Olivia Beane and co-authors published a study entitled “Disparate Response to Methotrexate in Stem Versus Non-Stem Cells” in Stem Cell Reviews and Reports that investigated the influence of stemness on the susceptibility of cells to the chemotherapeutic drug, methotrexate. Findings showed that adipose-derived stem cells were unaffected by the drug unless they were undergoing differentiation, at which point they would be impaired in a similar manner to fibroblasts and osteoblasts.
