From Independent Research

  • 217. Roy, B.; Kojima, R.; Shah, O.; Shieh, M.; Das, E.; Ezzatpour, S.; Sato, E.; Hirata, Y.; Lindahl, S.; Matsuzawa, A.; Aguilar, H. C.; Xian, M. Generation of Thiyl Radicals in a Spatiotemporal Controlled Manner by Light: Applied for the Cis to Trans Isomerization of Unsaturated Fatty Acids/Phospholipids. Redox Biol. 2024, in press.
  • 216. Shieh, M.; Chung, A. Y.; Lindahl, S.; Veliz, M.; Bain, C. A.; Xian, M. Understanding Polysulfide-Mediated Papain Inhibition and Differentiating between Disulfide vs Persulfide Formation. ACS Chem. Biol. 2024, in press.
  • 215. Roy, B.; Shieh, M.; Takata, T.; Jung, M.; Das, E.; Xu, S.; Akaike, T.; Xian, M. Photo-Triggered Hydrogen Persulfide Donors via Hydrosulfide Radical Formation-Enhancing the Reactive Sulfur Metabolome in Cells. J. Am. Chem. Soc., 2024, 146, 30502-30509.
  • 214. Li, X.; Toyomoto, T.; Zhang, T.; Guo, C.; Lindahl, S.; Tsutsuki, H.; Xian, M.; Sawa, T. Supersulfides suppress type-I and type-II interferon response by blocking JAK/STAT signaling in macrophages. Int. Immunol. 2024, 36, 641-652.
  • 213. Noor, Z.; Ni, X.; Xian, M. In-situ generation of hydrogen polysulfides (H2Sn) with thioglucose, glucose oxidase, and chloroperoxidase. ChemBioChem 2024, 25, e202400390.
  • 212. Olson, K. R.; Clear, K. J.; Takata, T.; Gao, Y.; Ma, Z.; Pfaff, E.; Travlos, A.; Luu, J.; Wilson, K.; Joseph, Z.; Kyle, I.; Kasko, S. M.; Jones, Jr., P.; Fukuto, J.; Xian, M.; Wu, G.; Straub, K. D. Reaction mechanisms of H2S oxidation by naphthoquinones. Antioxidants 2024, 13, 619.
  • 211. Xu, S.; Ramush, G.; Yang, I. J.; Das, E.; Shieh, M.; Xian, M. Geminal-dithiol based precursors for reactive sulfur species. Chem. Commun. 2024, 60, 5606.
  • 210. Cui, Q.; Shieh, M.; Pan, T. W.; Nishimura, A.; Matsunaga, T.; Kelly, S. S.; Xu, S.; Jung, M.; Ogata, S.; Morita, M.; Yoshitake, J.; Chen, X.; Robinson, J. R.; Qian, W. J.; Nishida, M.; Akaike, T.; Xian, M. 2H-Thiopyran-2-thione sulfine, a compound for converting H2S to HSOH/H2S2 and increasing intracellular sulfane sulfur levels. Nat. Commun. 2024, 15, 2453.
  • 209. Lindahl, S.; Shieh, M.; Zhang, T.; Guo, C.; Robinson, J. R.; Sawa, T.; Xian, M. Thioglucose-derived tetrasulfide, a unique polysulfide model compound. Redox Biol. 2024, 70, 103045.
  • 208. Hirai, T.; Ikeda-Imafuku, M.; Tasaka, N.; Chuang, V. T. G.; Xian, M.; Ishida, T.; Akaike, T.; Ishima, Y. Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides. Adv. Redox Res. 2024, 10, 100091.
  • 207. Ni, X.; Marutani, E.; Shieh, M.; Lam, Y.; Ichinose, F.; Xian, M. Selenium-based catalytic scavengers for concurrent scavenging of H2S and reactive oxygen species. Angew. Chem. Int. Ed. 2024, 63, e202317487.
  • 206. Bai, J.; Jiao, F.; Salmeron, A. G.; Xu, S.; Xian, M.; Huang, L.; Chen, D. B. Mapping pregnancy-dependent sulfhydrome unfolds diverse functions of protein sulfhydration in human uterine artery. Endocrinology, 2023, 164, bqad107.
  • 205. Xu, S.; Shieh, M.; Paul, B. D.; Xian, M. Hydrogen sulfide: recent development of its dual donors and hybrid drugs. Br. J. Pharmacol. 2023, in press.
  • 204. Tharmalingam, N.; Xu, S.; Felix, L. O.; Roy, B.; Xian, M.; Mylonakis, E.; Fuchs, B. B. Gold complex compounds that inhibit drug-resistant Staphylococcus aureus by targeting thioredoxin reductase. Front. Antibiot. 2023, 2, 1179354.
  • 203. Lindahl, S.; Xian, M. Recent development of polysulfides: Chemistry and biological applications. Curr. Opin. Chem. Biol. 2023, 75, 102325.
  • 202. Roy, B.; Shieh, M.; Ramush, G.; Xian, M. Organelle-targeted fluorescent probes for sulfane sulfur species. Antioxidants 2023, 12, 590.
  • 201. Li, Z.; Xia, H.; Sharp, III, T. E.; LaPenna, K. B.; Katsouda, A.; Elrod, J. W.; Pfeilschifter, J.; Beck, K. -F.; Xu, S.; Xian, M.; Goodchild, T. T.; Papapetropoulos, A.; Lefer, D. J. Endothelium-derived hydrogen sulfide modulates endothelial-mesenchymal transition in heart failure. Circulation Research, 2023, 132, 154-166.
  • 200. Roy, B.; Shieh, M.; Xu, S.; Ni, X.; Xian, M. A single component photo-responsive template for the controlled release of NO and H2S2.  J. Am. Chem. Soc., 2023, 145, 277-287.
  • 199. Day, J. J.; Zhang, T.; Hamsath, A.; Neill, D. L.; Xu, S.; Qian, W. -J.; Xian, M. A chemical approach for the specific generation of cysteine sulfinylation. Tetrahedron Lett. 2023, 114, 154284. (Special issue in honor of Prof. John Wood).
  • 198. Shieh, M.; Xu, S.; Lederberg, O. L.; Xian, M. Detection of sulfane sulfur species in biological systems. Redox Biol. 2022, 57, 102502.
  • 197. Cui, Q.; Pan, T. W.; Shieh, M.; Kelly, S. S.; Xu, S.; Qian, W. J.; Xian, M. Controllable cycloadditions between 2H-(thio)pyran-2-(thi)ones and strained alkynes: a click-and-release strategy for COS/H2S generation. Org. Lett., 2022, 24, 7334-7338.
  • 196. Hamsath, A.; Lederberg, O. L.; Cui, Q.; Shieh, M.; Lam, Y.; Brummett, B. J.; Xu, S.; Robinson, J. R.; Xian, M. Intramolecular tetrazine-acryloyl cycloaddition: chemistry and applications. Chem. Sci. 2022, 13, 10336-10341.
  • 195. Shieh, M.; Ni, X.; Xu, S.; Lindahl, S. P.; Yang, M.; Matsunaga, T.; Flaumenhaft, R.; Akaike, T.; Xian, M. Shining a light on SSP4: a comprehensive analysis and biological applications for the detection of sulfane sulfurs. Redox Biol. 2022, 56, 102433.
  • 194. Li, Z.; Xia, H.; Sharp III, T. E.; LaPenna, K. B.; Elrod, J. W.; Casin, K. M.; Liu, K.; Calvert, J. W.; Chau, V. Q.; Salloum, F. N.; Xu, S.; Xian, M.; Nagahara, N.; Goodchild, T. T.; Lefer, D. J. Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure. Circulation Research 2022, 131, 222-235.
  • 193. Kelly, S. S.; Ni, X.; Yuen, V.; Radford, M. N.; Xian, M. C-Nitrosothioformamide: a donor template for dual release of HNO and H2S. ChemBioChem 2022, 23, e202200101. (front cover)
  • 192. Xu, S.; Knight, J. R.; Brummett, B. J.; Shieh, M.; Cui, Q.; Wang, Y.; Ramush, G.; Xian, M. Benzothiazole-derived sulfones and sulfoxides as reactive templates for biothiols and sulfane sulfurs. Org. Lett. 2022, 24, 2546-2550.
  • 191. Amer, M.; Ni, X.; Xian, M.; Chen, R. K. Photo-responsive hydrogel Mns with interlocking control for easy extraction in sustained ocular drug delivery. ASME J. Eng. Sci. Med. Diagn. Ther. 2022, 5, 011001.
  • 190. Wang, Y.; Ni, X.; Chadha, R.; McCartney, C.; Lam, Y.; Brummett, B.; Ramush, G.; Xian, M. Methods for suppressing hydrogen sulfide in biological systems. Antioxid. Redox Signal. 2022, 36, 294-308.
  • 189. Li, X.; Day, N. J.; Gaffrey, M. J.; Feng, S.; Lin, T. D.; Paurus, V. L.; Monroe, M.; Moore, R. J.; Yang, B.; Xian, M.; Qian, W. J. Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress. Redox Biol. 2021, 46, 102111.
  • 188. Ni, X.; Li, X.; Shen, T. L.; Qian, W. J.; Xian, M. A sweet H2S/H2O2 dual release system and specific protein S-persulfidation mediated by thioglucose/glucose oxidase. J. Am. Chem. Soc. 2021, 143, 13325-13332.
  • 187. Miyazaki, Y.; Marutani, E.; Ikeda, T.; Ni, X.; Hanaoka, K.; Xian, M.; Ichinose, F. A sulfonyl azide based sulfide scavenger rescues mice from lethal hydrogen sulfide intoxication. Toxicol. Sci. 2021, 183, 393-403.
  • 186. Ni, X.; Kelly, S. S.; Xu, S.; Xian, M. The path to controlled delivery of reactive sulfur species. Acc. Chem. Res. 2021, 54, 3968-3978.
  • 185. Marutani, E.; Morita, M.; Hirai, S.; Kai, S.; Grange, R. M. H.; Miyazaki, Y.; Nagashima, F.; Traeger, L.; Magliocca, A.; Ida, T.; Matsunaga, T.; Flicker, D. R.; Corman, B. H. P.; Mori, N.; Yamazaki, Y.; Batten, A.; Li, R.; Tanaka, T.; Ikeda, T.; Nakagawa, A.; Atochin, D.; Ihara, H.; Olenchock, B. A.; Shen, X.; Nishida, M.; Hanaoka, K.; Kevil, C. G.; Xian, M.; Bloch, D. B.; Akaike, T.; Hindle, A. G.; Motohashi, H.; Ichinose, F. Sulfide catabolism ameliorates hypoxic brain injury. Nat. Commun. 2021, 12, 3108.
  • 184. Kelly, S. S.; Shen, T. L.; Xian, M.; Oxygen-to-oxygen silyl migration of alpha-siloxy sulfoxides and oxidation-triggered allicin formation. Org. Lett. 2021, 23, 3741-3745.
  • 183. Wang, Y.; Lam, Y.; McCartney, C.; Brummett, B.; Ramush, G.; Xian, M. Fluorescent probes for H2S detection: cyclization-based approaches. A chapter for the book “Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies”, Wiley Series in Drug Discovery and Development, 2021, accepted.
  • 182. Wang, Y.; Cai, L.; Chen, W.; Wang, D.; Xu, S.; Wang, L.; Kononov, M. A.; Ji. S.; Xian, M. Development of xanthene-based fluorescent dyes: machine learning-assisted prediction vs TD-DFT prediction and experimental validation. Chemistry-Methods, 2021, 1, 389-396.
  • 181. Knight, J. R.; Wang, Y.; Xu, S.; Chen, W.; Berkman, C. E.; Xian, M. A modular template for the design of thiol-triggered sensors and prodrugs. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2021, 247, 119072. (invited paper for the special issue of fluorescent probes)
  • 180. Duan, J.; Zhang, T.; Gaffrey, M. J.; Weitz, K. K.; Moore, R. J.; Li, X.; Xian, M.; Thrall, B. D.; Qian, W. J. Stochiometric quantification of the thiol redox proteome of macrophages reveals subcellular compartmentalization and susceptibility to oxidative perturbations. Redox Biol. 2020, 36, 101649.
  • 179. Chen, W.; Xian, M. Washington Red (WR) dyes and their imaging applications. Meth. Enzymol. 2020, 640, 149-163.
  • 178. Wang, Y.; Xu, X.; Xian, M. Specific reactions of RSNO/HSNO/HNO and their applications in the design of fluorescent probes. Chem. Eur. J. 2020, 26, 11673-11683.
  • 177. Li, X.; Li, N.; Huang, L.; Xu, S.; Hamsath, A.; Dai, L.; Zhang, M.; Zhang, H.; Zheng, X.; Wong, J. J. L.; Xian, M.; Yang, C. T.; Liu, J. Is hydrogen sulfide a concern during treatment of lung adenocarcinoma with ammonium tetrathiomolybdate? Front. Oncol. 2020, 10, 234.
  • 176. Hamsath, A.; Xian, M. Chemistry and chemical biology of selenenyl sulfides (RSeSR) and thioseleninic acids (RSeSH). Antioxid. Redox Signal. 2020, 33, 1143-1157.
  • 175. Zhao, X.; Liu, L.; An, T.; Xian, M.; Luckanagul, J. A.; Su, Z.; Lin, Y.; Wang, Q. A hydrogen sulfide releasing alginate dressing for effective wound healing. Acta Biomaterialia, 2020, 104, 85-94.
  • 174. Hamsath, A.; Xian, M. Trityl Thionitrite. Encyclo. Reagents for Org. Syn. 2020.
  • 173. Xu, S.; Wang, Y.; Parent, Z. T.; Xian, M. Diacyl disulfides as the precursors for hydrogen persulfides (H2S2). Bioorg. Med. Chem. Lett. 2020, 30, 126903.
  • 172. Olson, K. R.; Briggs, A.; Devireddy, M.; Xian, M.; Gao, Y. Are the beneficial effects of ‘antioxidant’ lipoic acid mediated through metabolism of reactive sulfur species? Free Radical Biol. Med. 2020, 146, 139-149.
  • 171. Yang, C. T.; Devarie-Baez, N. O.; Hamsath, A.; Fu, X. D.; Xian, M. S-Persulfidation: chemistry, chemical biology, and significance in health and disease. Antioxid. Redox Signal. 2020, 33, 1092-1114.
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  • 169. Chen, W.; Matsunaga, T.; Neill, D. L.; Yang, C. T.; Akaike, T.; Xian, M. Rational design of a dual-reactivity based fluorescent probe for visualizing intracellular HSNO. Angew. Chem. Int. Ed. 2019, 58, 16067-16070.
  • 168. Liu, J.; Liu, M.; Zhang, X.; Wei, X.; Wang, J.; Xian, M.; Guo, W. Exploring cysteine regulation in cancer cell survival with a highly specific “Lock and Key” fluorescent probe for cysteine. Chem. Sci. 2019, 10, 10065-10071.
  • 167. Wu, J.; Chen, A.; Zhou, Y.; Zheng, S.; Yang, Y.; An, Y.; Xu, K.; He, H.; Kang, J.; Luckanagull, J. A.; Xian, M.; Xiao, J.; Wang, Q. Novel H2S-releasing hydrogel for wound repair via in situ polarization of M2 macrophages. Biomaterials 2019, 222, 119398.
  • 166. Hu, Y.; Li, X.; Fang, Y.; Shi, W.; Li, X.; Chen, W.; Xian, M.; Ma, H. Reactive oxygen species-triggered off-on fluorescent donor for imaging hydrogen sulfide delivery in living cells. Chem. Sci. 2019, 10, 7690-7694.
  • 165. Yang, C. T.; Wang, Y.; Marutani, E.; Ida, T.; Ni, X.; Xu, S.; Chen, W.; Zhang, H.; Akaike, T.; Ichinose, F.; Xian, M. Data-driven identification of hydrogen sulfide scavengers. Angew. Chem. Int. Ed. 2019, 58, 10898-10902. This work was highlighted by Chemical & Engineering News 2019, V97, issue 26: https://cen.acs.org/synthesis/medicinal-chemistry/Datamining-hydrogen-sulfide-antidote/97/i26?utm_source=Newsletter&utm_medium=Newsletter&utm_campaign=CEN
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  • 163. Wang, H.; Xu, Y.; Rao, L.; Yang, C. T.; Yuan, H.; Gao, T.; Chen, X.; Sun, H.; Xian, M.; Liu, C.; Liu, C. A ratiometric fluorescent probe for monitoring endogenous methylglyoxal in living cells and diabetic blood samples. Anal. Chem. 2019, 91, 5646-5653.
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  • 121. Lv, W.; Yang, L.; Xu, C.; Shi, Z.; Shao, J.; Xian, M.; Chen, J. Cadmium disrupts the balance between hydrogen peroxide and superoxide radical by regulating endogenous hydrogen sulfide in the root tip of Brassica rapa. Front. Plant Sci. 2017, 8, 232.
  • 120. Shinkai, Y.; Masuda, A.; Akiyama, M.; Xian, M.; Kumagai, Y. Cadmium-mediated activation of the HSP90/HSF1 pathway regulated by reactive persulfides/polysulfides. Toxicol. Sci. 2017, 156, 412-421.
  • 119. Peng, B.; Liu, C.;; Li, Z.; Day, J. J.; Lu, Y.; Lefer, D. J.; Xian, M. Slow generation of hydrogen sulfide from sulfane sulfurs and NADH models. Bioorg. Med. Chem. Lett. 2017, 27, 542-545.
  • 118. Meng, G.; Xiao, Y.; Ma, Y.; Tang, X.; Xie, L.; Liu, J.; Gu, Y.; Yu, Y.; Park, C. M.; Xian, M.; Wang, X.; Ferro, A.; Wang, R.; Moore, P. K.; Zhang, Z.; Wang, H.; Han, Y.; Ji, Y. Hydrogen sulfide regulates KLF5 transcription activity via SP-1 sulfhydrylation at Cys664 to prevent myocardial hypertrophy. J. Am. Heart Assoc. 2016, 5, e004160.
  • 117. Wu, J.; Li, Y.; He, C.; Kang, J.; Ye, J.; Xiao, Z.; Zhu, J.; Chen, A.; Li, X.; Xiao, J.; Xian, M.; Wang, Q. Novel H2S releasing nano-fibrous coating for in vivo dermal wound regeneration. ACS Appl. Mater. Interfaces, 2016, 8, 27474-27481.
  • 116. Chen, W.; Pacheco, A.; Takano, Y.; Day, J. J.; Hanaoka, K.; Xian, M. A single fluorescent probe to visualize hydrogen sulfide and hydrogen polysulfide with different fluorescent signals. Angew. Chem. Int. Ed. 2016, 55, 9993-9996.
  • 115. Kang, J.; Li, Z.; Organ, C. L.; Park, C. M.; Yang, C. T.; Pacheco, A.; Wang, D.; Lefer, D. J.; Xian, M. pH-Controlled hydrogen sulfide release for myocardial ischemia reperfusion injury. J. Am. Chem. Soc. 2016, 138, 6336-6339.
  • 114. Sun, H.; Lu, D.; Xian, M.; Dong, C.; Shuang, S. A lysozyme-stabilized silver nanocluster fluorescent probe for the detection of sulfide ions. Anal. Methods 2016, 8, 4328-4333.
  • 113. Day, J. J.; Yang, Z.; Chen, W.; Pacheco, A.; Xian, M. Benzothiazole sulfinate: a water soluble and slow-releasing sulfur dioxide donor. ACS Chem. Biol. 2016, 11, 1647-1651.
  • 112. Wedmann, R.; Onderka, C.; Wei, S.; Szijártó, I. A.; Miljkovic, J.; Mitrovic, A.; Lange, M.; Savitsky, S.; Yadav, P. K.; Torregrossa, R.; Harrer, E. G.; Harrer, T.; Ishii, I.; Gollasch, M.; Wood, M. E.; Galardon, E.; Xian, M.; Whiteman, M.; Banerjee, R.; Filipovic, M. R. Improved Tag-Switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation. Chem. Sci. 2016, 7, 3414-3426.
  • 111. Park, C. M.; Johnson, B. A.; Duan, J.; Park, J. J.; Day, J. J.; Gang, D.; Qian, W. J.; Xian, M. 9-Fluorenylmethyl (Fm) disulfides: biomimetic precursors for persulfides. Org. Lett., 2016, 18, 904-907.
  • 110. Xu, S.; Yang, C.; Meng, F. H.; Pacheco, A.; Chen, L.; Xian, M. Ammonium tetrathiomolybdate as a water-soluble and slow-release hydrogen sulfide donor. Bioorg. Med. Chem. Lett. 2016, 26, 1585-1588.
  • 109. Kim, W.; Peever, T. L.; Park, J. J.; Park, C. M.; Gang, D. R.; Xian, M.; Davidson, J. A.; Infantino, A.; Kaiser, W. J.; Chen, W. Use of metabolomics for the chemotaxonomy of legume-associated Ascochyta and allied genera. Scientific Reports 2016, 6, 20192.
  • 108. Park, C.-M.; Biggs, T.; Xian, M. Proline-based phosphoramidite reagents for the reductive ligation of S-nitrosothiols. J. Antibiotics 2016, 69, 313-318. (invited contribution in honor of Prof. Amos B. Smith, III’s 50 years scientific career).
  • 107. Xie, L.; Feng, H.; Li, S.; Meng, G.; Liu, S.; Tang, X.; Ma, Y.; Han, Y.; Xiao, Y.; Gu, Y.; Shao, Y.; Park, C.-M.; Xian, M.; Huang, Y.; Ferro, A.; Wang, R.; Moore, P. K.; Wang, H.; Ji, Y. SIRT3 mediates the anti-oxidant effect of hydrogen sulfide in endothelial cells. Antioxid. Redox Signal. 2016, 24, 329-343.
  • 106. Feng, S.; Zhao, Y.; Xian, M.; Wang, Q. Biological thiols-triggered hydrogen sulfide releasing microfibers for tissue engineering applications. Acta Biomaterialia 2015, 27, 205-213.
  • 105.  Zhao, Y.; Yang, C.; Organ, C.; Li, Z.; Bhushan, S.; Otsuka, H.; Pacheco, A.; Kang, J.; Aguilar, H. C.; Lefer, D. J.; Xian, M. Design, synthesis, and cardioprotective effects of N-mercapto-based hydrogen sulfide donors. J. Med. Chem., 2015, 58, 7501-7511.
  • 104.  Chen, W.; Rosser, E. W.; Matsunaga, T.; Pacheco, A.; Akaike, T.; Xian, M. The development of fluorescent probes for visualizing intracellular hydrogen polysulfides. Angew. Chem. Int. Ed. 2015, 54, 13961-13965.
  • 103.  Zhang, C.; Peng, B.; Chen, W.; Shuang, S.; Xian, M.; Dong, C. A ratiometric fluorescent probe for hydrogen sulfide based on the nucleophilic substitution-cyclization of diselenides. Dyes Pigments, 2015, 121, 299-304.
  • 102.  Sattler, S. A.; Wang, X.; Lewis, K. M.; DeHan, P. J.; Park, C. M.; Xin, Y.; Liu, H.; Xian, M.; Xun, L.; Kang, C. Characterizations of two bacterial persulfide dioxygenases of the metallo-β-lactamase superfamily. J. Biol. Chem. 2015, 290, 18914-18923.
  • 101.  Zhao, Y.; Pacheco, A.; Xian, M. Medicinal chemistry: insights into the development of novel H2S donors. Part VIII, p365-388. P.K. Moore, M. Whiteman (eds.), Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide, Handbook of Experimental Pharmacology 230, 2015.
  • 100.  Chen, W.; Rosser, E. W.; Zhang, D.; Shi, W.; Li, Y.; Dong, W.-J.; Ma, H.; Hu, D.; Xian, M. A specific nucleophilic ring-opening reaction of aziridines as a unique platform for the construction of highly selective hydrogen polysulfide probes. Org. Lett. 2015, 17, 2776-2779.
  • 99.  Park, C.-M.; Weerasinghe, L.; Day, J. J.; Fukuto, J. M.; Xian, M. Persulfides: current knowledge and challenges in chemistry and chemical biology. Mol. BioSyst. 2015, 11, 1775-1785. (invited review).
  • 98.  Biggs, T. D.; Weerasinghe, L.; Park, C.-M.; Xian, M. Phosphine-mediated conjugation of S-nitrosothiols and aldehydes. Tetrahedron Lett. 2015, 56, 2741-2743.
  • 97.  Peng, B.; Zhang, C.; Marutani, E.; Pacheco, A.; Chen, W.; Ichinose, F.; Xian, M. Trapping Hydrogen Sulfide (HS) with Diselenides: The Application in the Design of Fluorescent Probes. Org Lett 2015, 17, 1541-1544.
  • 96.  Miao, Z.; Reisz, J. A.; Mitroka, S. M.; Pan, J.; Xian, M.; King, S. B. A Selective Phosphine-Based Fluorescent Probe for Nitroxyl in Living Cells. Bioorg Med Chem Lett 2015, 25, 16-19.
  • 95.  Lin, V. S.; Chen, W.; Xian, M.; Chang, C. J. Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems. Chem. Soc. Rev. 2015, 44, 4596-4618.
  • 94.  Kim, W.; Park, C.-M.; Park, J.-J.; Akamatsu, H. O.; Peever, T. L.; Xian, M.; Gang, D. R.; Vandemark, G.; Chen, W. Functional Analyses of the Diels-Alderase Gene sol5 of Ascochyta Rabiei and Alternaria Solani Indicate That the Solanapyrone Phytotoxins Are Not Required for Pathogenicity. Mol Plant Microbe Interact 2015, 28, 482-496.
  • 93.  Park, C. M.; Xian, M. Use of phosphorodithioate-based compounds as hydrogen sulfide donors. Meth. Enzymol. 2015, 554, 127-142.
  • 92.  Peng, B.; Xian, M. Hydrogen Sulfide Detection Using Nucleophilic Substitution-Cyclization-Based Fluorescent Probes. Meth. Enzymol. 2015, 554, 47-62.
  • 91.  Park, C.-M.; Macinkovic, I.; Filipovic, M. R.; Xian, M. Chapter Three – Use of the “Tag-Switch” Method for the Detection of Protein S-Sulfhydration. Meth. Enzymol. 2015, 555, 39–56.
  • 90.  Chen, Y.; Mo, H. Z.; Zheng, M. Y.; Xian, M.; Qi, Z. Q.; Li, Y. Q.; Hu, L. B.; Chen, J.; Yang. L. F. Selenium inhibits root elongation by repressing the generation of endogenous hydrogen sulfide in Brassica rapa”. PLOS One 2014, 9, e110904.
  • 89.  Ono, K.; Akaike, T.; Sawa, T.; Kumagai, Y.; Wink, D.; Tantillo, D. J.; Hobbs, A. J.; Nagy, P.; Xian, M.; Lin, J.; Fukuto, J. M. The redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications to their possible biological activity and utility. Free Radical Biol. Med. 2014, 77, 82-94.
  • 88.  Sakaguchi, M.; Marutani, E.; Shin, H. S.; Hanaoka, K.; Chen, W.; Xian, M.; Ichinose, F. Sodium thiosulfate attenuates acute lung injury in mice. Anesthesiology 2014, 121, 1248-1257.
  • 87.  Yang, C.T.; Zhao, Y.; Xian, M.; Bai, H.; Liu, G.; Xu, J.; Zhang, M. “A novel controllable hydrogen sulfide releasing moledule protects human skin keratinocytes against methylglyoxal-induced injury and dysfunction”. Cell. Physiol. Biochem. 2014, 34, 1304-1317.
  • 86.  Liu, C.; Zhang, F.; Munske, G.; Zhang, H.; Xian, M. “Isotope dilution mass spectrometry for the quantification of sulfane sulfurs”. Free Radical Biol. Med. 2014, 76, 200-207.
  • 85.  Zhao, Y.; Kang, J.; Park, C. M.; Bagdon, P. E.; Xian, M. “Thio-activated gem-dithiols:  A new class of controllable hydrogen sulfide donors. Org Lett. 2014, 16, 4536-4539.
  • 84.  Marutani, E.; Chen, W.; Sasakura, K.; Liu, J.; Xian, M.; Hanaoka, K.; Nagano, T.; Ichinose, F. “Cytoprotective effects of hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonists are mediated by intracellular sulfane sulfur.” Med Chem Comm. 2014. 5, 1577-1583.
  • 83.  Zhang, D.; Chen, W.; Kang, J.; Ye, Y.; Zhao, Y.; Xian, M. “Highly Selective Fluorescence Off–on Probes for Biothiols and Imaging in Live Cells”. Org. Biomol. Chem. 2014, 12, 6837–6841.
  • 82.  Peng, B.; Xian, M. “Fluorescent Probes for Hydrogen Sulfide Detection”. Asian J. Org. Chem. 2014, 3, 914-924
  • 81.  Zhao, Y.; Biggs, T. D.; Xian, M. “Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications”. Chem. Commun. 2014, 50, 11788-11805
  • 80.  Liu, C.; Chen, W.; Shi W.; Peng, Bo; Zhao, Y. Ma, H.; Xian, M. “Rational Design and Bioimaging Applications of Highly Selective Fluorescent Probes for Hydrogen Polysulfides” J. Am. Chem. Soc., 2014, 136, 7257-7260.
  • 79.  Ida, T.; Sawa, T.; Ihara, H.; Tsuchiya, Y.; Watanabe, Y.; Kumagai, Y.; Suematsu, M.; Motohashi, H.; Fujii, S.; Matsunaga, T.; Yamamoto, M.; Ono, K.; Devarie-Baez, N. O.; Xian, M.; Fukuto, J. M.; Akaike, T. “Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling”. Proc. Natl. Acad. Sci. USA. 2014, 111, 7606-7611.
  • 78.  Zhang, D.; Chen, W.; Miao, Z.; Ye, Y.; Zhao, Y.; King, S. B.; Xian, M. “A reductive ligation based fluorescent probe for S-nitrosothiols”. Chem. Commun., 2014,50, 4806-4809
  • 77.  Li, Y.-J.; Chen, J.; Xian, M.; Zhou, L.-G.; Han, F. X.; Gan, L.-J.; Shi, Z.-Q. “In site bioimaging of hydrogen sulfide uncovers its pivotal role in regulating nitric oxide-induced lateral root formation.” PLOS One, 2014, 9, e90340.
  • 76.  Zhang, D.; Macinkovic, I.; Devarie-Baez, N. O.; Pan, J.; Park, C.-M.; Carroll, K. S.; Filipovic, M. R.; Xian, M. “Detection of Protein S-Sulfhydration by a Tag-Switch Technique.” Angew. Chem. Int. Ed. 2014, 53, 575 –581. (selected as a hot paper for the months, January/February, of European Network on Gasotransmitters)
  • 75.  Peng, B.; Chen, W.; Liu, C.; Rosser, E. W., Pacheco, A.; Zhao, Y.; Aguilar, H. C.; Xian, M. “Fluorescent probes on nucleophilic substitution-cyclization for hydrogen sulfide detection and bioimaging.” Chem. Eur. J. 2014, 20, 1010 – 1016.
  • 74.  Park, C.-M.; Zhao, Y.; Zhu, Z.; Pacheco, A.; Peng, B. Devarie-Baez, N.; Bagdon, P.; Zhang, H.; Xian, M. “Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors” Mol. BioSys. 2013, 9, 2430-2434
  • 73.  Devarie-Baez, N.; Bagdon, P.; Peng, B.; Zhao, Y.; Park, C.-M., Xian, M. “Light-induced hydrogen sulfide release from “Caged” gem-dithiols” Org. Lett. 2013, 15, 2786-2789.
  • 72.  Chen, W.; Liu, C.; Peng, B.; Zhao, Y.; Pacheco, A.; Xian, M. “New fluorescent probe for sulfane sulfurs and the application in bioimaging” Chemical Science 2013, 4, 2892-2896.  (highlighted in ChemistryWorld).
  • 71.  Devarie, N. O.; Zhang, D.; Li, S.; Whorton, A. R. Xian, M. “Direct methods for the detection of protein S-nitrosation”. Methods 2013, 62, 171-176.
  • 70.  Zhao, Y.; Bhushan, S.; Yang, C.; Otsuka, H.; Stein, J. D.; Pacheco, A.; Peng, B.; Devarie, N. O.; Aguilar, H. C.; Lefer, D. J.; Xian, M. “Controllable hydrogen sulfide donors and the activity against myocardial ischemia-reperfusion injury” ACS Chem. Biol. 2013, 8, 1283-1290. (highlighted in C&EN)
  • 69.  Markand, S.; Tawfik, A.; Ha, Y.; Gnana-Prakasam, J.; Sonne, S.; Ganapathy, V.; Sen, N.; Xian, M.; Smith, S. B. “Cystathionine beta synthase expression in mouse retina”. Curr. Eye. Res. 2013, 38, 597-604.
  • 68.  Talipov, M. R.; Khomyakov, D. G.; Xian, M.; Timerghazin, Q. K. “Computational design of S-nitrosothiol ‘Click’ reactions”. J. Comput. Chem. 2013. 34, 1527-1530.
  • 67.  Zhang, D.; Devarie-Baez, N. O.; Li, Q.; Lancaster, J. R. Jr.; Xian, M. “Methylsulfonyl benzothiozole (MSBT): a selective protein thiol blocking reagent”. Org. Lett. 2012, 14, 3396.
  • 66.  Park, C. –M.; Niu, W.; Liu, C.; Biggs, T. D.; Guo, J.; Xian, M. “A proline based phosphine template for Staudinger ligation”. Org. Lett. 2012, 14, 4697.
  • 65.  Liu, C.; Peng, B.; Li, S.; Park, C. –M.; Whorton, A. R.; Xian, M. “Reaction based fluorescent probes for hydrogen sulfide”. Org. Lett. 2012, 14, 2184.
  • 64.  Li, S.; Wang, H.; Xian, M.; Whorton, A. R. “Identification of protein nitrosothiols using phosphine-mediated selective reduction”. Nitric Oxide 2012, 26, 20.
  • 63.  Liu, C.; Pan, J.; Li, S.; Zhao, Y.; Wu, L. Y.; Berkman, C. E.; Whorton, A. R.; Xian, M. “Capture and visualization of hydrogen sulfide by a fluorescent probe”. Angew. Chem. Int. Ed. 2011, 50, 10327.
  • 62.  Pan, J.; Devarie, N. O.; Xian, M. “Facile amide formation via S-nitrosothioacids”. Org. Lett. 2011, 13, 1092.
  • 61.  Liu, X.; Wang, Y.; Cao, Y.; Yadama, V.; Xian, M.; Zhang, J. “Study of dextrin-derived curing agent for waterborne epoxy adhesive. Carbohyd. Polym. 2011, 83, 1180.
  • 60.  Zhao, Y.; Wang, H.; Xian, M. “Cysteine activated hydrogen sulfide (H2S) donors”. J. Am. Chem. Soc. 2011, 133, 15.
  • 59.  Wang, H.; Xian, M. “Chemical methods to detect S-nitrosation”. Curr. Opin. Chem. Biol. 2011, 15, 32.
  • 58.  Pan, J.; Xian, M. “Disulfide formation via sulfenamides”. Chem. Commun. 2011, 352. (Emerging Investigators Issue).
  • 57.  Zhang, D. H.; Davarie-Baez, N. O.; Pan, J.; Wang, H.; Xian, M. “One-pot thioether formation from S-nitrosothiols“. Org. Lett. 2010. 12, 5674.
  • 56.  Zhang, J.; Li, S.; Zhang, D.; Wang, H.; Whorton, R.; Xian, M. “Reductive ligation mediated one-step disulfide formation of S-nitrosothiols“. Org. Lett. 2010, 12, 4208.
  • 55.  Devarie, N.; Xian, M. “Facile preparation of 3-substituted benzisothiazoles from o-mercapto-acylphenones”. Org. Lett. 2010, 12, 752.
  • 54.  Wang, H.; Zhang, J.; Xian, M. “Facile formation of dehydroalanine from S-nitrosocysteines”. J. Am. Chem. Soc. 2009, 131, 13238.
  • 53.  Wang, H.; Liu, X.; Liu, B.; Zhang, J.; Xian, M. “Synthesis of rosin-based flexible anhydride type curing agents and properties of the cured epoxy”. Polym. Int. 2009, 58, 1435.
  • 52.  Zhang, J.; Wang, H.; Xian, M. “An unexpected bis-ligation of S-nitrosothiols”. J. Am. Chem. Soc. 2009, 131, 3854. (this work is featured by Chemical & Engineering News 2009, March 16, Vol 87).
  • 51.  Devarie, N.; Kim, W.; Smith, A. B. III, Xian, M. “Multicomponent type II anion relay chemistry (ARC): one-pot syntheses of 2,3-disubstituted furans and thiophenes exploiting 2-trialkylsilyl-3-formyl bifunctional linchpins”. Org. Lett. 2009, 11, 1861.
  • 50.  Pan, J.; Downing, J. A.; McHale, J. L.; Xian, M. “A fluorogenic dye activated by S-nitrosothiols”. Mol. BioSyst. 2009, 5, 918. (Emerging Investigators Issue)
  • 49.  Zhang, J.; Wang, H.; Xian, M. “Exploration of the traceless reductive ligation of S-nitrosothiols”. Org. Lett. 2009, 11, 477.
  • 48.  Wang, H.; Liu, B.; Liu, X.; Zhang, J.; Xian, M. “Synthesis of biobased epoxy and curing agents using rosin and study of cure reactions”. Green Chem. 2008, 10, 1190.
  • 47.  Wang, H.; Shuhler, B. J.; Xian, M. “Total synthesis of diospongins A and B”. Synlett 2008, 2651.
  • 46.  Wang, H.; Xian, M. “Fast reductive ligation of S-nitrosothiols”. Angew Chem. Int. Ed. 2008, 47, 6598.
  • 45.  Xian, M.; Zhu, C-J. “2-[Bis-(3,5-bistrifluoromethyl)-phenyl]-[(trimethylsilyl)oxy]-methyl]-pyrrolidine.” Encyclo. Reagents for Org. Syn. 2008.
  • 44.  Devarie, N.; Shuhler, B. J.; Wang, H.; Xian, M. “Solvent controlled C(sp2)O silyl migration: the one-pot synthesis of 2,3-disubstituted thiophenes”  Org. Lett. 2007, 9, 4655.
  • 43.  Wang, H.; Shuhler, B. J. Xian, M. “A versatile strategy for the synthesis of 2,6-disubstituted dihydropyranones” J. Org. Chem. 2007, 72, 4280.
  • 42.  Xian, M.; Shuhler, B. J. “Study of the synthesis of poecillanosine” Tetrahedron Lett. 2007, 48, 1209.

    Publications from postdoctoral research (UPenn)

     

  • 41.  Shaw, S. J.; Menzella, H. G.; Myles, D. C.; Xian, M.; Smith, A. B., III. “Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity as the natural product-a further simplification of the lactone region” Org. Biomol. Chem., 2007, 5, 2753.
  • 40.  Smith, A. B., III; Kim, D.-S.; Xian, M. “Anion relay chemistry extended.  Synthesis of a gorgonian sesquiterpene” Org. Lett. 2007, 9, 3307.
  • 39.  Smith, A. B., III; Xian, M.; Kim, W. –S.; Kim, D.-S. “The 1,5-Brook rearrangement: an initial application in anion relay chemistry” J. Am. Chem. Soc. 2006, 128, 12368.
  • 38.  Smith, A. B., III; Xian, M. “Anion relay chemistry: an effective tactic for diversity oriented synthesis” J. Am. Chem. Soc. 2006, 128, 66. (This work is featured by Chemical & Engineering News 2006, January 2, Vol 84).
  • 37.  Smith, A. B., III; Xian, M. “Design, synthesis and biological evaluation of simplified analogues of discodermolide, additional insights on the importance of the diene, the C(7) hydroxyl, and the lactone” Org. Lett. 2005, 7, 5229.
  • 36.  Smith, A. B., III; Xian, M.; Liu, F. “Design, total synthesis and evaluation of C13,C14 cyclopropane analogues of discodermolide” Org. Lett. 2005, 7, 4613.
  • 35.  Shaw, S. J.; Sundermann, K. F.; Burlingame, M. A.; Myles, D. C.; Freeze, B. S.; Xian, M.; Brouard, I.; Smith, A. B., III. “Toward understanding how the lactone moiety of discodermolide affects activity” J. Am. Chem. Soc. 2005, 127, 6532.
  • 34.  Smith, A. B., III; Freeze, B. S.; Xian, M.; Hirose, T. “Total synthesis of (+)-Discodermolide: A highly convergent fourth-generation approach” Org. Lett. 2005, 7. 1825.
  • 33.  Smith, A. B., III; Freeze, B. S.; LaMarche, M. J.; Hirose, T.; Brouard, I.; Xian, M.; Myles, D. C.; Sundermann, K. F.; Shaw, S. J.; Burlingame, M. A. “Design, synthesis and evaluation of analogues of (+)-14-normethyldiscodermolide” Org. Lett. 2005, 7, 315.
  • 32.  Smith, A. B. III; Freeze, B. S.; LaMarche, M. J.; Hirose, T.; Brouard, I.; Rucker, P. V.; Xian, M.; Myles, D. C.; Sundermann, K. F.; Shaw, S. J.; Burlingame, M. A. “Carbamate-substituted analogues of (+)-discodermolide” Org. Lett. 2005, 7, 311.

    Publications from graduate research (Nankai & Wayne State)

     

  • 31.  Zhu, L.; Kedenburg, J.; Xian, M.; Wang, P. G. “A systematic strategy for preparation of uncommon sugars through enzymatic resolution and ring closing metathesis” Tetrahedron Lett., 2005, 46, 811-813.
  • 30.  Cheng, H.; Xian, M.; Wu, J.; Tunac, J. B.; Sun, D.; Wang, P. G. “Synthesis and enzyme-specific activation of carbohydrate-geldanamycin conjugates with potent anticancer activity” J. Med. Chem. 2005, 48, 645-652.
  • 29.  Xian, M.; Fatima, Z.; Zhang, W.; Fang, J.; Pei, D.; Loo, J.; Stevenson, T.; Wang, P. G. “Identification of alpha-Gal epitope mimetics through rapid generation and screening of C-linked glycopeptide library” J. Comb. Chem. 2004, 6, 126-134.
  • 28.  Jia, Q.; Cai, T.; Huang, M. Li, H.; Xian, M.; Poulos, T. L.; Wang, P. G. “Isoform-selective substrates of nitric oxide synthases” J. Med. Chem., 2003, 46, 2271.
  • 27.  Li, H.; Shimizu, H.; Flinspach, M.; Jamal, J.; Yang, W.; Xian, M.; Cai, T.; Wen, Z.; Jia, Q.; Wang, P. G.; Poulos, T. L. “The novel binding mode of N-alkyl-N’-hydroxyguanidine to nNOS provide mechanistic insights into NO biosynthesis” Biochemistry 2002, 41, 13868.
  • 26.  Jia, Q.; Janczuk, A.; Cai, T.; Xian, M.; Wen, Z.; Wang, P. G. “NO donors with anticancer activity” Expt. Opin. Therap. Pat. 2002. 12, 819.
  • 25.  Cai, T. W.; Xian, M.; Wang, P. G. “Electrochemical and peroxidase oxidation study of N-hydroxyguanidine derivatives as NO donors” Bioorg. Med. Chem. Lett. 2002, 12, 1507.
  • 24.  Wu, X.; Tang, X.; Xian, M.; Brauschweiger, P. G.; Wang, P. G. “Synthesis and cytotoxicities of mannose conjugated SNAP” Bioorg. Med. Chem. 2002, 10, 2303.
  • 23.  Xian, M.; Fujiwara, N.; Cai, T.; Wen, Z.; Kazuma, S.; Janczuk, A.; Tang, X.; Telyatnikov, V.; Miyamoto, Y.; Taniguchi, N.; Wang, P. G. “Novel substrates for nitric oxide synthases” Bioorg. Med. Chem. 2002, 10, 3049-3055.
  • 22.  Wang, P. G.; Xian, M.; Tang, X. -P.; Wu, X. –J; Wen, Z.; Cai, T. –W. “Nitric oxide donors: chemical activities and biological applications” Chem. Rev. 2002, 102, 1091.
  • 21.  Chen, X. C.; Wen, Z.; Xian, M.; Wang, K.; Ramachandran, N.; Schlegel, H. B.; Mutus, B.; Wang, P. G.  “Fluorophore-labeled S-nitrosothiols”  J. Org. Chem., 2001, 66, 6064.
  • 20.  Xian, M.; Li, X. P.; Tang, X. P.; Chen, X. C.; Zheng, X. L.; Galligan, J. J.; Kreulen, D. L.; Wang, P. G.  “N-hydroxyl derivatives of guanidine based drugs as enzymatic NO donors”  Bioorg. Med. Chem. Lett. 2001, 11, 2377-2380.
  • 19. Wu, X. J.; Tang, X. P.; Xian, M.; Wang, P. G.  “Glycosylated diazeniumdiolates: a novel class of enzyme-activated nitric oxide donors”  Tetrahedron Lett. 2001, 42, 3779.
  • 18. Tang, X. P.; Xian, M.; Trikha, M.; Honn, K. V.; Wang, P. G. “Synthesis of peptide-diazeniumdiolate conjugates: towards enzyme activated antitumor agents”  Tetrahedron Lett. 2001, 42, 2625.
  • 17. Wang, K.; Wen, Z.; Zhang, W.; Xian, M.; Cheng, J. P.; Wang, P. G.  “Equilibrium and kinetics studies of transnitrosation between S-nitrosothiols and thiols”  Bioorg. Med. Chem. Lett. 2001, 11, 433.
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