Projects in the Mani lab
We are pursuing the following areas:
Examine the molecular mechanism by which the EMT equips metastatic competence to cancer cells
Understand how the EMT process equips cancer cells with stem cell properties and promotes plasticity
Develop methods and markers for early detection of cancer cells with EMT/CSC properties within the primary tumor and in circulating tumor cells
Characterize the interplay between tumor cells and immune cells in regulating tumor progression
Using single-cell transcriptomics, genomics, and epigenomic approaches, characterize the heterogeneity in EMT and identify novel therapeutic to treat metastasis and chemoresistance
Assembled and maintained by Nick Kuburich, Ph.D.