The Darling Lab conducts basic science and translational investigations involving mesenchymal stem cells. Areas of emphasis include single-cell elastic and viscoelastic properties (mechanophenotyping) and cellular biomarker discovery. Ongoing studies are looking at the issue of cellular heterogeneity and its effect on stem cell differentiation and regenerative engineering. Additional work related to these topics and others are pursued through collaborations at Brown University, Rhode Island Hospital, and other research institutions.

Research projects summary

Major research tracks in the Darling Lab include:

Stem cell mechanical properties Fluorescent hyper-compliant microparticles Adipogenesis Fluorescent intracellular target sorted and antigen retrieval process
Single-cell mechanophenotyping Hyper-compliant cell mimics Cellular heterogeneity Biomarker discovery and enrichment