“Mechanistic evaluation of heart failure with preserved ejection fraction using non-invasive advanced imaging biomarkers.”
Heart failure with preserved ejection fraction (HFpEF) causes reduced functional tolerance and high morbidity and mortality. Treatment options are quite limited due to the syndrome’s heterogeneity. Understanding the biomechanical basis of cardiac dysfunction in HFpEF is necessary to identify new therapeutic strategies. This research will advance our understanding of the underlying pathophysiologic mechanisms of dysfunction including myocardial stiffness and energetics and their association with systolic function, diastolic function, and functional tolerance in patients with HFpEF using non-invasive advanced imaging methodologies including cardiac magnetic resonance and spectroscopy. It is expected to lead to a better understanding of disease mechanisms and ultimately, development of personalized therapies targeting these underlying pathophysiologic mechanisms in patients suffering from HFpEF.
This study is supported by National Institute of General Medical Sciences mentored grant, Ocean State Research Institute, CardioPulmonary Vascular Biology COBRE, Project number: 5P20GM103652-10, Sub-Project ID: 9499
About Dr. Imran
Dr. Tasnim F. Imran is a cardiologist and clinical research investigator at the Providence VA Healthcare System, Lifespan Cardiovascular Institute (Rhode Island/Miriam Hospitals), and an Assistant Professor of Medicine at the Warren Alpert Medical School of Brown University. Her clinical expertise includes cardiovascular imaging with a focus on echocardiography and cardiovascular magnetic resonance. She is the director of the cardiac MRI program at the Providence VA Medical Center. Dr. Imran’s research interests include non-invasive imaging, biomarkers in cardiomyopathies, and cardiovascular disease prevention. She is currently the principal investigator of a study supported by the National Institute of General Medical Sciences Cardiopulmonary Vascular Biology COBRE grant to examine the association of advanced imaging and blood biomarkers with quality of life and functional status in patients with heart failure with preserved ejection fraction. Dr. Imran has co-authored numerous articles in peer-reviewed journals and several book chapters. She is an ad-hoc reviewer for Journal of the American College of Cardiology and JACC Heart Failure.
Dr. Imran earned her medical degree at University of Miami Miller School of Medicine in Florida and a master of public health degree from the Harvard School of Public Health in Boston, MA. She completed a preventive cardiology fellowship at Brigham and Women’s Hospital and VA Boston, Harvard Medical School, and a cardiovascular medicine fellowship at Boston Medical Center/Boston University School of Medicine.