Darling Lab

Biomedical Engineering, Biotechnology, and Therapeutics

Category: Publications (Page 1 of 4)

Stem cell immunomodulation

The Darling Lab article “Temporal responsiveness of adipose-derived stem/stromal cell immuneplasticity” was accepted for publication in Experimental Cell Research. This study described the response of stem cells to inflammatory stimuli over time. It also revealed that macrophages can be modulated to an anti-inflammatory state by stem cells regardless of the latter’s prior exposure to inflammatory molecules. Congratulations to lead author Addie Parsons!

Measuring antibody removal from labeled cells

 The Darling Lab article “Quantification of Antibody Persistence for Cell Surface Protein Labeling” was accepted for publication in Cellular and Molecular Bioengineering. This study demonstrated a broadly accessible protocol for evaluating the persistence of antibody binding on cell surfaces, which is important for any cellular therapies that rely on positive-marker enrichment of cell subpopulations. Congratulations to lead author Megan Dempsey!

Encapsulation of cells for diagnostics and therapeutics

 The Darling Lab article “Single‐Cell Microgels for Diagnostics and Therapeutics” was accepted for publication in Advanced Functional Materials. This progress report gathers and synthesizes the newest findings related to single-cell encapsulation as a resource for both new and experienced scientists in the field. It introduces the most common materials, devices/techniques, and ultimate applications associated with single-cell encapsulation.

Quantification of mechanical forces within cell-dense biological structures

 The Darling Lab article “Force sensors for measuring microenvironmental forces during mesenchymal condensation” was accepted for publication in Biomaterials. This study demonstrated an exciting, new way to directly measure the microscale forces that cells exert, and have exerted on them, in developing tissue structures. Congratulations to lead author Robert Gutierrez!

Cell-like polymer microparticles for calibration of flow-based devices

 The Darling Lab article “Effect of elastic modulus on inertial displacement of cell-like particles in microchannels” was accepted for publication in Biomicrofluidics. This study demonstrated how polymer cell mimics of defined size and stiffness could be used to map out the flow paths of cells, which vary in these characteristics, within a microfluidic device. Congratulations to lead author Ryan Dubay!

Rapid, high-throughput separation of cells by protein level

 The Darling Lab article “Mass-Added Density Modulation for Sorting Cells Based on Differential Surface Protein Levels” was accepted for publication in Cytometry Part A. This study demonstrated a new methodology for non-binary separation of cells by surface protein expression that makes feasible the enrichment of billions of cells within minutes. Congratulations to lead author Sylvia Sarnik!

Proteomic signatures of nerve cells from human Alzheimer’s disease brains

 The Darling Lab article “Generating cell type-specific protein signatures from non-symptomatic and diseased tissues” was accepted for publication in Annals of Biomedical Engineering. This study demonstrated how diverse cell subpopulations can be enriched for using highly specific, intracellular targets and subsequently analyzed for their differences across thousands of proteins.

Shape-preserved cell replicas

 Our collaborative study between the Kaehr Lab (Sandia) and Darling Lab (Brown) “Cell Replicas: Shape‐Preserved Transformation of Biological Cells into Synthetic Hydrogel Microparticles” was accepted for publication in Advanced Biosystems and selected for the cover. Congratulations to all the contributing authors!

Quantifying practical characteristics of cell sorting technologies

 The Darling Lab article “Considerations for high-yield, high-throughput cell enrichment: fluorescence versus magnetic sorting” was accepted for publication in Scientific Reports. Congratulations to lead author Bryan Sutermaster!

Hyper-compliant particles rapidly penetrate malignant cell spheroids

 The Darling Lab article “Integration of hyper-compliant microparticles into a 3D melanoma tumor model” was accepted for publication in Journal of Biomechanics. Congratulations to lead author Manisha Shah!

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