“Using Deep RNA Sequencing to Assess Antibody Response to Infection.”
Current clinical practices rely on physiological scoring systems to assess severity of illness and therapeutic responses. This application focuses on monitoring the immune response in ICU patients that lead to complications such as immunosuppression and subsequent infections, and resultantly life threatening scenarios. Here we propose to use deep RNA sequencing as a means to characterize the mechanisms of morbidity in ICU patients. In addition, we propose a new avenue for the development of diagnostic and therapeutic tools to allow clinicians to more effectively treat critically ill patients.
This study supported by COBRE Phase II PAR-23-063