Publications

Comsumption of a Western-Style Diet Modulates the Response of the Murine Gut Microbiome to Ciprofloxacin

Cabral DJ, Wurster JI, Korry BJ, Penumutchu S, Belenky P. mSystems. 2020, 5(4), e00317-20. doi:10.1128/mSystems.00317-20

Liu RT, Rowan-Nash AD, Sheehan AE, Walsh RFL, Sanzari CM, Korry BK, Belenky P. Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults [published online ahead of print, 2020 Mar 27]. Brain Behav Immun. 2020;S0889-1591(19)31531-4. doi:10.1016/j.bbi.2020.03.026

Korry BJ, Cabral DJ, Belenky P. Metatranscriptomics Reveals Antibiotic-Induced Resistance Gene Expression in the Murine Gut Microbiota. Front Microbiol. 2020;11:322. Published 2020 Mar 6. doi:10.3389/fmicb.2020.00322

Antimicrobial Resistance Gene Prevalence in a Population of Patients with Advanced Dementia is Related to Specific Pathobionts

Rowan-Nash AD, Araos R, D’Agata EMC,  Belenky P. iScience. 2020, 23(3), 100905.

Filling a hole in ozone research: The impacts of early life microbiome alterations on pulmonary responses to a non-atopic asthma trigger

Johnston RA, Belenky P. Physiological Reports. 2020, 8(1), e14346.

Microbial metabolism modulates antibiotic susceptibility within the murine gut microbiome

Cabral DJ, Penumutchu S, Reinhart EM, Zhang C, Korry BJ, Wurster JI, Nilson R, Guang A, Sano WH, Rowan-Nash AD, Li H, Belenky P. Cell Metabolism. 2019, 30(4), 800-23.

Defining the Distinct Skin and Gut Microbiomes of the Northern Pike (Esox lucius)

Reinhart EM, Korry, BJ, Rowan-Nash AD, Peter Belenky. Frontiers in Microbiology. 2019, 10, 2118.

Ajibola O, Rowan AD, Ogedengbe CO, Mshelia MB, Cabral DJ, Eze AA, Obaro S, Belenky P. Urogenital Schistosomiasis is associated with signatures of microbiome dysbiosis in Nigerian adolescents. Scientific Reports. 2019, 9(1), 829.

Lee KM, Morris-Love J, Cabral DJ, Belenky P., Opal SM, Jamieson AM. Coinfection With Influenza A Virus and Klebsiella oxytoca: An Underrecognized Impact on Host Resistance and Tolerance to Pulmonary Infections. Front Immunol. 2018, 9, 2377.

Cabral D.J., Wurster J.I., Belenky P. Antibiotic Persistence as a Metabolic Adaptation: Stress, Metabolism, the Host, and New Directions. Pharmaceuticals. 2018, 11(14).

Metabolism-induced oxidative stress and DNA damage selectively trigger genome instability in polyploid fungal cells

Thomson GJ, Hernon C, Austriaco N, Shapiro RS, Belenky P, Bennett RJEMBO J.  2019, 38(19), e101597.

The Impact of Vegan Production on the Kimchi Microbiome

Zabat M., Sano W.H., Cabral D.J., Wurster J.I., Belenky P. Food Microbiology. 2018, 74, 171-178.

Cross-Domain and Viral Interactions in the Microbiome

Aislinn D. Rowan-Nash, Benjamin J. Korry, Eleftherios Mylonakis, Peter Belenky. Mol. Biol. Rev. 2019, 83 (1) e00044-18.

Cabral DJ, Penumutch S, Norris C, Morones-Ramirez JR, Belenky P. Microbial competition between Escherichia coli and Candida albicans reveals a soluble fungicidal factor. Microbial Cell. 2018, 5(5), 249-255.

Carmona-Gutierrez et al. Guidelines and recommendations on yeast cell death nomenclature. Microbial Cell. 2018, 2018 (1), 4-31.

Zabat, M., Sano, W., Wurster, J.I., Cabral D.J., Belenky P. Microbial community analysis of sauerkraut fermentation reveals a stable and rapidly established community. Foods. 2018, 7(5), 77.

Bactericidal antibiotics induce toxic metabolic perturbations that lead to cellular damage

Belenky P., Ye J.D., Porter C.B.M., Cohen N.R., Lobritz M.A., Ferrante T., Jain S., Korry B.J., Schwarz E.G., Walker G.C. and Collins J.J. Cell Reports. 2015, 13, 968-980.

Bactericidal antibiotics induce programmed metabolic toxicity

Rowan A.D., Cabral D.J., Belenky P. Microbial Cell. 2016, 3(4), 178.

Cabral D.J., Wurster J.I., Flokas M.E., Alevizakos M., Zabat M., Korry B.J., Rowan A.D., Sano W.H., Andreatos N., Ducharme R.B., Chan P.A., Mylonakis E., Fuchs B.B., Belenky P. The salivary microbiome is consistent between subjects and resistant to impacts of short-term hospitalization. Scientific Reports. 2017, 7, 11040.

Meylan S., Porter C.B., Yang J.H., Belenky P., Gutierrez A., Lobritz M.A., Park J., Kim S.H., Moskowitz S.M., Collins J.J. Carbon Sources Tune Antibiotic Susceptibility in Pseudomonas aeruginsoa via Tricarboxylic Acid Cycle Control. Cell Chemical Biology2017, 24(2), 195-206.

Cohen N.R., Ross C.A., Jain S., Shapiro R.S., Gutierrez A., Belenky P., Li H. and Collins J.J. A role for the bacterial GATC methylome in antibiotic stress survival. Nature Genetics. 2016, 48(5), 581-586.

Antibiotics induce redox-related physiological alterations as part of their lethality 

Dwyer1 D. J. *, Belenky P.*, Yang J. H. *, MacDonald1 C. I., Martell J. D., Chan C. T., Kobayashi N., Lobritz M. A., Braff E., Schwarz E. G., Ye J. D., Patti M., Vercruysse M., Ralifo P. S., Cameron D. E., Allison K. R., Khalil A. S., Ting A. Y., Walker G. C., Collins J. J. PNAS. 2014, 111, E2100-E2109.

Antibiotic efficacy is linked to bacterial cellular respiration

Lobritz M. A.*Belenky P.*, Porter C. B. M., Gutierrez A., Yang J. H., Schwarz E. G., Dwyer D. J., Khalil A. S., Collins J. J.,  PNAS. 2014, 112(27), 8173-8180.

Nrt1 and Tna1-Independent export of NAD+ precursor of vitamins promotes NAD+ homeostasis and allows engineering of vitamin production

Belenky P., Stebbins R., Bogan K.L., Charles E.R., & Brenner C. PLoS ONE. 2011, (6), e19710.

Antioxidant Strategies to Tolerate Antibiotics

Belenky P. & Collins J.J. Science. 2011, 334, 915-916.

Belenky P., Camacho D., & Collins J. J., Fungicidal drugs induce a common oxidative damage cellular death pathway. Cell Reports. 2013, 3, 350-358. 

Brenner C., Belenky P., Bogan K.L. Yeast strain and method for using the same to produce nicotinamide riboside. US Patent. 2012, 8, 114, 626.

Belenky P., Christensen K.C., Gazzaniga F., Pletnev A.A. & Brenner C. Nicotinamide Riboside and Nicotinic Acid Riboside Salvage in Fungi and Mammals: Quantitative Basis for Urh1 and Purine Nucleoside Phosphorylase Function in NAD+ Metabolism. JBC. 2009, 284, 158-164.

Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+

Belenky P., Racette, F.G., Bogan, K.L., McClure, J.M., Smith, J.S. and Brenner, C. Cell. 129, 473-484.

Additional Mentions – Previewed in Cell: 2007 May 4;129(3):453-4. Research Highlights in NatureNature 2007 May 10:447:118-119. Spotlight in ACS Chemical Biology: 2007 ACS Chemical Biology, 2(6):363

NAD+ Metabolism in Health and Disease

Belenky P., Bogan, K.L. and Brenner, C. Trends in Biochemical Sciences. 2007, 32, 12-19.

S. cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1

Belenky P., Mogu T.G. and Brenner C. JBC. 2008, 283, 8075-8079.

Tempel W., Rabeh W.M., Bogan K.L., Belenky P., Wojcik M., Seidle H.F., Nedyalkova L., Yang T., Sauve A.A., Park H.-W. and Brenner C. Nicotinamide riboside kinase structures reveal new pathways to NAD+PLoS Biology. 2007, 5(10), e263.

McLean J.E., Hamaguchi N., Belenky P., Mortimer S.E., Stanton M., Hedstrom L. Inosine 5′-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo. Biochemical Journal. 2004, 379, 243-251.