The Darling Lab conducts basic science and translational investigations involving materials, mechanics, and mesenchymal stem cells. Areas of emphasis include single-cell elastic and viscoelastic properties (mechanophenotyping), cellular biomarker discovery, and applications of hyper-compliant microparticles. Ongoing studies are looking at the issue of cellular heterogeneity and its effect on stem cell differentiation and regenerative engineering. Additional work related to these topics and others are pursued through collaborations at Brown University, Rhode Island Hospital, and other research institutions.

Research projects summary

Major research tracks in the Darling Lab include:

Stem cell mechanical properties Fluorescent hyper-compliant microparticles Adipogenesis Fluorescent intracellular target sorted and antigen retrieval process
Single-cell mechanophenotyping Hyper-compliant microparticles Cellular heterogeneity Biomarker discovery and enrichment