428-1450. doi: 10.1152/jn.00131.2018. Epub 2019 Feb 20.

PMID: 30785814 Free PMC article. Clinical Trial.
8.

Watch, Imagine, Attempt: Motor Cortex Single-Unit Activity Reveals Context-Dependent Movement Encoding in Humans With Tetraplegia.

Vargas-Irwin CE, Feldman JM, King B, Simeral JD, Sorice BL, Oakley EM, Cash SS, Eskandar EN, Friehs GM, Hochberg LR, Donoghue JP.
Front Hum Neurosci. 2018 Nov 15;12:450. doi: 10.3389/fnhum.2018.00450. eCollection 2018.

PMID: 30524258 Free PMC article.
9.

Stable long-term BCI-enabled communication in ALS and locked-in syndrome using LFP signals.

Milekovic T, Sarma AA, Bacher D, Simeral JD, Saab J, Pandarinath C, Sorice BL, Blabe C, Oakley EM, Tringale KR, Eskandar E, Cash SS, Henderson JM, Shenoy KV, Donoghue JP, Hochberg LR.
J Neurophysiol. 2018 Jul 1;120(1):343-360. doi: 10.1152/jn.00493.2017. Epub 2018 Apr 25.

PMID: 29694279 Free PMC article. Clinical Trial.
10.

Phase reorganization leads to transient β-LFP spatial wave patterns in motor cortex during steady-state movement preparation.

Rule ME, Vargas-Irwin C, Donoghue JP, Truccolo W.
J Neurophysiol. 2018 Jun 1;119(6):2212-2228. doi: 10.1152/jn.00525.2017. Epub 2018 Feb 14.

PMID: 29442553 Free PMC article.
11.

Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration.

Ajiboye AB, Willett FR, Young DR, Memberg WD, Murphy BA, Miller JP, Walter BL, Sweet JA, Hoyen HA, Keith MW, Peckham PH, Simeral JD, Donoghue JP, Hochberg LR, Kirsch RF.
Lancet. 2017 May 6;389(10081):1821-1830. doi: 10.1016/S0140-6736(17)30601-3. Epub 2017 Mar 28.

PMID: 28363483 Free PMC article. Clinical Trial.
12.

Dissociation between sustained single-neuron spiking and transient β-LFP oscillations in primate motor cortex.

Rule ME, Vargas-Irwin CE, Donoghue JP, Truccolo W.
J Neurophysiol. 2017 Apr 1;117(4):1524-1543. doi: 10.1152/jn.00651.2016. Epub 2017 Jan 18.

PMID: 28100654 Free PMC article.
13.

Scanning electron microscopy of chronically implanted intracortical microelectrode arrays in non-human primates.

Barrese JC, Aceros J, Donoghue JP.
J Neural Eng. 2016 Apr;13(2):026003. doi: 10.1088/1741-2560/13/2/026003. Epub 2016 Jan 29.

PMID: 26824680 Free PMC article.
14.

Virtual typing by people with tetraplegia using a self-calibrating intracortical brain-computer interface.

Jarosiewicz B, Sarma AA, Bacher D, Masse NY, Simeral JD, Sorice B, Oakley EM, Blabe C, Pandarinath C, Gilja V, Cash SS, Eskandar EN, Friehs G, Henderson JM, Shenoy KV, Donoghue JP, Hochberg LR.
Sci Transl Med. 2015 Nov 11;7(313):313ra179. doi: 10.1126/scitranslmed.aac7328.

PMID: 26560357 Free PMC article.
15.

Linking Objects to Actions: Encoding of Target Object and Grasping Strategy in Primate Ventral Premotor Cortex.

Vargas-Irwin CE, Franquemont L, Black MJ, Donoghue JP.
J Neurosci. 2015 Jul 29;35(30):10888-97. doi: 10.1523/JNEUROSCI.1574-15.2015.

PMID: 26224870 Free PMC article.
16.

Contribution of LFP dynamics to single-neuron spiking variability in motor cortex during movement execution.

Rule ME, Vargas-Irwin C, Donoghue JP, Truccolo W.
Front Syst Neurosci. 2015 Jun 22;9:89. doi: 10.3389/fnsys.2015.00089. eCollection 2015.

PMID: 26157365 Free PMC article.
17.

The BRAIN Initiative: developing technology to catalyse neuroscience discovery.

Jorgenson LA, Newsome WT, Anderson DJ, Bargmann CI, Brown EN, Deisseroth K, Donoghue JP, Hudson KL, Ling GS, MacLeish PR, Marder E, Normann RA, Sanes JR, Schnitzer MJ, Sejnowski TJ, Tank DW, Tsien RY, Ugurbil K, Wingfield JC.
Philos Trans R Soc Lond B Biol Sci. 2015 May 19;370(1668):20140164. doi: 10.1098/rstb.2014.0164.

PMID: 25823863 Free PMC article. Review.
18.

Reprint of “Non-causal spike filtering improves decoding of movement intention for intracortical BCIs”.

Masse NY, Jarosiewicz B, Simeral JD, Bacher D, Stavisky SD, Cash SS, Oakley EM, Berhanu E, Eskandar E, Friehs G, Hochberg LR, Donoghue JP.
J Neurosci Methods. 2015 Apr 15;244:94-103. doi: 10.1016/j.jneumeth.2015.02.001. Epub 2015 Feb 11.

PMID: 25681017 Free PMC article.
19.

Spike train SIMilarity Space (SSIMS): a framework for single neuron and ensemble data analysis.

Vargas-Irwin CE, Brandman DM, Zimmermann JB, Donoghue JP, Black MJ.
Neural Comput. 2015 Jan;27(1):1-31. doi: 10.1162/NECO_a_00684.

PMID: 25380335 Free PMC article.
20.

Population interactions between parietal and primary motor cortices during reach.

Menzer DL, Rao NG, Bondy A, Truccolo W, Donoghue JP.
J Neurophysiol. 2014 Dec 1;112(11):2959-84. doi: 10.1152/jn.00851.2012. Epub 2014 Sep 10.

PMID: 25210154 Free PMC article.
21.

Non-causal spike filtering improves decoding of movement intention for intracortical BCIs.

Masse NY, Jarosiewicz B, Simeral JD, Bacher D, Stavisky SD, Cash SS, Oakley EM, Berhanu E, Eskandar E, Friehs G, Hochberg LR, Donoghue JP.
J Neurosci Methods. 2014 Oct 30;236:58-67. doi: 10.1016/j.jneumeth.2014.08.004. Epub 2014 Aug 13.

PMID: 25128256 Free PMC article. Clinical Trial.
22.

Reliability of directional information in unsorted spikes and local field potentials recorded in human motor cortex.

Perge JA, Zhang S, Malik WQ, Homer ML, Cash S, Friehs G, Eskandar EN, Donoghue JP, Hochberg LR.
J Neural Eng. 2014 Aug;11(4):046007. doi: 10.1088/1741-2560/11/4/046007. Epub 2014 Jun 12.

PMID: 24921388 Free PMC article.
23.

Failure mode analysis of silicon-based intracortical microelectrode arrays in non-human primates.

Barrese JC, Rao N, Paroo K, Triebwasser C, Vargas-Irwin C, Franquemont L, Donoghue JP.
J Neural Eng. 2013 Dec;10(6):066014. doi: 10.1088/1741-2560/10/6/066014. Epub 2013 Nov 12.

PMID: 24216311 Free PMC article.
24.

Cue to action processing in motor cortex populations.

Rao NG, Donoghue JP.
J Neurophysiol. 2014 Jan;111(2):441-53. doi: 10.1152/jn.00274.2013. Epub 2013 Oct 30.

PMID: 24174650 Free PMC article.
25.

Sensors and decoding for intracortical brain computer interfaces.

Homer ML, Nurmikko AV, Donoghue JP, Hochberg LR.
Annu Rev Biomed Eng. 2013;15:383-405. doi: 10.1146/annurev-bioeng-071910-124640.

PMID: 23862678 Free PMC article. Review.
26.

Advantages of closed-loop calibration in intracortical brain-computer interfaces for people with tetraplegia.

Jarosiewicz B, Masse NY, Bacher D, Cash SS, Eskandar E, Friehs G, Donoghue JP, Hochberg LR.
J Neural Eng. 2013 Aug;10(4):046012. doi: 10.1088/1741-2560/10/4/046012. Epub 2013 Jul 10.

PMID: 23838067 Free PMC article.
27.

Intra-day signal instabilities affect decoding performance in an intracortical neural interface system.

Perge JA, Homer ML, Malik WQ, Cash S, Eskandar E, Friehs G, Donoghue JP, Hochberg LR.
J Neural Eng. 2013 Jun;10(3):036004. doi: 10.1088/1741-2560/10/3/036004. Epub 2013 Apr 10.

PMID: 23574741 Free PMC article.
28.

Somatosensory responses in a human motor cortex.

Shaikhouni A, Donoghue JP, Hochberg LR.
J Neurophysiol. 2013 Apr;109(8):2192-204. doi: 10.1152/jn.00368.2012. Epub 2013 Jan 23.

PMID: 23343902 Free PMC article. Clinical Trial.
29.

Simultaneous reconstruction of continuous hand movements from primary motor and posterior parietal cortex.

Philip BA, Rao N, Donoghue JP.
Exp Brain Res. 2013 Mar;225(3):361-75. doi: 10.1007/s00221-012-3377-0. Epub 2012 Dec 29.

PMID: 23274645 Free PMC article.
30.

Decoding 3D reach and grasp from hybrid signals in motor and premotor cortices: spikes, multiunit activity, and local field potentials.

Bansal AK, Truccolo W, Vargas-Irwin CE, Donoghue JP.
J Neurophysiol. 2012 Mar;107(5):1337-55. doi: 10.1152/jn.00781.2011. Epub 2011 Dec 7.

PMID: 22157115 Free PMC article.
31.

Point-and-click cursor control with an intracortical neural interface system by humans with tetraplegia.

Kim SP, Simeral JD, Hochberg LR, Donoghue JP, Friehs GM, Black MJ.
IEEE Trans Neural Syst Rehabil Eng. 2011 Apr;19(2):193-203. doi: 10.1109/TNSRE.2011.2107750. Epub 2011 Jan 28.

PMID: 21278024 Free PMC article.
32.

Relationships among low-frequency local field potentials, spiking activity, and three-dimensional reach and grasp kinematics in primary motor and ventral premotor cortices.

Bansal AK, Vargas-Irwin CE, Truccolo W, Donoghue JP.
J Neurophysiol. 2011 Apr;105(4):1603-19. doi: 10.1152/jn.00532.2010. Epub 2011 Jan 27.

PMID: 21273313 Free PMC article.
33.

Decoding complete reach and grasp actions from local primary motor cortex populations.

Vargas-Irwin CE, Shakhnarovich G, Yadollahpour P, Mislow JM, Black MJ, Donoghue JP.
J Neurosci. 2010 Jul 21;30(29):9659-69. doi: 10.1523/JNEUROSCI.5443-09.2010.

PMID: 20660249 Free PMC article.
34.

Decoding 3-D reach and grasp kinematics from high-frequency local field potentials in primate primary motor cortex.

Zhuang J, Truccolo W, Vargas-Irwin C, Donoghue JP.
IEEE Trans Biomed Eng. 2010 Jul;57(7):1774-84. doi: 10.1109/TBME.2010.2047015. Epub 2010 Apr 15.

PMID: 20403782 Free PMC article.
35.

Neurons in primary motor cortex engaged during action observation.

Dushanova J, Donoghue J.
Eur J Neurosci. 2010 Jan;31(2):386-98. doi: 10.1111/j.1460-9568.2009.07067.x. Epub 2010 Jan 13.

PMID: 20074212 Free PMC article.
36.

Listening to Brain Microcircuits for Interfacing With External World-Progress in Wireless Implantable Microelectronic Neuroengineering Devices: Experimental systems are described for electrical recording in the brain using multiple microelectrodes and short range implantable or wearable broadcasting units.

Nurmikko AV, Donoghue JP, Hochberg LR, Patterson WR, Song YK, Bull CW, Borton DA, Laiwalla F, Park S, Ming Y, Aceros J.
Proc IEEE Inst Electr Electron Eng. 2010;98(3):375-388. doi: 10.1109/JPROC.2009.2038949.

PMID: 21654935 Free PMC article.
37.

Collective dynamics in human and monkey sensorimotor cortex: predicting single neuron spikes.

Truccolo W, Hochberg LR, Donoghue JP.
Nat Neurosci. 2010 Jan;13(1):105-11. doi: 10.1038/nn.2455. Epub 2009 Dec 6.

PMID: 19966837 Free PMC article.
38.

Wireless, high-bandwidth recordings from non-human primate motor cortex using a scalable 16-Ch implantable microsystem.

Borton DA, Song YK, Patterson WR, Bull CW, Park S, Laiwalla F, Donoghue JP, Nurmikko AV.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:5531-4. doi: 10.1109/IEMBS.2009.5333189.

PMID: 19964128 Free PMC article.
39.

Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia.

Kim SP, Simeral JD, Hochberg LR, Donoghue JP, Black MJ.
J Neural Eng. 2008 Dec;5(4):455-76. doi: 10.1088/1741-2560/5/4/010. Epub 2008 Nov 18.

PMID: 19015583 Free PMC article.
40.

Bridging the brain to the world: a perspective on neural interface systems.

Donoghue JP.
Neuron. 2008 Nov 6;60(3):511-21. doi: 10.1016/j.neuron.2008.10.037.

PMID: 18995827
41.

Performance differences in visually and internally guided continuous manual tracking movements.

Philip BA, Wu Y, Donoghue JP, Sanes JN.
Exp Brain Res. 2008 Oct;190(4):475-91. doi: 10.1007/s00221-008-1489-3. Epub 2008 Jul 23.

PMID: 18648785 Free PMC article.
42.

Primary motor cortex tuning to intended movement kinematics in humans with tetraplegia.

Truccolo W, Friehs GM, Donoghue JP, Hochberg LR.
J Neurosci. 2008 Jan 30;28(5):1163-78. doi: 10.1523/JNEUROSCI.4415-07.2008.

PMID: 18234894 Free PMC article.
43.

A brain implantable microsystem with hybrid RF/IR telemetry for advanced neuroengineering applications.

Song YK, Patterson WR, Bull CW, Borton DA, Li Y, Nurmikko AV, Simeral JD, Donoghue JP.
Annu Int Conf IEEE Eng Med Biol Soc. 2007;2007:445-8. doi: 10.1109/IEMBS.2007.4352319.

PMID: 18001985
44.

A microscale photovoltaic neurostimulator for fiber optic delivery of functional electrical stimulation.

Song YK, Stein J, Patterson WR, Bull CW, Davitt KM, Serruya MD, Zhang J, Nurmikko AV, Donoghue JP.
J Neural Eng. 2007 Sep;4(3):213-8. doi: 10.1088/1741-2560/4/3/006. Epub 2007 Apr 27.

PMID: 17873423
45.

Automated spike sorting using density grid contour clustering and subtractive waveform decomposition.

Vargas-Irwin C, Donoghue JP.
J Neurosci Methods. 2007 Aug 15;164(1):1-18. doi: 10.1016/j.jneumeth.2007.03.025. Epub 2007 Apr 12.

PMID: 17512603 Free PMC article.
46.

Neuromotor prosthesis development.

Donoghue JP, Hochberg LR, Nurmikko AV, Black MJ, Simeral JD, Friehs G.
Med Health R I. 2007 Jan;90(1):12-5.

PMID: 17487029 No abstract available.
47.

Inferring attentional state and kinematics from motor cortical firing rates.

Wood F, Prabhat, Donoghue J, Black M.
Conf Proc IEEE Eng Med Biol Soc. 2005;2006:149-52. doi: 10.1109/IEMBS.2005.1616364.

PMID: 17282133
48.

Cortically controlled brain-machine interface.

Hatsopoulos N, Mukand J, Polykoff G, Friehs G, Donoghue J.
Conf Proc IEEE Eng Med Biol Soc. 2005;2005:7660-3. doi: 10.1109/IEMBS.2005.1616286.

PMID: 17282055
49.

Assistive technology and robotic control using motor cortex ensemble-based neural interface systems in humans with tetraplegia.

Donoghue JP, Nurmikko A, Black M, Hochberg LR.
J Physiol. 2007 Mar 15;579(Pt 3):603-11. doi: 10.1113/jphysiol.2006.127209. Epub 2007 Feb 1.

PMID: 17272345 Free PMC article. Review.
50.

Decoding movement intent from human premotor cortex neurons for neural prosthetic applications.

Ojakangas CL, Shaikhouni A, Friehs GM, Caplan AH, Serruya MD, Saleh M, Morris DS, Donoghue JP.
J Clin Neurophysiol. 2006 Dec;23(6):577-84. doi: 10.1097/01.wnp.0000233323.87127.14.

PMID: 17143147 Free PMC article.
51.

Horizons in prosthesis development for the restoration of limb function.

Aaron RK, Herr HM, Ciombor DM, Hochberg LR, Donoghue JP, Briant CL, Morgan JR, Ehrlich MG.
J Am Acad Orthop Surg. 2006;14(10 Spec No.):S198-204. doi: 10.5435/00124635-200600001-00043.

PMID: 17003199 Review.
52.

Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor cortex.

Suner S, Fellows MR, Vargas-Irwin C, Nakata GK, Donoghue JP.
IEEE Trans Neural Syst Rehabil Eng. 2005 Dec;13(4):524-41. doi: 10.1109/TNSRE.2005.857687.

PMID: 16425835
53.

Bayesian population decoding of motor cortical activity using a Kalman filter.

Wu W, Gao Y, Bienenstock E, Donoghue JP, Black MJ.
Neural Comput. 2006 Jan;18(1):80-118. doi: 10.1162/089976606774841585.

PMID: 16354382
54.

Development of neuromotor prostheses for humans.

Donoghue JP, Nurmikko A, Friehs G, Black M.
Suppl Clin Neurophysiol. 2004;57:592-606. doi: 10.1016/s1567-424x(09)70399-x.

PMID: 16106661 Review. No abstract available.
55.

Development of a chipscale integrated microelectrode/microelectronic device for brain implantable neuroengineering applications.

Song YK, Patterson WR, Bull CW, Beals J, Hwang N, Deangelis AP, Lay C, McKay JL, Nurmikko AV, Fellows MR, Simeral JD, Donoghue JP, Connors BW.
IEEE Trans Neural Syst Rehabil Eng. 2005 Jun;13(2):220-6. doi: 10.1109/TNSRE.2005.848337.

PMID: 16003903
56.

A microelectrode/microelectronic hybrid device for brain implantable neuroprosthesis applications.

Patterson WR, Song YK, Bull CW, Ozden I, Deangellis AP, Lay C, McKay JL, Nurmikko AV, Donoghue JD, Connors BW.
IEEE Trans Biomed Eng. 2004 Oct;51(10):1845-53. doi: 10.1109/TBME.2004.831521.

PMID: 15490832
57.

Brain-machine and brain-computer interfaces.

Friehs GM, Zerris VA, Ojakangas CL, Fellows MR, Donoghue JP.
Stroke. 2004 Nov;35(11 Suppl 1):2702-5. doi: 10.1161/01.STR.0000143235.93497.03. Epub 2004 Oct 14.

PMID: 15486335 Review.
58.

A point process framework for relating neural spiking activity to spiking history, neural ensemble, and extrinsic covariate effects.

Truccolo W, Eden UT, Fellows MR, Donoghue JP, Brown EN.
J Neurophysiol. 2005 Feb;93(2):1074-89. doi: 10.1152/jn.00697.2004. Epub 2004 Sep 8.

PMID: 15356183
59.

Modeling and decoding motor cortical activity using a switching Kalman filter.

Wu W, Black MJ, Mumford D, Gao Y, Bienenstock E, Donoghue JP.
IEEE Trans Biomed Eng. 2004 Jun;51(6):933-42. doi: 10.1109/TBME.2004.826666.

PMID: 15188861
60.

On the variability of manual spike sorting.

Wood F, Black MJ, Vargas-Irwin C, Fellows M, Donoghue JP.
IEEE Trans Biomed Eng. 2004 Jun;51(6):912-8. doi: 10.1109/TBME.2004.826677.

PMID: 15188858
61.

Robustness of neuroprosthetic decoding algorithms.

Serruya M, Hatsopoulos N, Fellows M, Paninski L, Donoghue J.
Biol Cybern. 2003 Mar;88(3):219-28. doi: 10.1007/s00422-002-0374-6.

PMID: 12647229
62.

Connecting cortex to machines: recent advances in brain interfaces.

Donoghue JP.
Nat Neurosci. 2002 Nov;5 Suppl:1085-8. doi: 10.1038/nn947.

PMID: 12403992 Review.
63.

Instant neural control of a movement signal.

Serruya MD, Hatsopoulos NG, Paninski L, Fellows MR, Donoghue JP.
Nature. 2002 Mar 14;416(6877):141-2. doi: 10.1038/416141a.

PMID: 11894084