Recent publications

2024
  • den Hollander, P., Maddela, J. J., & Mani, S. A. (2024). Spatial and Temporal Relationship between Epithelial–Mesenchymal Transition (EMT) and Stem Cells in Cancer. Clinical chemistry, 70(1), 190-205
2023
  • Kuburich, N. A., den Hollander, P., Castaneda, M., Pietilä, M., Tang, X., Batra, H., … & Mani, S. A. (2023). Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas. Cell reports, 42(12).
  • Kuburich, N. A., Sabapathy, T., Demestichas, B. R., Maddela, J. J., den Hollander, P., & Mani, S. A. (2023, August). Proactive and reactive roles of TGF-β in EMT-induced plasticity. In Seminars in cancer biology. 
  • Fathi, M., Martinez-Paniagua, M., Rezvan, A., Montalvo, M. J., Mohanty, V., Chen, K., … & Varadarajan, N. (2023). Identifying signatures of EV secretion in metastatic breast cancer through functional single-cell profiling. Iscience, 26(4)
  • Lin, K., Zeineddine, M., Chowdhury, S., Hornstein, N., Mani, S., Kopetz, S., & Shen, J. P. (2023). Identification of colorectal cancer stem cells from single cell RNA sequencing. Cancer Research, 83, 2454-2454.
  • Addeo, A., Miranda, E., den Hollander, P., Friedlaender, A., Sintim, H., Wu, J., Mani, S.A. and Subbiah, V., 2023. RET aberrant cancers and RET inhibitor therapies: Current state-of-the-art and future perspectives. Pharmacology & Therapeutics, p.108344.
2022
  • Martínez-Peña, F., Pearson, A.D., Tang, E.L., Kuburich, N.A., Mani, S.A., Schultz, P.G., Bollong, M.J. and Lairson, L.L., 2022. Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers. European Journal of Medicinal Chemistry, 242, p.114638.

  • Castaneda, M., den Hollander, P., Kuburich, N.A., Rosen, J.M. and Mani, S.A., 2022, October. Mechanisms of cancer metastasis. Seminars in cancer biology.

  • Aouad, P., Zhang, Y., De Martino, F., Stibolt, C., Ali, S., Ambrosini, G., Mani, S.A., Maggs, K., Quinn, H.M., Sflomos, G. and Brisken, C., 2022. Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence. Nature communications, 13(1), p.4975.

  • Deshmukh, A.P., den Hollander, P., Kuburich, N.A., Vasaikar, S., Joseph, R. and Mani, S.A., 2022. Enrichment of Cancer Stem Cells in a Tumorsphere Assay. In Stem Cell Assays: Methods and Protocols (pp. 501-507). New York, NY: Springer US.

 

  • den Hollander, P., Joseph, R., Vasaikar, S., Kuburich, N.A., Deshmukh, A.P. and Mani, S.A., 2022. Limiting Dilution Tumor Initiation Assay: An In Vivo Approach for the Study of Cancer Stem Cells. In Stem Cell Assays: Methods and Protocols (pp. 547-554). New York, NY: Springer US.

 

  • Kuburich, N.A., den Hollander, P., Deshmukh, A.P., Vasaikar, S., Joseph, R., Wicha, M.S. and Mani, S.A., 2022. In Vitro Quantification of Cancer Stem Cells Using a Mammosphere Formation Assay. In Stem Cell Assays: Methods and Protocols (pp. 509-513). New York, NY: Springer US.

  • Kudaravalli, S., den Hollander, P. and Mani, S.A., 2022. Role of p38 MAP kinase in cancer stem cells and metastasis. Oncogene, pp.1-9.

 

  • Castaneda, M., den Hollander, P. and Mani, S.A., 2022. Forkhead box transcription factors: double-edged swords in cancer. Cancer Research.

 

  • Visal, T.H., den Hollander, P., Cristofanilli, M. and Mani, S.A., 2022. Circulating tumour cells in the-omics era: how far are we from achieving the ‘singularity’?. British journal of cancer, pp.1-12.
2021
  • Kuburich, N.A., den Hollander, P., Pietz, J.T. and Mani, S.A., 2021, December. Vimentin and cytokeratin: good alone, bad together. In Seminars in cancer biology. Academic Press.

 

  • Joseph, R., Soundararajan, R., Vasaikar, S., Yang, F., Allton, K.L., Tian, L., den Hollander, P., Isgandarova, S., Haemmerle, M., Mino, B. and Zhou, T., 2021. CD8+ T cells inhibit metastasis and CXCL4 regulates its function. British journal of cancer, 125(2), pp.176-189.

 

  • Vasaikar, S.V., Deshmukh, A.P., den Hollander, P., Addanki, S., Kuburich, N.A., Kudaravalli, S., Joseph, R., Chang, J.T., Soundararajan, R. and Mani, S.A., 2021. EMTome: A resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures. British journal of cancer, 124(1), pp.259-269.

 

  • Deshmukh, A.P., Vasaikar, S.V., Tomczak, K., Tripathi, S., Den Hollander, P., Arslan, E., Chakraborty, P., Soundararajan, R., Jolly, M.K., Rai, K. and Levine, H., 2021. Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing. Proceedings of the National Academy of Sciences, 118(19), p.e2102050118.

  • Balcik-Ercin, P., Cayrefourcq, L., Soundararajan, R., Mani, S.A. and Alix-Panabières, C., 2021. Epithelial-to-Mesenchymal Plasticity in Circulating Tumor Cell Lines Sequentially Derived from a Patient with Colorectal Cancer. Cancers, 13(21), p.5408.

 

  • Fathi, M., Joseph, R., Adolacion, J.R.T., Martinez-Paniagua, M., An, X., Gabrusiewicz, K., Mani, S.A. and Varadarajan, N., 2021. Single-cell cloning of breast cancer cells secreting specific subsets of extracellular vesicles. Cancers, 13(17), p.4397.

 

    • Bushnell, G.G., Deshmukh, A.P., den Hollander, P., Luo, M., Soundararajan, R., Jia, D., Levine, H., Mani, S.A. and Wicha, M.S., 2021. Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge. NPJ Breast Cancer, 7(1), pp.1-12.
    2020
    • Arnold, J.M., Gu, F., Ambati, C.R., Rasaily, U., Ramirez-Pena, E., Joseph, R., Manikkam, M., San Martin, R., Charles, C., Pan, Y. and Chatterjee, S.S., 2020. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene, 39(15), pp.3089-3101.

     

    • Yang, J., Antin, P., Berx, G., Blanpain, C., Brabletz, T., Bronner, M., Campbell, K., Cano, A., Casanova, J., Christofori, G. and Dedhar, S., 2020. Guidelines and definitions for research on epithelial–mesenchymal transition. Nature reviews Molecular cell biology, 21(6), pp.341-352.

     

    • Ramirez-Peña, E., Arnold, J., Shivakumar, V., Joseph, R., Vidhya Vijay, G., den Hollander, P., Bhangre, N., Allegakoen, P., Prasad, R., Conley, Z. and Matés, J.M., 2019. The epithelial to mesenchymal transition promotes glutamine independence by suppressing GLS2 expression. Cancers, 11(10), p.1610.
      2019
      • Jia, W., Deshmukh, A., Mani, S.A., Jolly, M.K. and Levine, H., 2019. A possible role for epigenetic feedback regulation in the dynamics of the epithelial–mesenchymal transition (EMT). Physical biology, 16(6), p.066004.

       

      • Vijay, G.V., Zhao, N., Den Hollander, P., Toneff, M.J., Joseph, R., Pietila, M., Taube, J.H., Sarkar, T.R., Ramirez-Pena, E., Werden, S.J. and Shariati, M., 2019. GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer. Breast Cancer Research, 21(1), pp.1-14.

       

      • Ramirez-Peña, E., Arnold, J., Shivakumar, V., Joseph, R., Vidhya Vijay, G., den Hollander, P., Bhangre, N., Allegakoen, P., Prasad, R., Conley, Z. and Matés, J.M., 2019. The epithelial to mesenchymal transition promotes glutamine independence by suppressing GLS2 expression. Cancers, 11(10), p.1610.

       

      • Jia, W., Deshmukh, A., Mani, S.A., Jolly, M.K. and Levine, H., 2019. A possible role for epigenetic feedback regulation in the dynamics of the epithelial–mesenchymal transition (EMT). Physical biology, 16(6), p.066004.

       

      • Soundararajan, R., Fradette, J.J., Konen, J.M., Moulder, S., Zhang, X., Gibbons, D.L., Varadarajan, N., Wistuba, I.I., Tripathy, D., Bernatchez, C. and Byers, L.A., 2019. Targeting the interplay between epithelial-to-mesenchymal-transition and the immune system for effective immunotherapy. Cancers, 11(5), p.714.

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      Assembled and maintained by Nick Kuburich, Ph.D.