Author: Eric Darling

A Darling Lab collaboration resulted in the publication of “Deficient Mechanical Activation of Anabolic Transcripts and Post-Traumatic Cartilage Degeneration in Matrilin-1 Knockout Mice” in PLOS ONE. Congratulations to the Chen Lab on a great study!

A collaborative project between the Darling and Hoffman-Kim Laboratories found that by replicating cell-like surface topography and stiffness using a moldable hydrogel embryonic stem cells could grow as if they were on living, mouse embryonic fibroblasts. The paper entitled “A… Continue Reading →

Olivia Beane and co-authors published a study entitled “Disparate Response to Methotrexate in Stem Versus Non-Stem Cells” in Stem Cell Reviews and Reports that investigated the influence of stemness on the susceptibility of cells to the chemotherapeutic drug, methotrexate. Findings showed that adipose-derived stem… Continue Reading →

Eric Darling coauthored a new review with Dr. Dino Di Carlo (UCLA) on the ways researchers are evaluating cellular mechanophenotypes. This paper, titled “High-throughput assessment of cellular mechanical properties,” was published in Annual Reviews of Biomedical Engineering.

Nick Labriola and Eric Darling report the lab’s findings on differentiating mesenchymal stem cells in the publication “Temporal heterogeneity in single-cell gene expression and mechanical properties during adipogenic differentiation,” published in the Journal of Biomechanics.

Olivia Beane and colleagues investigate the effects of aging on stem cells in their recently published paper, “Impact of aging on the regenerative properties of bone marrow-, muscle-, and adipose-derived mesenchymal stem/stromal cells” in PLOS ONE.

Congratulations to Hetal Marble on the publication of her article entitled “Gene expression-based enrichment of live cells from adipose tissue produces subpopulations with improved osteogenic potential” in Stem Cell Research & Therapy. The study demonstrates that stem/stromal cells can be sorted… Continue Reading →