Recent Publications

Candida albicans isolates 529L and CHN1 exhibit stable colonization of the murine gastrointestinal tract2021. mBio.  12(6):e0287821. doi: 10.1128/mBio.02878-21. McDonough LD,  Mishra AA, Toscini N, Kakade P, Penumutchu S, Liang S-H, Maufrais C, Zhai B, Taur Y, Belenky P, Bennett RJ*, Hohl T*, Koh AY*, Ene IV*.

Intraspecies profiling reveals key regulators of Candida albicans pathogenic traits.  2021.  mBio. 12(2):e00586-21.  doi: 10.1128/mBio.00586-21.  Wang JM, Woodruff AL, Dunn MJ, Fillinger RJ, Bennett RJ, Anderson AZ.

Comparative genomics of white and opaque cell states supports an epigenetic mechanism of phenotypic switching in Candida albicans.  2021. G3 (Bethesda). 11(2):jkab001. doi: 10.1093/g3journal/jkab001.  Beekman CN, Cuomo CA, Bennett RJ, Ene IV.

 Adaptation to the dietary sugar D-tagatose via genome instability in polyploid Candida albicans cells.  2021. G3 (Bethesda).  11(7): jkab110. doi: 10.1093/g3journal/jkab110.  Thomson GJ, Kakade P, Hirakawa MP, Ene IV, Bennett RJ.

Epigenetic cell fate in Candida albicans is controlled by transcription factor condensates acting at super-enhancer-like elements.  2020.  Nature Micro. 5(11):1374-1389. Frazer C, Staples MI, Kim Y, Hirakawa M, Dowell MA, Johnson NV, Hernday AD, Ryan VH, Fawzi NL, Finkelstein IJ, Bennett RJ.

Older Publications

Hemizygosity enables a mutational transition governing fungal virulence and commensalism. Cell Host Microbe. 2019  25(3):418-431.e6. Liang SH, Anderson MZ, Hirakawa MP, Wang JM, Frazer C, Alaalm LM, Thomson GJ, Ene IV, Bennett RJ.

Metabolism-induced oxidative stress and DNA damage selectively trigger genome instability in polyploid fungal cells.  EMBO J2019.  38(19):e101597.  Thomson GJ, Hernon C, Austriaco N, Shapiro RS, Belenky P, Bennett RJ. 

A ‘parameiosis’ drives depolyploidization and homologous recombination in Candida albicans.  Nature Comm. 2019. 10(1):4388. doi: 10.1038/s41467-019-12376-2.  Anderson MZ, Thomson GJ, Hirakawa MP, Bennett RJ.   

The impact of gene dosage and heterozygosity on the diploid pathobiont Candida albicans. J Fungi (Basel). 2019.  6(1):10. doi: 10.3390/jof6010010.  Liang SH, Bennett RJ.  

Genetic modification of closely related Candida species.  Front Microbiol. 2019. 10:357. doi: 10.3389/fmicb.2019.00357.  Mancera E, Frazer C, Porman AM, Ruiz-Castro S, Johnson AD, Bennett RJ.

Galleria mellonella as an insect model for P. destructans, the cause of White-nose Syndrome in bats.  PLoS One.  2018. 13(9):e0201915. doi: 10.1371/journal.pone.0201915. Beekman CN, Meckler L, Kim E, Bennett RJ.


The genome of the human pathogen Candida albicans is shaped by mutation and cryptic sexual recombinationmBio.  2018. 9(5):e01205-18.  doi: 10.1128/mBio.01205-18.  Wang JM, Bennett RJ, Anderson MZ.


Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.  Proc Natl Acad Sci USA. 2018. 115(37):E8688-E8697. doi: 10.1073/pnas.1806002115. Ene IV, Farrer RA, Hirakawa MP, Agwamba K, Cuomo CA, Bennett RJ.  


Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia. Nat Commun. 2018. 9(1):2470.  Rosenberg A, Ene IV, Bibi M, Zakin S, Segal ES, Ziv N, Dahan AM, Colombo AL, Bennett RJ, Berman J.

A coupled process of same- and opposite-sex mating generates polyploidy and genetic diversity in Candida tropicalis. PLoS Genet. 2018. 14(5):e1007377. doi: 10.1371/journal.pgen.1007377. Du H, Zheng Q, Bing J, Bennett RJ, Huang G.


Epigenetic control of pheromone MAPK signaling determines sexual fecundity in Candida albicans.   Proc Natl Acad Sci USA. 2017. 114(52):13780-13785. doi: 10.1073/pnas.1711141115. Scaduto CM, Kabrawala S, Thomson GJ, Scheving W, Ly A, Anderson MZ, Whiteway M,Bennett RJ.

Parasex generates phenotypic diversity de novo and impacts drug resistance in Candida albicans Genetics. 2017. 207(3):1195-1211. doi: 10.1534/genetics.117.300295.  Hirakawa MP, Chyou DE, Huang D, Slan AR, Bennett RJ. 

Negative regulation of filamentous growth in Candida albicans by Dig1p.  Mol Microbiol. 2017 Sep;105(5):810-824. doi: 10.1111/mmi.13738. Regan H, Scaduto CM, Hirakawa MP, Gunsalus K, Correia-Mesquita TO, Sun Y, Chen Y, Kumamoto CA, Bennett RJ, Whiteway M. 

Development of a CRISPR-Cas9 System for efficient genome editing of Candida lusitaniae. mSphere. 2017. 2(3):e00217-17. doi: 10.1128/mSphere.00217-17. Norton EL, Sherwood RK, Bennett RJ.

A chromosome 4 trisomy contributes to increased fluconazole resistance in a clinical isolate of Candida albicans. Microbiology. 2017. 163(6):856-865. doi: 10.1099/mic.0.000478. Anderson MZ, Saha A, Haseeb A, Bennett RJ.


Phenotypic profiling reveals that Candida albicans opaque cells represent a metabolically specialized cell state compared to default white cells. mBio. 2016. 7(6):e01269-16. doi: 10.1128/mBio.01269-16. Ene IV, Lohse MB, Vladu AV, Morschhäuser J, Johnson AD, Bennett RJ.

Fungal Sex: The Ascomycota. Microbiol Spectr. 2016. Oct;4(5). doi: 10.1128/microbiolspec.FUNK-0005-2016.  Bennett RJ, Turgeon BG.


Deletion of a Yci1 domain protein of Candida albicans allows homothallic mating in MTL heterozygous cells. mBio. 2016.  7(2):e00465-16. doi: 10.1128/mBio.00465-16. Sun Y, Gadoury C, Hirakawa MP, Bennett RJ, Harcus D, Marcil A, Whiteway M.mBio. 

A multistate toggle switch defines fungal cell fates and is regulated by synergistic genetic cues. PLoS Genet. 2016. 12(10):e1006353. doi: 10.1371/journal.pgen.1006353. Anderson MZ, Porman AM, Wang N, Mancera E, Huang D, Cuomo CA, Bennett RJ. 

Phenotypic plasticity regulates Candida albicans interactions and virulence in the vertebrate host.  Front Microbiol. 2016.  7:780. doi: 10.3389/fmicb.2016.00780. Mallick EM, Bergeron AC, Jones SK Jr, Newman ZR, Brothers KM, Creton R, Wheeler RT, Bennett RJ

Systematic genetic screen for transcriptional regulators of the Candida albicans white-opaque switch. Genetics. 2016. 203(4):1679-92. doi: 10.1534/genetics.116.190645. Lohse MB, Ene IV, Craik VB, Hernday AD, Mancera E, Morschhäuser J, Bennett RJ, Johnson AD.

Evolutionary selection on barrier activity: Bar1 is an aspartyl protease with novel substrate specificity. mBio. 2015.  6(6):e01604-15. doi: 10.1128/mBio.01604-15. Jones SK Jr, Clarke SC, Craik CS, Bennett RJ.


The parasexual lifestyle of Candida albicans. Curr Opin Microbiol. 2015.  28:10-7. doi: 10.1016/j.mib.2015.06.017. Bennett RJ.


Candida albicans the chameleon: transitions and interactions between multiple phenotypic states confer phenotypic plasticity. Curr Opin Microbiol. 2015. 26:102-8. doi: 10.1016/j.mib.2015.06.016. Scaduto CM, Bennett RJ. 

Candida albicans kinesin Kar3 depends on a Cik1-like regulatory protein for its roles in mating, cell morphogenesis, and bipolar spindle formation.  Eukaryot Cell. 2015. Aug;14(8):755-74. doi: 10.1128/EC.00015-15.  Frazer C, Joshi M, Delorme C, Davis D,Bennett RJ, Allingham JS.

Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome. Proc Natl Acad Sci USA. 2015. 112(24):7478-83. doi: 10.1073/pnas.1507082112. O’Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ.

Finding a missing gene: EFG1 regulates morphogenesis in Candida tropicalis. G3 (Bethesda). 2015.  5(5):849-56. doi: 10.1534/g3.115.017566.  Mancera E, Porman AM, Cuomo CA, Bennett RJ, Johnson AD.

Genetic and phenotypic intra-species variation in Candida albicansGenome Res. 2015.  25(3):413-25. doi: 10.1101/gr.174623.114.  Hirakawa MP, Martinez DA, Sakthikumar S, Anderson MZ, Berlin A, Gujja S, Zeng Q, Zisson E, Wang JM, Greenberg JM, Berman J, Bennett RJ, Cuomo CA. 

Rapid mechanisms for generating genome diversity: whole ploidy shifts, aneuploidy, and loss of heterozygosity.  2014Cold Spring Harb Perspect Med. 4(10):a019604. doi: 10.1101/cshperspect.a019604. Bennett RJ, Forche A, Berman J.  

The cryptic sexual strategies of human fungal pathogens. 2014. Nat Rev Microbiol. 12(4):239-51. doi: 10.1038/nrmicro3236.  Ene IV, Bennett RJ.  

Sexual biofilm formation in Candida tropicalis opaque cells. 2014. Mol Microbiol. 92(2):383-98. doi: 10.1111/mmi.12565. Jones SK Jr, Hirakawa MP, Bennett RJ.

Convergent evolution of a fused sexual cycle promotes the haploid lifestyle. 2014. Nature. 506(7488):387-390. doi: 10.1038/nature12891. Sherwood RK, Scaduto CM, Torres SE, Bennett RJ.

Sensing of the microbial neighborhood by Candida albicans. 2013. PLoS Pathog. Mallick EM, Bennett RJ. 9(10):e1003661. doi: 10.1371/journal.ppat.1003661.

Parasexuality and ploidy change in Candida tropicalis. Eukaryot Cell. 2013. 12(12):1629-40. doi: 10.1128/EC.00128-13. Seervai RN, Jones SK Jr, Hirakawa MP, Porman AM, Bennett RJ. 

Genetic control of conventional and pheromone-stimulated biofilm formation in Candida albicans. PLoS Pathog. 2013. 9(4):e1003305. doi: 10.1371/journal.ppat.1003305. Lin CH, Kabrawala S, Fox EP, Nobile CJ, Johnson AD, Bennett RJ.  

MTL-independent phenotypic switching in Candida tropicalis and a dual role for Wor1 in regulating switching and filamentation. PLoS Genet. 2013. 9(3):e1003369. doi: 10.1371/journal.pgen.1003369. Porman AM, Hirakawa MP, Jones SK, Wang N, Bennett RJ. 

Candida albicans white and opaque cells undergo distinct programs of filamentous growth.  PLoS Pathog. 2013.  9(3):e1003210. doi: 10.1371/journal.ppat.1003210.  Si H, Hernday AD, Hirakawa MP, Johnson AD, Bennett RJ.  

Discovery of a phenotypic switch regulating sexual mating in the opportunistic fungal pathogen Candida tropicalisProc Natl Acad Sci USA. 2011. 27;108(52):21158-63. doi: 10.1073/pnas.1112076109. Porman AM, Alby K, Hirakawa MP, Bennett RJ. 

Defining pheromone-receptor signaling in Candida albicans and related asexual Candida species. Mol Biol Cell. 2011. 22(24):4918-30. doi: 10.1091/mbc.E11-09-0749. Lin CH, Choi A, Bennett RJ.  

Fungal mating pheromones: choreographing the dating game. Fungal Genet Biol. 2011. 48(7):668-76. doi: 10.1016/j.fgb.2011.04.001. Jones SK Jr, Bennett RJ. 

Interspecies pheromone signaling promotes biofilm formation and same-sex mating in Candida albicans Proc Natl Acad Sci USA. 2011. 108(6):2510-5. doi: 10.1073/pnas.1017234108. Alby K, Bennett RJ.