Recent Publications

A perspective on neuroscience data standardization with Neurodata Without Borders. Andrea Pierre, Tuan Pham, Jonah Pearl, Sandeep Robert Datta, Jason T. Ritt, Alexander Fleischmann. ArXiv [Preprint]. 2024 Jan 22:arXiv:2310.04317v2. PMID: 37873012; PMCID: PMC10593085. 

Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice. Elizaveta V Bashkirova, Nell Klimpert, Kevin Monahan, Christine E Campbell, Jason Osinski, Longzhi Tan, Ira Schieren, Ariel Pourmorady, Beka Stecky, Gilad Barnea, Xiaoliang Sunney Xie, Ishmail Abdus-Saboor, Benjamin M Shykind, Bianca J Marlin, Richard M Gronostajski, Alexander Fleischmann, Stavros Lomvardas. Elife.  2023 December 18; 12:RP87445 doi: https://doi.org/10.7554/eLife.87445.3

Effects of stochastic coding on olfactory discrimination in flies and mice. Shyam Srinivasan,Simon Daste, Mehrab N. Modi, Glenn C. Turner, Alexander Fleischmann, Saket Navlakha. PLOS Biology 2023 October 31; 21(10): e3002206. https://doi.org/10.1371/journal.pbio.3002206

Differential encoding of odor and place in mouse piriform and entorhinal cortex. Wilson Mena, Keeley Baker, Alon Rubin, Shaun Kohli, Yun Yoo, Yaniv Ziv, Charles Razaei-Mazinani, Alexander Fleischmann.

Mammalian olfactory cortex neurons retain molecular signatures of ancestral cell types. Sara Zeppilli, Alonso Ortega Gurrola, Pinar Demetci, David Brann, Robin Attey, Noga Zilkha, Tali Kimchi, Sandeep Robert Datta, Ritambhara Singh, Maria A. Tosches, Anton Crombach, Alexander Fleischmann. bioRxiv 2023.08.13.553130; doi: https://doi.org/10.1101/2023.08.13.553130

Cerebrospinal fluid transcripts may preduct shunt surgery responses in normal pressure hydrocephalus. Zachary Levin, Owen P Leary, Victor Mora, Shawn Kant, Sarah Brown, KonstantinaSvokos, Umer Akbar, Thomas Serre, Petra Klinge, Alexander Fleischmann, Maria Grazia Ruocco. Brain. 2023 May 19; Volume 146, Issue 9, Pages 3747-3759, ttps://doi.org/10.1093/brain/awad109

Molecular characterization of projection neuron subtypes in the mouse olfactory bulb. Sara Zeppilli, Tobias Ackels, Robin Attey, Nell Klimpert, Kimberly D. Ritola, Stefan Boeing, Anton Crombach, Andreas T. Schaefer, Alexander Fleischmann. Elife. 2021 July 22;10:e65445 doi: 10.7554/eLife.65445

Low signaling efficiency from receptor to effector in olfactory transduction: A quantified ligand-triggered GPCR pathway. Rong-Chang Li, Laurrie L. Molday, Chih-Chun Lin, Xiaozhi Ren, Alexander Fleischmann, Robert S Molday, King-Wai Yau. PNAS Neuroscience. 2022 August 1; 119 (32) e2121225119. doi: https://doi.org/10.1073/pnas.2121225119

Heat But Not Mechanical Hypersensitivity Depends on Voltage-Gated Ca V 2.2 Calcium Channel Activity in Peripheral Axon Terminals Innervating Skin. Daniel M DuBreuil, Eduardo Javier Lopez Soto, Simon Daste, Remy Meir, Daniel Li, Brian Wainger, Alexander Fleischmann, Diane Lipscombe. J Neurosci. 2021 Sep 8;41(36):7546-7560. doi: 10.1523/JNEUROSCI.0195-21.2021

Encoding of Odor Fear Memories in the Mouse Olfactory Cortex. Meissner-Bernard C, Dembitskaya Y, Venance L, Fleischmann A. Current Biology. 2019 Feb 4;29(3):367-380.e4. doi: 10.1016/j.cub.2018.12.003.

Odor identity coding by distributed ensembles of neurons in the mouse olfactory cortex. Roland B, Deneux T, Franks KM, Bathellier B, Fleischmann A. Elife. 2017 May 10;6. pii: e26337. doi: 10.7554/eLife.26337.

Molecular signatures of neural connectivity in the olfactory cortex. Diodato A, Ruinart de Brimont M, Yim YS, Derian N, Perrin S, Pouch J, Klatzmann D, Garel S, Choi GB, Fleischmann A. Nature Communications. 2016 Jul 18;7:12238. doi: 10.1038/ncomms12238.

Massive normalization of olfactory bulb output in mice with a ‘monoclonal nose’. Roland B, Jordan R, Sosulski DL, Diodato A, Fukunaga I, Wickersham I, Franks KM, Schaefer AT, Fleischmann A. Elife. 2016 May 13;5. pii: e16335. doi: 10.7554/eLife.16335.

An Expression Refinement Process Ensures Singular Odorant Receptor Gene Choice. Abdus-Saboor I, Al Nufal MJ, Agha MV, Ruinart de Brimont M, Fleischmann A, Shykind BM. Current Biology. 2016 Apr 25;26(8):1083-90. doi: 10.1016/j.cub.2016.02.039.

Setting limits: maintaining order in a large gene family. Abdus-Saboor I, Fleischmann A, Shykind B. Transcription. 2014;5(3):e28978. doi: 10.4161/trns.28978.

Functional Interrogation of an Odorant Receptor Locus Reveals Multiple Axes of Transcriptional Regulation. Fleischmann A, Abdus-Saboor I, Sayed A, Shykind B. PLoS Biology. 2013 May; 11(5): e1001568. doi: 10.1371/journal.pbio.1001568.

A biophysical signature of network affiliation and sensory processing in mitral cells. Angelo K, Rancz EA, Pimentel D, Hundahl C, Hannibal J, Fleischmann A, Pichler B, Margrie TW. Nature. 2012 Aug 16;488(7411):375-8. doi: 10.1038/nature11291.

Olfactory deficits cause anxiety-like behaviors in mice. Glinka ME, Samuels BA, Diodato A, Teillon J, Feng Mei D, Shykind BM, Hen R, Fleischmann A. Journal of Neuroscience. 2012 May 9;32(19):6718-25. doi: 10.1523/JNEUROSCI.4287-11.2012.

Driving opposing behaviors with ensembles of piriform neurons. Choi GB, Stettler DD, Kallman BR, Bhaskar ST, Fleischmann A, Axel R. Cell. 2011 Sep 16;146(6):1004-15. doi: 10.1016/j.cell.2011.07.041.

Mice with a “monoclonal nose”: perturbations in an olfactory map impair odor discrimination. Fleischmann A, Shykind BM, Sosulski DL, Franks KM, Glinka ME, Mei DF, Sun Y, Kirkland J, Mendelsohn M, Albers MW, Axel R. Neuron. 2008 Dec 26;60(6):1068-81. doi: 10.1016/j.neuron.2008.10.046.