The overarching focus of the Jamieson lab is understanding how the immune system can respond to multiple inflammatory insults at the same time. We are specifically interested in how the lung orchestrates the local, organismal, and systemic responses. We have also been at the forefront of understanding host tolerance, which is the concept that in order to survive an infection the host must not only clear the pathogen but withstand changes to homeostasis triggered by both the pathogen and the host response. The laboratory has two main interrelated areas of focus: 1) Understanding host disease tolerance and the innate immune response to complex respiratory infections, cancer, and injury (with a specific focus on the role that the lung microbiome plays) and 2) Understanding how the immune system responds to two competing inflammatory insults or “immune triage”. In order to study these topics, we are taking a unique multidisciplinary approach which involves collaborations with pulmonologists, surgeons, bioengineers, and neuroscientists. My lab has developed innovative new models to study the molecular details of viral/bacterial pulmonary coinfections, tissue resilience during pulmonary infection and injury, and innate immune prioritization of lung infections over cutaneous injury. We are specifically interested in understanding the interplay between the immune system, the neural system, and the vasculature.
Amanda Jamieson @amandamjamieson is the Director of and a trainer in the Pathobiology Graduate Program Pathobiology Graduate Program @BrownUPathoGP
She is also a Director of the NIH-PREP program
She is also a trainer in the Molecular Cell Biochemistry (MCB), the Therapeutic Sciences, Computational Biology, and the Biomedical Engineering (BME) graduate programs. Interested students should apply to one of these programs:
Molecular Biology, Cell Biology and Biochemistry (MCB) Graduate Program
Interested post-doctoral applicants please apply directly.