401-863-1303 optimalbup@brown.edu

A Brown University

Research Study

The main goal of the study is to learn if a higher daily dose of buprenorphine compared to a standard dose of buprenorphine…

…better controls symptoms

…improves treatment engagement

…reduces the risk of an overdose

Who can participate?

What are the eligibility requirements?


  • English speaking
  • 18 years or older
  • Diagnosed with moderate to severe opioid use disorder (OUD)
  • Initiating or continuing ≤16mg buprenorphine for treatment of OUD
  • Have a history of fentanyl use
  • Reside in Rhode Island
  • Able to provide informed consent
What would exclude me?


  • Currently pregnant or breastfeeding
  • Currently a prisoner or in police custody

Why is this important?


Reduce Overdoses

The illicit drug supply has changed. Fentanyl and fentanyl analogs have largely replaced heroin, heightening risk for fatal overdose.


Standardize Dosing

Fentanyl’s dominance in the drug supply has changed the therapeutic dose of treatment. The updated optimal buprenorphine dosing is still unknown.


Improve Lives

This study explores the impact of a standard or high dose of buprenorphine maintenance on treatment outcomes in patients with a history of fentanyl use.

Are you a patient of a participating clinic and interested in joining the study?

Sponsors + Partners

Principal Investigator(s): Francesca Beaudoin, MD, PhD & Rachel Wightman, MD
Contact: francesca_beaudoin@brown.edu; rachelwightman@brown.edu
Brown University IRB Protocol # 2022003300