The hyphal-specific toxin candidalysin promotes fungal gut commensalism.
Liang SH, Sircaik S, Dainis J, Kakade P, Penumutchu S, McDonough LD, Chen YH, Frazer C, Schille TB, Allert S, Elshafee O, Hänel M, Mogavero S, Vaishnava S, Cadwell K, Belenky P, Perez JC, Hube B, Ene IV, Bennett RJ. Nature. 2024 Mar;627(8004):620-627. doi: 10.1038/s41586-024-07142-4. Epub 2024 Mar 6. PMID: 38448595.
Fiber supplementation protects from antibiotic-induced gut microbiome dysbiosis by modulating gut redox potential
Penumutchu S, Korry BJ, Hewlett K, Belenky P. Nat Commun. 2023 Aug 24;14(1):5161. doi: 10.1038/s41467-023-40553-x. PMID: 37620319; PMCID: PMC10449846.
Short-Term Dietary Intervention with Whole Oats Protects from Antibiotic-Induced Dysbiosis
Costa SK, Antosca K, Beekman CN, Peterson RL, Penumutchu S, Belenky P. Microbiol Spectr. 2023 Aug 17;11(4):e0237623. doi: 10.1128/spectrum.02376-23. Epub 2023 Jul 13. PMID: 37439681; PMCID: PMC10434222.
Ajibola O, Penumutchu S, Gulumbe B, Aminu U, Belenky P. Longitudinal analysis of the impacts of Urogenital Schistosomiasis on the gut microbiota of adolescents in Nigeria. Scientific Reports. 2023 April 27. https://doi.org/10.21203/rs.3.rs-2832346/v1. under review.
Korry BJ and Belenky P. Trophic level and proteobacteria abundance drive antibiotic resistance levels in fish from coastal New England. Animal Microbiome. 2023 March 6; 5(1). https://doi.org/10.1186/s42523-023-00236-w.
McDonough LD, Mishra AA, Tosini N, Kakade P, Penumutchu S, Liang SH, Maufrais C, Zhai B, Taur T, Belenky P, Bennett RJ, Hohl TM, Koh AY, Ene IV. C Candida albicans isolates 529L and CHN1 exhibit stable colonization of the murine gastrointestinal tract. mBio. 2021 Dec 21;12(6):e0287821. doi: 10.1128/mBio.02878-21.
Streptozotocin-Induced Hyperclycemia Alters the Cecal Metabolome and Exacerbates Antibiotic-Induced Dysbiosis
Wurster JI, Peterson RL, Brown CE, Penumutchu S, Guzior DV, Neugebauer K, Sano WH, Sebastian MM, Quinn RA, Belenky P. Cell Rep. 2021, Dec 14;37(11):110113. doi: 10.1016/j.celrep.2021.110113
Genotoxic Agents Produce Stressor-Specific Spectra of Spectinomycin Resistance Mutations Based on Mechanism of Action and Selection in Bacillus subtilis.
Korry BJ, Lee SYE, Chakrabati AK, Choi AH, Ganser C, Machan JT, Belenky P. Antimicrob Agents Chemother. 2021, Sep 17;65(10):e0089121. doi: 10.1128/AAC.00891-21
Diamond E, Hewlett K, Penumutchu S, Belenky A, Belenky P. Coffee consumption modulates amoxicillin-induced dysbiosis in the murine gut microbiome. Front Microbiol. 2021, 12:637282.
Evaluation of the Microbiome in Men Taking Pre-exposure Prophylaxis for HIV Prevention
Perler BK, Reinhart EM, Montgomery M, Maynard M, Shapiro JM, Belenky P, Chan PA. AIDS Behav. 2021 Jan 4. doi:10.1007/s10461-020-03130-7. Epub ahead of print.
Comsumption of a Western-Style Diet Modulates the Response of the Murine Gut Microbiome to Ciprofloxacin
Cabral DJ, Wurster JI, Korry BJ, Penumutchu S, Belenky P. mSystems. 2020, 5(4), e00317-20. doi:10.1128/mSystems.00317-20
Oxygen and Metabolism: Digesting Determinants of Antibiotic Susceptibility in the Gut
Heinzinger LR, Johnson A, Wurster JI, Nilson R, Penumutchu S, Belenky P. iScience. 2020;23(12):101875. doi: 10.1016/j.isci.2020.101875.
Liu RT, Rowan-Nash AD, Sheehan AE, Walsh RFL, Sanzari CM, Korry BK, Belenky P. Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults [published online ahead of print, 2020 Mar 27]. Brain Behav Immun. 2020;S0889-1591(19)31531-4. doi:10.1016/j.bbi.2020.03.026
Korry BJ, Cabral DJ, Belenky P. Metatranscriptomics Reveals Antibiotic-Induced Resistance Gene Expression in the Murine Gut Microbiota. Front Microbiol. 2020;11:322. Published 2020 Mar 6. doi:10.3389/fmicb.2020.00322
Antimicrobial Resistance Gene Prevalence in a Population of Patients with Advanced Dementia is Related to Specific Pathobionts
Rowan-Nash AD, Araos R, D’Agata EMC, Belenky P. iScience. 2020, 23(3), 100905.
Filling a hole in ozone research: The impacts of early life microbiome alterations on pulmonary responses to a non-atopic asthma trigger
Johnston RA, Belenky P. Physiological Reports. 2020, 8(1), e14346.
Microbial metabolism modulates antibiotic susceptibility within the murine gut microbiome
Cabral DJ, Penumutchu S, Reinhart EM, Zhang C, Korry BJ, Wurster JI, Nilson R, Guang A, Sano WH, Rowan-Nash AD, Li H, Belenky P. Cell Metabolism. 2019, 30(4), 800-23.
Defining the Distinct Skin and Gut Microbiomes of the Northern Pike (Esox lucius)
Reinhart EM, Korry, BJ, Rowan-Nash AD, Peter Belenky. Frontiers in Microbiology. 2019, 10, 2118.
Ajibola O, Rowan AD, Ogedengbe CO, Mshelia MB, Cabral DJ, Eze AA, Obaro S, Belenky P. Urogenital Schistosomiasis is associated with signatures of microbiome dysbiosis in Nigerian adolescents. Scientific Reports. 2019, 9(1), 829.
Lee KM, Morris-Love J, Cabral DJ, Belenky P., Opal SM, Jamieson AM. Coinfection With Influenza A Virus and Klebsiella oxytoca: An Underrecognized Impact on Host Resistance and Tolerance to Pulmonary Infections. Front Immunol. 2018, 9, 2377.
Metabolism-induced oxidative stress and DNA damage selectively trigger genome instability in polyploid fungal cells
Thomson GJ, Hernon C, Austriaco N, Shapiro RS, Belenky P, Bennett RJ. EMBO J. 2019, 38(19), e101597.
The Impact of Vegan Production on the Kimchi Microbiome
Zabat M., Sano W.H., Cabral D.J., Wurster J.I., Belenky P. Food Microbiology. 2018, 74, 171-178.
Cross-Domain and Viral Interactions in the Microbiome
Aislinn D. Rowan-Nash, Benjamin J. Korry, Eleftherios Mylonakis, Peter Belenky. Mol. Biol. Rev. 2019, 83 (1) e00044-18.
Cabral DJ, Penumutch S, Norris C, Morones-Ramirez JR, Belenky P. Microbial competition between Escherichia coli and Candida albicans reveals a soluble fungicidal factor. Microbial Cell. 2018, 5(5), 249-255.
Carmona-Gutierrez et al. Guidelines and recommendations on yeast cell death nomenclature. Microbial Cell. 2018, 2018 5 (1), 4-31.
Bactericidal antibiotics induce toxic metabolic perturbations that lead to cellular damage
Belenky P., Ye J.D., Porter C.B.M., Cohen N.R., Lobritz M.A., Ferrante T., Jain S., Korry B.J., Schwarz E.G., Walker G.C. and Collins J.J. Cell Reports. 2015, 13, 968-980.
Bactericidal antibiotics induce programmed metabolic toxicity
Rowan A.D., Cabral D.J., Belenky P. Microbial Cell. 2016, 3(4), 178.
Cabral D.J., Wurster J.I., Flokas M.E., Alevizakos M., Zabat M., Korry B.J., Rowan A.D., Sano W.H., Andreatos N., Ducharme R.B., Chan P.A., Mylonakis E., Fuchs B.B., Belenky P. The salivary microbiome is consistent between subjects and resistant to impacts of short-term hospitalization. Scientific Reports. 2017, 7, 11040.
Meylan S., Porter C.B., Yang J.H., Belenky P., Gutierrez A., Lobritz M.A., Park J., Kim S.H., Moskowitz S.M., Collins J.J. Carbon Sources Tune Antibiotic Susceptibility in Pseudomonas aeruginsoa via Tricarboxylic Acid Cycle Control. Cell Chemical Biology. 2017, 24(2), 195-206.
Cohen N.R., Ross C.A., Jain S., Shapiro R.S., Gutierrez A., Belenky P., Li H. and Collins J.J. A role for the bacterial GATC methylome in antibiotic stress survival. Nature Genetics. 2016, 48(5), 581-586.
Antibiotics induce redox-related physiological alterations as part of their lethality
Dwyer1 D. J. *, Belenky P.*, Yang J. H. *, MacDonald1 C. I., Martell J. D., Chan C. T., Kobayashi N., Lobritz M. A., Braff E., Schwarz E. G., Ye J. D., Patti M., Vercruysse M., Ralifo P. S., Cameron D. E., Allison K. R., Khalil A. S., Ting A. Y., Walker G. C., Collins J. J. PNAS. 2014, 111, E2100-E2109.
Antibiotic efficacy is linked to bacterial cellular respiration
Lobritz M. A.*, Belenky P.*, Porter C. B. M., Gutierrez A., Yang J. H., Schwarz E. G., Dwyer D. J., Khalil A. S., Collins J. J., PNAS. 2014, 112(27), 8173-8180.
Nrt1 and Tna1-Independent export of NAD+ precursor of vitamins promotes NAD+ homeostasis and allows engineering of vitamin production
Belenky P., Stebbins R., Bogan K.L., Charles E.R., & Brenner C. PLoS ONE. 2011, (6), e19710.
Antioxidant Strategies to Tolerate Antibiotics
Belenky P. & Collins J.J. Science. 2011, 334, 915-916.
Belenky P., Camacho D., & Collins J. J., Fungicidal drugs induce a common oxidative damage cellular death pathway. Cell Reports. 2013, 3, 350-358.
Brenner C., Belenky P., Bogan K.L. Yeast strain and method for using the same to produce nicotinamide riboside. US Patent. 2012, 8, 114, 626.
Belenky P., Christensen K.C., Gazzaniga F., Pletnev A.A. & Brenner C. Nicotinamide Riboside and Nicotinic Acid Riboside Salvage in Fungi and Mammals: Quantitative Basis for Urh1 and Purine Nucleoside Phosphorylase Function in NAD+ Metabolism. JBC. 2009, 284, 158-164.
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+
Belenky P., Racette, F.G., Bogan, K.L., McClure, J.M., Smith, J.S. and Brenner, C. Cell. 129, 473-484.
Additional Mentions – Previewed in Cell: 2007 May 4;129(3):453-4. Research Highlights in Nature: Nature 2007 May 10:447:118-119. Spotlight in ACS Chemical Biology: 2007 ACS Chemical Biology, 2(6):363
NAD+ Metabolism in Health and Disease
Belenky P., Bogan, K.L. and Brenner, C. Trends in Biochemical Sciences. 2007, 32, 12-19.
S. cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1
Belenky P., Mogu T.G. and Brenner C. JBC. 2008, 283, 8075-8079.
Tempel W., Rabeh W.M., Bogan K.L., Belenky P., Wojcik M., Seidle H.F., Nedyalkova L., Yang T., Sauve A.A., Park H.-W. and Brenner C. Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biology. 2007, 5(10), e263.
McLean J.E., Hamaguchi N., Belenky P., Mortimer S.E., Stanton M., Hedstrom L. Inosine 5′-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo. Biochemical Journal. 2004, 379, 243-251.